Structural investigation of some novel synthesized Schiff base Transition metal complexes derived from drug together with Antimicrobial study (original) (raw)
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Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of Schiff’s Base.pdf
Structural modification of organic molecule has considerable biological relevance. Further, coordination of a biomolecules to the metal ions significantly alters the effectiveness of the biomolecules. In view of the antimicrobial activity a series of nickel, copper and zinc complexes of tridentate Schiff base derived from the condensation reaction of S-benzyldithiocarbazate with 2- hydroxyacetophenone have been synthesized and found to be potential antimicrobial agents. An attempt is also made to correlate the biological activities with geometry of the complexes. The complexes have been characterized by molar conductance, magnetic susceptibility, IR and electronic spectroscopic techniques.
The aim of the present work is to synthesize some Schiff base complexes of metal ion and to evaluate their antimicrobial activities. Novel Schiff base ligand derived from 2-hydroxybenzophenone with S-benzyldithiocarbazate and its metal complexes with Ni (II), Cu (II), Zn (II) and Cd (II) have been synthesized and evaluated for their antibacterial activities by disc diffusion method and antifungal activities by PDA medium. The complexes have been characterized by conductance, magnetic, IR and electronic spectroscopic techniques.
Application of Metal Complexes of Schiff Bases as an Antimicrobial Drug: A Review of Recent Works
International Journal of Current Pharmaceutical Research
Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scop...
Journal of Advanced Scientific Research
We have synthesized a new class of Schiff-base Ligands with m-pthaladehyde and 3-amino benzoic acid. This adduct act as bi-dentate (N8#x38;O) ligand in the formation of mononuclear transition metal complexes of nickel (II), zinc (II), copper (II), cobalt (II), and cadmium (II). Ligand and complexes are characterized and their formation was confirmed by spectroscopic techniques i.e. 1HNMR, FTIR, and UV-Vis spectroscopy. We have synthesized Ligand-metal coordination sphere [M2+(L)2] (where M = Cu(II), Co(II), Cd(II),Ni(II)and Zn(II)) and L=3,3'-((1E,1'E)-(1,3 phenylenebis (methanylylidene)) bis (azanylylidene)) dibenzoic acid and (E)-N-((1H-indol-3-yl) methylene)-4H-1,2,4-triazole-4- amine. Both Ligand and their metal complexes showed magnificent antimicrobial property against Pseudomonas aeruginosa (MTCC 741) which causes nosocomial infections and E. coli (MTCC 1610) which causes intestinal infection.
A new Schiff base ligand (N-pyridin-2-yl-4-[(pyridin-2-yl)methyl amino]benzene sulfonamide) (L) was prepared by the reaction between sulfapyridine and pyridine-2-aldehyde. The ligand is bidentate by coordinating through pyridinyl nitrogen and azomethine nitrogen atom with Co(II), Ni(II), Cu(II), Zn(II) and Mn(II) chlorides. The complexes were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, IR, H 1 NMR and electronic spectral data. These complexes were screened in vitro antibacterial activity against the test microorganisms Staphylococcus aureus, Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger. The results of these studies revealed that all complexes exhibit significant to moderate antimicrobial activity. aldehydes like indole-2-aldehyde and pyrrole-2-aldehyde are coupled with sulfa drugs the resulting compound sulfadrugimine can act as an effective antibacterial agent 10 . In the present investigation an attempt has been made to synthesize Schiff base by coupling pyridine-2-aldehyde and sulfapyridine and also its complexes with various first row transition metal chlorides.
Structural Characterization and Bio-Activity Study of Schiff Base Metal Complexes
INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH IN TECHNOLOGY, 2018
The structural modification of organic molecules has considerable biological relevance and coordination of these compounds to metal ions significantly alters their biological activity. With this views , some S chiff base ligands are synthesized by the condensation of unsub/sub. aminothiazole with salicyl/napthyl aldehyde and their metal complexes with trasition metals. Cu(II),Ni(II),Zn(II) and Co(II) are prepared by adopting earlier procedure1. The complexes are characterized by elemental analysis, spectral study as well as by magnetic moment measurement. The structural elucidation of the molecules is based on electronic, IR, NMR as well as Magnetic S usceptibility measurement. The data are indicative of the fact that metal is bonded to ligand through phenolic oxygen and imino nitrogen atom. The anti-microbial assay of the prepared samples are carried out by adopting modern protocol and found to be good antibacterial and antifungal agents2.
Current Journal of Applied Science and Technology
Benzoylpyridine and nitro benzoic acid hydrazides were used to examine novel Schiff base Co(II), Mn(II), Fe(II), and Cu(II) complexes. Elemental analysis, molar conductance, magnetic measurements and other methods that like FT-IR, UV–Vis and 1H NMR studies have been used to deduce the nature of bonding and structure of these complexes. These studies revealed that the Co(II), Mn(II), Fe(II) and Cu(II) coordinated by four donor atoms in all the complexes. Free radical scavenging activity was determined according to the elimination of radicals from 2,2-diphenyl-1-picrylhydrazyl (DPPH). These compounds were compared to known antibiotics ciprofloxacin and fluconazole in their ability to inhibit the growth of pathogenic bacteria Bacillus subtilis (as gramme positive bacteria), Pseudomonas sp. (as gramme negative bacteria), and fungus Rhizoctonia sp., Alternaria sp., and Fusarium oxysporum. As an antibacterial and antioxidant agent, the complexes are more effective than the ligand. The cop...
Some selected solid the lowering shift of the stretching frequency of the ν(CH=N) azomethine band in the ligand after complexation, indicated the coordination through the phenolic oxygen atom (after deprotonation) and azomethine nitrogen atom respectively of the Schiff base ligand HL. The lower values of molar conductance indicate the non-electrolytic nature of these complexes. The ESR spectrum of the HL copper complex has octahedral geometry. The molecular structures of the investigated compounds were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and the it's complexes. The antimicrobial screening of the synthesized compounds HL and its complexes 1-3 were investigated. The Schiff base ligand HL showed weaker to significant activity against one or more bacterial and fungal strains. In most of the cases higher activities were exhibited upon coordination with metal ions(II). In addition, calculations in silico, the Pharmacokinetic parameters have promising features for applying the ligand as drug.
Tetradentate Schiff Base Complexes of Transition Metals for Antimicrobial Activity
Arabian Journal for Science and Engineering, 2020
Synthesis of tetradentate Schiff base (SB) complexes of Cu(II), Co(II), and Ni(II) was done by the condensation of 2-aminophenol/o-phenylenediamine and terepthaldehyde in an alcohol medium, and the complexes were characterized by utilizing FTIR, LCMS, and UV-visible analysis. From the analytical, electronic, and magnetic data, octahedral geometry has been proposed for all the complexes. The antibacterial studies were studied for the SB ligands and their complexes against Bacillus subtilis 2393, Proteus vulgaris 426, Klebsiella sp., S. aureus 3160, and Escherichia coli 4604. Their antifungal activities were studied against Aspergilus flavus, Aspergillus niger, Cryptococcus neoformans, and Penicillium chrysogenum. The outcomes revealed that the transition metal complexes revealed good antibacterial and antifungal activities.