Castleman’s Disease—A Rare Diagnosis in the Retroperitoneum (original) (raw)
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A rare case of retroperitoneal castleman disease
IP innovative publication pvt. ltd, 2019
Castleman disease is a rare hyperplastic disorder that can affect any group of lymph nodes. Clinically and radiologically, it can mimic a malignancy and can only be diagnosed by histopathological examination. Castleman disease should be considered as one of the differential diagnosis for a patient presenting with a retroperitoneal mass. Complete surgical excision is usually curative; a preoperative diagnosis by biopsy can avoid extensive surgery for this condition. In this case report, we present a 40 year old female with a retroperitoneal mass, which was clinically suspected to be a malignancy. Complete surgical excision was done and histopathological examination of the mass revealed a unicentric Hyaline vascular type of Castleman disease.
A Case of Retroperitoneal Castleman's Disease and an Update on the Latest Evidence
Case reports in surgery, 2014
Castleman's disease is a benign lymphoproliferative condition with three distinct histological subtypes. Clinically it presents in either a unicentric or multicentric manner and can affect various anatomic regions, the mediastinum being the most frequent location. We herein present a rare case of unifocal retroperitoneal mass proved to be hyaline vascular Castleman's disease. We perform a review of the current literature pertaining to such lesions, focusing on the management of the various clinical and histological variants of the disease. Surgical excision is the treatment of choice for unifocal Castleman's disease.
Surgical management of abdominal and retroperitoneal Castleman's disease
World journal of surgical oncology, 2005
Abdominal and retroperitoneal Castleman's disease could present either as a localized disease or as a systemic disease. Castleman's disease is a lymphoid hyperplasia related to human Herpes virus type 8, which could have an aggressive behavior, similar to that of malignant lymphoid neoplasm mainly with the systemic type, or a benign one in its localized form. The authors report two cases of localized Castleman's disease in the retroperitoneal space and review the current and recent progress in the knowledge of this atypical disease. The two patients were young healthy women presenting with a hyper vascular peri-renal mass suggestive of malignant tumor. Both have been resected in-toto. One of them had an extensive resection with nephrectomy, while the second had a kidney preserving surgery. Pathological examination revealed localized Castleman's disease and surgical margins were free of disease. Postoperative course was uneventful, and after more than 5-years of follo...
Unicentric retroperitoneal Castleman disease: Report of 3 cases
Cumhuriyet Medical Journal, 2015
Castleman Disease is a rare lymphoproliferative disorder mainly occuring in the mediastinum. Abdominal forms are less frequent and manifests rarely as an isolated retroperitoneal mass. The diagnosis is based on postoperative pathological findings. Herein, we report three cases of unicentric retroperitoneal Castleman Disease from our center. Three women were detected to have a retroperitoneal mass in the medical examinations. The masses were surgically removed and histopathological examination revealed a hyaline-vascular type of Castleman disease. Although retroperitoneal Castleman Disease is rare, it should be considered in the differential diagnosis of retroperitoneal masses.
A Case Report on Isolated Retroperitoneal Castleman's Disease
Castleman disease (CD) is an uncommon lymph proliferative disorder and is especially rare in the retro peritoneum or per renal area. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. After removal of the lesion, local CD has a good prognosis. It is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue related to the chronic human herpes virus 8
UNICENTRIC CASTLEMAN DISEASE PRESENTING AS A LARGE RETROPERITONEAL MASS-A CASE REPORT
Castleman disease (CD) described by castleman as a large,benign,asymptomatic mass involving mediastinal lymph nodes.The causes of CD are mostly unknown.As patients with CD can have markedly different presentation and clinical courses,with some lesions requiring innovative approaches to therapy, the major unifying feature is the histologic appearance. It may be unicentric or multicentric, hyaline-vascular variant or plasma cell variant. Unicentric variant mostly present as a isolated lymph node mass ,often mediastinal or cervical. We present a case of unicentriccastleman disease (hyaline vascular variant) presenting as a large retroperitoneal mass.
Life Science Journal
Castleman’s disease (CD) is a rare benign disorder characterized by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. CD comprises at least two distinct diseases (unicentric (localized) and multicentric) with very different prognoses. Surgery remains the main treatment for resectable unicentric CD. The two principal histologic subtypes of CD are hyaline-vascular, plasma cell variants and a mixed variant. We report two cases of unicentric Castleman’s disease (UCD) treated at our institute that mimic retroperitoneal neoplasm and cured by surgical excision. We review the literature on the management of this rare entity and concentrate more on UCD.
A case of incidentally detected Castleman's disease with retroperitoneal paravertebral localization
International Journal of Urology, 2000
Castleman's disease, or angiofollicular lymph node hyperplasia, is a fairly rare benign tumor of lymphoid origin. The expected localization is mediastinum and rarely retroperitoneum. An asymptomatic case is reported with multimodality imaging and postoperative findings. The lesion was detected incidentally on routine chest radiogram. Surgical exploration revealed a retroperitoneal mass and the mass was resected successfully through a thoracoabdominal flank incision. Castleman's disease should be included in the list of differential diagnosis of retroperitoneal masses which are mostly malignant tumors.
Unicentric Castleman’s Disease: Laparoscopic Approach of a Para-Duodenal Retroperitoneal Mass
American Journal of Case Reports
Objective: Rare disease Background: Castleman's disease is a benign, lymphoproliferative disorder that is extremely uncommon. Multiple classifications have been described; however, the exact etiology remains unknown. Preoperative diagnosis is not common, as imaging cannot distinguish the disease from other processes, and biopsy is insufficient to provide the architecture of the mass, which is necessary for diagnosis. Unicentric retroperitoneal disease has been described, and management includes complete resection of the mass, which is usually curative. Case Report: A 34-year-old previously healthy woman presented with hematuria. Evaluation revelated a retroperitoneal mass that was abutting the duodenum and head of the pancreas. Biopsy failed to provide a diagnosis, so laparoscopic resection was performed. Postoperative diagnosis was consistent with unicentric Castleman's disease. Conclusions: Castleman's disease is an uncommon process, and one that is difficult to diagnose. Unicentric Castleman's disease should always be a differential diagnosis of solitary retroperitoneal masses that are well-demarcated, as treatment can be curative with surgical resection.