Adiponectin and visfatin levels in extremely low birth weight infants; they are also at risk for insulin resistance (original) (raw)
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OBJECTIVE: The aims of this study were to examine the relationships between adiponectin, insulin, visfatin and weight at birth in healthy term infants. DESIGN AND METHODS: Anthropometric parameters including weight, length were measured and plasma lipid profiles, insulin, visfatin and adiponectin concentrations in cord blood samples from 50 LGA and 50 AGA singleton infants born at term after uncomplicated pregnancies were assayed. RESULTS: Mean visfatin and adiponectin levels were significantly higher in the LGA group than AGA group (11.8 ± 8 vs. 6.3 ± 5.5 ng/ml, p<0.001; 28.4 ± 3.9 vs. 25.7 ± 3.6 μg/ml, p=0.001; respectively). Insulin, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol levels did not differ significantly between LGA and AGA infants. Cord plasma adiponectin, visfatin and insulin levels correlated significantly and positively with birthweight (p=0.01, p<0.001, p<0.001; respectively) and with birthlength (p=0.01, p<0.001, p=0.01; respecti...
Circulating levels of adiponectin in preterm infants
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2007
Objective: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. Design: Prospective study. Setting: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group).
Archives of Medical Research, 2006
Background. Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth. Methods. We performed a transverse comparative study in SGA and appropriate-forgestational-age (AGA) infants. The study was conducted at the Hospital of Gynecology and Obstetrics in Leon, Mexico. Weight, length, and percent of body fat were evaluated during the first 48 h of birth. Glucose, insulin, leptin, adiponectin, and IGF-I levels in cord blood were measured. Results. We studied 100 infants (50 SGA and 50 AGA). A history of diabetes in a second-degree relative was higher in SGA infants than in AGA infants (48.0 vs. 30.0%, respectively; p 5 0.03). Glucose, adiponectin, insulin and IGF-I levels were similar between the groups. Leptin levels and percentage of body fat were lower in SGA than AGA (15.3 vs. 23.4 ng/mL; p 5 0.003, 11.1 vs. 12.7%; p !0.001, respectively). Logistic regression analysis showed that length, percentage of body fat, and leptin levels were positively associated with birthweight. However, leptin levels were not independent of percentage of body fat. Conclusions. Low body fat and leptin levels, but no evidence of increased metabolic risk at birth, were found in SGA infants.
Preterm and Term Newborns Serum Adiponectin and Leptin Concentrations Maced
2020
Introduction: Serum adipocytokines concentration, their mutual relationship and correlations with anthropometric data could be indicators of fetal and neonatal growth maturity level in term and preterm infants. Objectives: Study was designed to assess the correlation of the anthropometric parameters with leptin and adiponectin levels in healthy preterm and term newborns. Design and Methods: A cohort of 110 neonates of both sexes, born pre term (PT) (n=36) or at term (AT) (n=74), additionally classified as AT-AGA (n=36), AT-SGA (n=18), AT-LGA (n=20) and PT-AGA (n=24), PT-SGA (n=12), according to the Lubchenco curves Mother Body Mass Index-MBMI, Birth Weight-BW, Birth Length-BL, Body Weight/Body Length ratio-BW/BL, Body Mass Index-BMI, Ponderal Index-PI, was recorded after birth. Results: Sex has no influence on mean serum leptin and adiponectin level. However, differences between AT and PT groups were highly (p<0.01) significant (2.20 ± 1.02; 30.77 ± 22.64 and 1.24 ± 0.35; 9.44 ± 4.82 ng/mL, respectively). Significant difference was found in adiponectin levels between AT-AGA and AT-LGA compared to AT-SGA subgroup (32.8 ± 25.41 and 43.40 ± 16.98 vs 12.67 ± 2.45 ng/ mL, respectively, (p<0.01; p<0.01). There was a significant difference between leptin levels (1.93 ± 0.70; 1.71 ± 0.53 vs 3.12 ± 1.27 ng/mL) in AT-AGA and AT-SGA compared to AT-LGA newborns, respectively, (p<0.01; p<0.01). No significant differences were found in leptin and adiponectin levels neather between PT subgroups (1.30 ± 0.38 ng/mL) nor between PT group and AT-SGA (1.71 ± 0.53 ng/mL) subgroup. Leptin and adiponectin levels were positively correlated with all anthropometric parameters: BW, BL, BW/BL, BMI, and PI (p<0.05). Conclusion: These results indicate that the stage of body growth maturity is positively correlated to adipocytokines involved in fetal growth regulation.
