Prognostic Impact of Deletion 17p Clone Size on Outcome in Chronic Lymphocytic Leukemia Patients (A Real Life Routine Practice Perspective in Brazil) (original) (raw)

Blood, 2018

Abstract

Objectives: Chronic lymphocytic leukemia (CLL) presents a heterogeneous clinical course. Treatment mainly aims to control clinical manifestations and improving survival. Some biological markers have significant prognostic value. Cytogenetic studies in CLL have central role to refine the follow-up of disease evolution, to guide treatment options and monitoring response. Due to low mitotic index in conventional cytogenetic studies, fluorescence in situ hybridization (FISH) became an indispensable tool. The main objective of this study was analyze the presence of del(17p13) using FISH and the percentage of positive cells that have impact on survival, along with clinical characteristics from CLL patients. Methods: Seventy-one CLL patients were studied from 2010 to 2017. Median age was 57 years old and male patients were 56,4%. FISH analysis was performed using peripheral blood samples from patients and TP53 spectrum srange/CEP 17 spectrum green probe (Vysis). Statistical analysis was pe...

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