Role of Antioxidants on Reducing Reactive oxygen species In Diabetic Patients (original) (raw)
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A review on the role of antioxidants in the management of diabetes and its complications
Biomedecine & …, 2005
Diabetes is a prevalent systemic disease affecting a significant proportion of the population worldwide. The effects of diabetes are devastating and well documented. There is increasing evidence that in certain pathologic states, especially chronic diseases, the increased production and/or ineffective scavenging of reactive oxygen species (ROS) may play a critical role. High reactivity of ROS determines chemical changes in virtually all cellular components, leading to lipid peroxidation. Production of ROS and disturbed capacity of antioxidant defense in diabetic subjects have been reported. It has been suggested that enhanced production of free radicals and oxidative stress is central event to the development of diabetic complications. This suggestion has been supported by demonstration of increased levels of indicators of oxidative stress in diabetic individuals suffering from complications. Therefore, it seems reasonable that antioxidants can play an important role in the improvement of diabetes. There are many reports on effects of antioxidants in the management of diabetes. In this paper, after complete bibliography and criticizing all relevant articles, the relationships between diabetes and oxidative stress and use of antioxidants in the management of diabetes and its complications have been well reviewed. This review well indicates that oxidative stress is involved in the pathogenesis of diabetes and its complications. Use of antioxidants reduces oxidative stress and alleviates diabetic complications.
Screening of Anti- oxidant Property of a Siddha Herbal Formulation, Krambu karpam
Conference Proceeding, 2013
Siddha is one of the ancient Traditional systems of medicine in India which was gifted by the great 18 Siddhars. Siddha Medicines play a very important role in treating chronic and even challenging diseases like Cancer, HIV, and Hepatitis etc. The use of Siddha Medicine for both therapeutic and prophylactic purposes is being documented through clinical and pre-clinical screening. In that way, the concept of Anti-oxidant which has components of “Kaya Karpam” in Siddha plays a tremendous role for the well being of Mankind. The special therapy of Kaaya Karpam deals with the Prevention of NARAI (grey hair), THIRAI (shrinkening of Skin), PINI (illness), MOOPU (aging) and SAAKADU (death). The test drug, ‘Kirambu Karpam’ has its reference in the age old Siddha text, ‘THERAIYAR MAHA KARISAL’. Kirambu Karpam’ was prepared as per Standard Operative Procedures, and subjected to In-vitro cell line Anti-oxidant screening using Nitrous oxide radical scavenging, Total anti-oxidant activity and Hydroxyl radical scavenging assays. The superior anti-oxidant properties of the test drug were proved through the screening results which are being discussed in detail. Key words: Siddha Medicine, Anti-oxidants, Nitrous oxide radicals, In-vitro cell line studies.
Anti-Diabetic Herbs in Siddha system of Medicine
academician and clinician about the promising siddha herbs have anti-diabetic activity. This review has offered the recent advancement of herbs in siddha medicine has an anti-diabetic activity, with the vision to support the further research and also give the permanent resolution for the society.
Evaluation of in-vitro Anti Diabetic Activity of a Siddha Herbo- Mineral Drug
The nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Therefore, there is a necessity to explore their uses and to ascertain their therapeutic properties. In that way, the Traditional Siddha Medicine plays a vital role in preventing the progress of the disease. Saint Yugi (one of the Founders of Traditional Indian Siddha system of Medicine) describes 21 types of Mega noigal, which includes Madhu megam (Madhu – Sweet, Megam – Disease) [1, 2]. Diabetes mellitus is compared with Madhu megam in Siddha literature. Diabetes mellitus is a complex and a diverse group of disorders that disturbs the metabolism of carbohydrate, fat and protein. The number of diabetes mellitus cases has been increasing worldwide in recent years. Insulin is a key player in the control of glucose homeostasis. Lack of insulin affects carbohydrate, fat and protein metabolism. Management of diabetes without side effects is still a great challenge to the medical community [3]. The aim of the present study is to investigate the in-vitro Anti-Diabetic activity of the selected Herbo- Mineral drug, having its reference in age old Siddha classic text “Sarabhendhirar Vaithiya Ratnavali”. Thus, validating the traditional claim of the Herbo-mineral drug exhibits a significant inhibitory effect on In-vitro glucose diffusion and the result is being discussed.
