Formulation and Evaluation of Ibuprofen Gel using a Natural Polymer (original) (raw)
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Development and evaluation of ibuprofen transdermal gel formulations
Tropical Journal of Pharmaceutical Research, 2010
Purpose: To develop an ibuprofen transdermal gel with a capability for both topical and systemic drug delivery. Methods: Ibuprofen gel formulations, incorporating various permeation enhancers, were prepared using chitosan as a gelling agent. The formulations were examined for their in vitro characteristics including viscosity, pH and drug release as well as in vivo pharmacological activities. Carrageenan-induced rat paw oedema model was used for the evaluation of their analgesic and anti-inflammatory activities. A commercial ibuprofen gel product (Ibutop ®) was used as a reference. Results: The formulations containing 5 % of either menthol or glycerol as permeation enhancers gave drug release patterns comparable to that of the reference product. Propanol increased the apparent viscosity of the test gels to the same extent as that of the reference. Drug release from the formulations fitted best to the Higuchi model. A significant in vivo analgesic effect was produced by the test formulations containing 5 % menthol and 20 % propylene glycol and the effect was superior to that obtained with the reference product. However, no significant anti-inflammatory activity was exerted by any of the test gel formulations (p > 0.05). Conclusion: Ibuprofen gel preparations containing 5 % menthol and 20 % propylene glycol, respectively, exhibited pronounced analgesic activity and could be further developed for topical and systemic delivery of ibuprofen.
Formulation and Evaluation of Transdermal Topical Gel of Ibuprofen
Journal of Drug Delivery and Therapeutics, 2020
The present research work is based on the formulation and evaluation of topical gel of Ibuprofen where Carbopol 940 is used as the polymer. Gels were prepared by dispersing the polymers in a mixture of water and glycerol with methyl paraben as the preservative and the varying amount of ibuprofen, being kept under magnetic stirring until the homogeneous dispersion was formed. The dispersion was then neutralized and made viscous by the addition of triethanolamine. The Carbopol gels of Ibuprofen were found to be homogenous with good drug loading. The pH of all the gel formulations was found within the neutral pH range which is compatible with skin. And the viscosity of the formulations was found to be feasible for topical drug delivery. The drug content of the three formulations was found in the range of 87.56% to 90.45% which shows efficient drug loading. Results of In vitro drug release study showed that F5 formulation has better diffusion of drug through egg membrane and hence furt...
Formulation and Evaluation of Organo-Transdermal Gel of Drug Ibuprofen
International Journal of Pharmaceutical Sciences and Medicine
The current research project is centered on the development and assessment of an Ibuprofen topical gel made with Guar gum as the polymer and Carbopol 940 as a penetration enhancer. [ Gels were made by dispersing the polymers in a solution of guar gum and isopropyl myristate, along with Carbopol 940, glycerol as aqueous agents, and potassium sorbate as preservative, and different concentrations of ibuprofen, all while maintaining magnetic stirring. Triethanolamine was then added to the dispersion to neutralize it and make it viscous. Ibuprofen - Guar gum gels were discovered to be homogeneous and to have adequate drug loading. All of the gel compositions' pH values fell within the range of neutral pH, which is suitable for skin. And it was discovered that the compositions' viscosity was suitable for topical use the drug content of the nine formulations was found in the range of 80% to 90% which shows efficient drug loading. The compatibility study showed that the major peaks ...
Formulation and Evaluation of Sustained Release Matrix Type Transdermal Film of Ibuprofen
The present study was undertaken to investigate the effect of different polymers on the release profile of Ibuprofen from the matrix type transdermal film. Transdermal films of Ibuprofen using Eudragit L 100, Kollidon SR and their combination were separately prepared by solvent casting method. Drug release was evaluated for eight hours and the release mechanisms were explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The release rate, extent and mechanisms were found to be independent of the polymer concentration in case of Eudragit L 100. But those were found to be directed by polymer concentration for formulations containing Kollidon SR and the combination of Eudragit L 100 and Kollidon SR. Higher polymer content in the matrix decreased the rate and extent of the drug release because of increased matrix strength and gel formation around the matrix particularly for these formulations containing Kollidon SR. On the other hand, a burst drug release was obtained from films containing Eudragit L 100, while the combination of Eudragit L 100 and Kollidon SR gave an intermediate release profile of Ibuprofen from the transdermal films. Proper adjustment of these polymers in the transdermal film of ibuprofen can offer desirable release characteristics.
