Small but clear pro-hemostatic effects of blood donation-induced stress on donor’s hemostasis (original) (raw)

Background: Donating blood induces stress responses in donors, e.g. increased anxiety and blood pressure. Whereas acute stress in a non-donation setting is associated with pro-hemostatic effects, such effects in blood donors have not been investigated, despite potential importance for the quality of blood products. Therefore, this study examines whether donation-induced stress has an effect on hemostatic parameters in whole-blood donors. Study design and methods: In 372 healthy whole-blood donors, three sets of stress-related parameters were assessed at needle insertion: 1) psychological stress (i.e. donation-stress and arousal on a visual analogue scale); 2) hormonal stress, (i.e. cortisol in saliva); and 3) physiological stress (i.e. blood pressure, pulse rate, and pulse rate variability). Hemostatic parameters (PT, aPTT, fibrinogen, factor VII, factor VIII, and von Willebrand factor (vWF)) were assessed using a 5-ml citrated blood sample taken from the diversion pouch directly af...

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