Anti-oxidative Activity of Nepalese Traditional Anti-diabetic Medicines
Nepal Journal of Science and Technology, 2014
Chronic overproduction of free radicals in human body has a role in numerous disease states including diabetes. Proper use of antioxidants may help in the prevention and/or treatment of diabetes. For the management of diabetes, a combination of herbal drugs is being practiced traditionally in Nepal. These herbal medicines might have a good correlation to anti-oxidative properties. Anti-oxidative property was evaluated with the methanolic extracts of nineteen common traditional anti-diabetic medicines by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. Among the evaluated herbal medicines, Phyllanthus emblica, Punica granatum, Syzygium cumini, Terminalia bellirica and Terminalia chebula showed potent radical scavenging activity. The activities of P. emblica, T. bellirica and T. chebula were more potent than that of ascorbic acid. Some of the reported popular hypoglycemic herbal drugs did not show strong activity. Therefore strong anti-oxidative herbal drugs in combination with hypoglycemic drugs might have better results in the management of diabetes.
The Role of Antioxidants on Oxidative Stress in Diabetes Mellitus
Journal of Pharmacy Technology, 2010
Many patients use dietary supplements, including vitamins, minerals, and herbal products, on a daily basis to improve their health. Pharmacists can educate patients about the proper use of dietary supplements and the role of these supplements on their health.
Journal of Pharmacy Research, 2014
Herbal medicines are popular remedies for diseases used by a vast majority of the world's population. Herbal formulations, which have attained widespread acceptability as therapeutic agents in India, include nootropics, antidiabetics, hepatoprotective agents, and lipidlowering agents. The pharmacological effects of many plants have been studied in various laboratories, whereas there are many limitations regarding the safety and efficacy of these preparations [1]. Diabetes Mellitus is a chronic endocrine disorder caused by an absolute or relative lack of insulin and/or reduced insulin activity that results in hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism. Diabetes has emerged as a major healthcare problem in India [2]. Type 2 Diabetes is one of the major health problems all over the world. The management of diabetes is considered a global problem. The modern drugs including insulin and oral hypoglycemic agents control the blood sugar level as long as they are regularly administered, and also produce a number of undesirable side effects. The treatment of diabetes has been attempted with different indigenous plants and polyherbal formulations. Pre-clinical toxicity studies are
The Role of Herbal Medicine in Oxidative Stress: Prevention of Diabetes
2023
The pathophysiology of diabetes mellitus is heavily influenced by oxidative stress, which is defined by an imbalance between reactive oxygen species (ROS) and antioxidant defenses. Innovative methods for managing and preventing diabetes are required given that it is a growing worldwide health concern. Herbal medicine, which has a long history of use in traditional therapeutic methods, has drawn interest for its ability to reduce the incidence of diabetes and combat oxidative stress. The processes underpinning the damage caused by ROS to cellular components and signaling pathways are revealed in this chapter as it delves into the complex interactions between oxidative stress and diabetes. The essential function of antioxidant substances in reducing oxidative stress is investigated, emphasizing the change from traditional herbal knowledge to contemporary scientific validation. The botanical substances that provide a source of inorganic antioxidants are at the center of this discussion. Fenugreek (Trigonella foenum-graecum) and Bitter Melon (Momordica charantia), two important medicinal herbs, are investigated for their strong antioxidant capacities and their capacity to modify glucose homeostasis and insulin sensitivity.Scientific studies, including in vitro experiments and clinical trials, shed light on how well herbal treatments for diabetes prevention actually work. Additionally, the beneficial effects of herbal combinations are clarified, as well as the importance of combining these interventions with lifestyle changes. The fusion of herbal medicine and conventional therapies appears as a promising route for diabetes prevention as the movement toward holistic health gains popularity. In conclusion, this chapter underscores the multifaceted potential of herbal medicine in addressing oxidative stress as a crucial factor in diabetes prevention. By embracing the wisdom of ancient traditions and leveraging contemporary scientific insights, herbal interventions offer a holistic and integrative strategy to safeguard against the escalating global burden of diabetes.