MODIFIED RELEASE HYDROGELS OF IBUPROFEN FOR ORAL DRUG DELIVERY: AN OVERVIEW
The Present study for hydrogels are specifically on the pH sensitive hydrogels for oral drug delivery system. Hydrogels are able to improve oral delivery of several therapeutic agents established by various in-vitro methodologies. Hydrogels are basically cross-linked polymers with hydrophilic nature & consist of acidic, basic, or neutral monomers which are able to swallow large amounts of water. Due to hydrophilic nature of polymer chains, hydrogels will engross water to swell in the presence of abundant water. The swelling properties of hydrogels are due to elasticity of the network, presence of hydrophilic functional groups (such as-COOH,-OH,-SO3H,-CONH2) in the polymer chains. The physiochemical properties, swelling studies and gelling capacity significantly govern the selection of hydrogel component. The development of hydrogels has received substantial consideration over past few years. This interest has been flickered by the advantages these advanced delivery system possess, which include modified, sustained and prolonged action, reduced dose, less side-effects, better drug utilization, better patient compliance, site specific drug targeting, protection of mucosa from irritation, prevention from general first pass metabolism .Non-steroidal anti-inflammatory drugs are mostly prescribed for the patients suffering from rheumatoid arthritis, osteoarthritis, soft tissue injuries, traumatic arthritis and other inflammatory disorders etc. Ibuprofen is non-steroidal anti-inflammatory drug (NSAID) which is anti-inflammatory, antipyretic and analgesic properties. It is chemically "2-(4-iso-butylphenyl)-propanoic acid" and is poorly soluble in water. It is mostly administered through oral route and is rapidly absorbed to reach its maximal plasma concentration within 2 hrs. It has a short biological half-life period of 2 hours, which means that numerous doses are required to maintain the therapeutic efficacy level over extended period of time. Frequent administrations of drug cause GIT side effects such as gastric ulceration, perforation and bleeding. pH sensitive hydrogel of ibuprofen attain a more modified & sustain release of the drug for long periods of time interval. Hence we can minimize the required dose and toxicity of the drug.
Evaluation of the Release Profiles of Ibuprofen Formulated.pdf
Purpose: To investigate the sustained release characteristics of ibuprofen lipospheres made from Capra hircus (GF) and carnauba wax (CW) in comparison with conventional granules as standard. Methods: Ibuprofen (90 g) and the lipid (30 g) were prepared by melt dispersion technique. Conventional granules of ibuprofen were prepared with starch mucilage, 20% w/v. Resulting lipospheres were characterized with respect to sizes, flow property, bulk and tap densities, encapsulated in hard gelatin capsules and evaluated for drug release profiles. Results: Dissolution profile for lipospheres were a maximum drug release of 97% in 1 hr (conventional granules), 23% in 4 hr (GF), 60% in 2 hr (CW) and 40% in admixtures of fats (GC). Admixing the fats enhanced flow properties of the lipospheres. Inclusion of a surfactant enhanced the release profiles from the lipospheres. Conclusion: Formulation of ibuprofen into lipospheres modified the release profile, which has implications in the formulation of...
