The release rate and simulation of heparin-filled hollow fiber patch (original) (raw)

The paper develops a new drug delivery system using a heparin-filled hollow fiber patch, designed for localized heparin delivery. Preliminary in-vitro results indicate that the patch can release Fragmin continuously for over two weeks, maintaining higher local concentrations than those achieved via constant infusion for up to two days. This suggests that the hollow fiber patch is an effective method for local drug delivery, with implications for improving the safety and efficacy of treatments requiring heparin.