Macedonian Journal of Medical Sciences, 2012
Introduction: Serum adipocytokines concentration, their mutual relationship and correlations with anthropometric data could be indicators of fetal and neonatal growth maturity level in term and preterm infants. Objectives: Study was designed to assess the correlation of the anthropometric parameters with leptin and adiponectin levels in healthy preterm and term newborns. Design and Methods: A cohort of 110 neonates of both sexes, born pre term (PT) (n=36) or at term (AT) (n=74), additionally classified as AT-AGA (n=36), AT-SGA (n=18), AT-LGA (n=20) and PT-AGA (n=24), PT-SGA (n=12), according to the Lubchenco curves Mother Body Mass Index-MBMI, Birth Weight-BW, Birth Length-BL, Body Weight/Body Length ratio-BW/BL, Body Mass Index-BMI, Ponderal Index-PI, was recorded after birth. Results: Sex has no influence on mean serum leptin and adiponectin level. However, differences between AT and PT groups were highly (p<0.01) significant (2.20±1.02; 30.77±22.64 and 1.24±0.35; 9.44±4.82 ng/mL, respectively). Significant difference was found in adiponectin levels between AT-AGA and AT-LGA compared to AT-SGA subgroup (32.8±25.41 and 43.40±16.98 vs 12.67±2.45 ng/mL, respectively, (p<0.01; p<0.01). There was a significant difference between leptin levels (1.93±0.70; 1.71±0.53 vs 3.12±1.27 ng/mL) in AT-AGA and AT-SGA compared to AT-LGA newborns, respectively, (p<0.01; p<0.01). No significant differences were found in leptin and adiponectin levels neather between PT subgroups (1.30±0.38 ng/mL) nor between PT group and AT-SGA (1.71±0.53 ng/mL) subgroup. Leptin and adiponectin levels were positively correlated with all anthropometric parameters: BW, BL, BW/BL, BMI, and PI (p<0.05). Conclusion: These results indicate that the stage of body growth maturity is positively correlated to adipocytokines involved in fetal growth regulation.
European Journal of Endocrinology, 2007
A Klamer and K Skogstrand contributed equally to this work Abstract Objective: Adiponectin levels measured in neonatal dried blood spot samples (DBSS) might be affected by both prematurity and being born small for gestational age (SGA). The aim of the study was to measure adiponectin levels in routinely collected neonatal DBSS taken on day 5 (range 3-12) postnatal from infants. Design: A retrospective case-control study. Subjects and methods: One hundred and twenty-two infants: 62 very premature (34 SGA) and 60 mature infants (27 SGA). Adiponectin concentrations were determined in stored neonatal DBSS using a sandwich immunoassay based on flow metric Luminex xMap technology. Results: Adiponectin was measurable in all samples, and repeated measurements correlated significantly (rZ0.94). Adiponectin concentrations were negatively associated with both SGA (BZK0.283, PZ0.04) and prematurity (BZK2.194, P!0.001), independently of each other. In the premature but not the mature group, adiponectin levels increased with increasing postnatal age at blood sampling (BZ0.175, P!0.001). Conclusions: Reliable quantification of adiponectin in stored DBSS is feasible and may be used to study large populations of routinely collected samples. Low levels of adiponectin in neonatal DBSS are associated with SGA as well as prematurity. Blood adiponectin levels increase with postnatal age in premature infants, suggesting a rapid yet unexplained metabolic adaptation to premature extrauterine life.