2007
The present research aimed at formulation and evaluation of the mucoadhesive microspheres forsalbutamol sulphate using thiolated pectin as a polymer for controlled release dosage form by optimization technique using software-based response surface methodology. In current investigation preparation of salbutamol based mucoadhesive microspheres was optimized using two important process variables i.e. drug: polymer ratio and volume of glutaraldehyde. The desired responses are particle size and drug entrapment efficiency. Optimization was done by fitting experimental data to the software programme (Design Expert® 9 trial version). The microspheres were evaluated for physicochemical parameters as shape, size, Fourier Transform-Infrared (FT-IR), XRD and% entrapment efficiency. SEM studies showed that the microspheres were in a spherical form. The Entrapment efficiency of salbutamol microspheres was found to be 61 ± 1.34%. Further it was found that optimum % Entrapment efficiency and Particle size can be achieved by using best possible combination of Drug: Polymer ratio and volume of cross-linking agent. The in vitro drug release estimated in 0.1N HCl (pH 1.2) after 8 hours was found to be 81.65 ± 1.301%. The release studies showed the drug release was increased with thiolated pectin formulation as compared to the formulation prepared by pectin.
Formulation and Evaluation of Ibuprofen Topical Gel: A Novel Approach for Penetration Enhancement
2011
This study aimed to increase the therapeutic effectiveness of ibuprofen by increasing its transdermal permeation, via solid dispersion incorporated in gel. 2- hydroxy propyl beta cyclodextrins (2-HPβ-CD) and β-cyclodextrin (β-CD) were used as carriers and carbopol 941 was the gelling agent. Eight solid dispersion formulations of ibuprofen were prepared using different drug: polymer ratios viz. 1:0.5, 1:1, 1:2, and 1:3 for 2-HPβ-CD and β cyclodextrin using the co-evaporation method, and were evaluated for partition coefficient, dissolution studies, and Fourier Transform Infra Red (FTIR) spectrophotometer. The optimized solid dispersion of ibuprofen was incorporated into gel and was compared with penetration enhancers. The formulations were analyzed to determine their pH, spreadability, viscosity, and in vitro drug release. The absence of extraneous interactions among ingredients was confirmed by FTIR, and differential scanning calorimetry (DSC)
This study aimed to increase the therapeutic effectiveness of ibuprofen by increasing its transdermal permeation, via solid dispersion incorporated in gel. 2-hydroxy propyl beta cyclodextrins (2-HPβ-CD) and β-cyclodextrin (β-CD) were used as carriers and carbopol 941 was the gelling agent. Eight solid dispersion formulations of ibuprofen were prepared using different drug: polymer ratios viz. 1:0.5, 1:1, 1:2, and 1:3 for 2-HPβ-CD and β cyclodextrin using the co-evaporation method, and were evaluated for partition coefficient, dissolution studies, and Fourier Transform Infra Red (FTIR) spectrophotometer. The optimized solid dispersion of ibuprofen was incorporated into gel and was compared with penetration enhancers. The formulations were analyzed to determine their pH, spreadability, viscosity, and in vitro drug release. The absence of extraneous interactions among ingredients was confirmed by FTIR, and differential scanning calorimetry (DSC)
International Journal of Pharmacy and Pharmaceutical Sciences, 2016
Objective: An attempt was made to develop sustained release matrix tablets of ibuprofen using HPMC (K4M, K15M & K100M) and eudragit (RS 100 & RL 100) as release retardant polymers. Methods: The ibuprofen matrix tablets were prepared by direct compression method using lactose as a diluent. Nineteen formulations of different polymer percentages were formulated, (F1-F19 with 7.5%, 10%, 15%, 20%, 25%, 30% w/w). Results: The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 7.2 pH phosphate buffer as a dissolution medium, showed that optimized formulation F8 consisting of eudragit RL with 20% of the polymer was found to sustain the release of ibuprofen over a period of 12 h. The formulation exhibited highest correlation (R) value in case of Hixson-Crowell model and the release kinetic study proved that the formulation showed erosion process, and shown to follow zero order kinetics. Conclusion: It was concluded that eudragit RL can be used for the preparation of sustained release tablet of ibuprofen.