698.16961 Original Article Anaesthesia Section Analgesic Effect of Intrathecal Nalbuphine in Comparison with Fentanyl as an Adjuvant with Hyperbaric Bupivacaine (0.5%) during Spinal Anaesthesia in Lower Abdominal Surgery: A Double-blinded Randomised Clinical Study (original) (raw)

Abstract

Introduction: Local anaesthetics are sometimes added with intrathecal adjuvants. Nalbuphine is a synthetic agonistantagonist of opioid μ receptor. Fentanyl is a highly potent lipophilic synthetic opioid with rapid onset of action and it acts like morphine. It can be used during spinal anaesthesia for the purpose of decreasing the postoperative pain. Aim: To compare the safety and efficacy of preservative free intrathecal nalbuphine and fentanyl as additives to intrathecal hyperbaric bupivacaine (0.5%) for spinal anaesthesia. Materials and Methods: A randomised double-blinded clinical study was undertaken at Calcutta National Medical College and Hospital, India during March 2020 to August 2021 in which a total of 100 patients, belonging to American Society of Anaesthesiology (ASA) I and II and undergoing elective lower abdominal surgery, were randomised into two equal group of 50 each. Group N received intrathecally 0.5 mg of nalbuphine with 3 mL (15 mg) of 0.5% hyperbaric bupivacain...

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  25. Professor, Department of Pharmacology, Calcutta National Medical College and Hospital, Kolkata, West Bengal, India. PlAgiAriSm CheCKing methoDS: [Jain H et al.] • Plagiarism X-checker: Jun 27, 2022 • Manual Googling: Sep 09, 2022 • iThenticate Software: Sep 20, 2022 (23%) etymology: Author Origin nAme, ADDreSS, e-mAil iD oF the CorreSPonDing Author: Dr. Arunava Biswas, Maharaja Jitendra Narayan Medical College and Hospital, Coochbehar, Coochbehar, West Bengal-736101, India.
  26. E-mail: drabiswas@gmail.com Date of Submission: Jun 26, 2022 Date of Peer Review: Jul 27, 2022 Date of Acceptance: Sep 12, 2022 Date of Publishing: oct 01, 2022