Clinical Endocrinology, 2009
Background and objective Being born as large for gestational age (LGA) has an increased risk of developing insulin resistance. Hypoadiponectinaemia is associated with insulin resistance. The aim of this study was to evaluate adiponectin levels and insulin resistance in association with body composition in LGA born non-obese children at prepubertal ages. Patients and methods Thirty-five (17 female and 18 male) LGA born non-obese children (mean age 4·8 ± 0·3 years) were evaluated with respect to glucose, insulin, IGFBP-1, leptin, adiponectin levels and body composition by DEXA. Their data were compared to that of non-obese 49 (20 female, 29 male) appropriate for gestational age (AGA) children (mean age 3·8 ± 0·1 year). Results LGA children, who had similar body mass index standard deviation scores (BMI SDS) as AGA children, had significantly higher insulin ( P = 0·043) and statistically borderline significant homeostasis model assessment-insulin resistance (HOMA-IR) levels ( P = 0·054) than those of AGA children. Adiponectin levels were significantly lower in LGA than AGA children ( P = 0·004) even after controlling for age, sex and BMI ( P = 0·016). IGFBP-1, leptin levels and body composition did not show a difference. When the LGA group was divided into subgroups according to birth weight, the analysis revealed that after controlling for BMI, being an LGA and having a higher birth weight in the upper half were associated with lower adiponectin levels (estimated marginal means of logarithmic adiponectin levels 2·6 ± 0·2 vs. 2·1 ± 0·2 μ g/ml, P = 0·042). Conclusion LGA children have higher insulin and lower adiponectin levels than AGA children in spite of similar BMI. Adiponectin is a better indicator of insulin resistance in LGA children at prepubertal ages and is affected by birth weight.
Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
Journal of Perinatal Medicine, 2000
Objective: Several mechanisms of disease have been implicated in the pathophysiology of small-for-gestational-age (SGA) including an anti-angiogenic state, and an exaggerated intravascular pro-inflammatory response. Adiponectin plays a role in a wide range of biological activities including those that have been implicated in the pathophysiology SGA. Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate. Study design: This cross-sectional study included women with: 1) a normal pregnancy (ns234); and 2) an SGA neonate (ns78). SGA was defined as a birth weight below the 10 th percentile for gestational age at birth. The study population was further stratified by first trimester body mass index (BMI) (normal weight -25 kg/m 2 vs. overweight/obese G25 kg/m 2 ). Maternal serum adiponectin multimers wtotal, high-molecular-weight (HMW), medium-molecular-weight (MMW) and low-molecularweight (LMW)x concentrations were determined by ELISA. Non-parametric statistics were used for analyses. Results: 1) The median maternal serum concentrations of total, HMW and MMW adiponectin were significantly lower in patients with an SGA neonate than in those with normal pregnancies; 2) patients with an SGA neonate had a significantly lower median HMW/total adiponectin ratio and higher median MMW/total adiponectin and LMW/total adiponectin ratios than those with a normal pregnancy; 3) among patients with an SGA neonate, neither maternal serum concentrations of adiponectin multimers, nor their relative distribution differ between normal weight and overweight/obese patients. Conclusion: 1) Pregnancies complicated by an SGA neonate are characterized by a alterations in the maternal serum adiponectin multimers concentrations and their relative abundance; 2) the findings reported herein suggest that maternal adipose tissue may play a role, in the pathogenesis of SGA.
Cord blood adiponectin in large-for-gestational age newborns
American Journal of Obstetrics and Gynecology, 2005
Adiponectin Leptin LGA Macrosomia Fetal growth Objective: The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth (''overweight''). Study design: Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-forgestational age (LGA; 4297 G 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 G 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels. Results: Mean adiponectin level was significantly lower in LGA newborns (29.4 G 13.8 vs 35.0 G 9.9 mg/mL, P ! .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns. Conclusion: The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults.