A Comparative Study between Antioxidant Activity of Medical Ozone and Selenium on Experimentally-Induced Diabetes in Male Rats (original) (raw)

2017

Abstract

Introduction: Ozone therapy has been used in recent decades and has been found useful in treatment of diabetes. It improves glycemia, prevents oxidative stress, and normalizes level of organic peroxides. Selenium is an essential dietary trace element that has an antioxidant effect. It functions as an integral part of glutathione peroxidase in addition to its important role in vitamin E metabolism and normal pancreatic functions. Aim of Work: To determine the roles of ozone administration in amelioration of oxidative stress in STZ-induced diabetes so as to establish its potential use in the strategy for treatment of diabetes. Material and Methods: This study was applied on 50 male albino rats that were divided into 5 equal groups: Control group, diabetic group, ozone-treated diabetic group (received three IP injections/week on alternating days of medical ozone at a dose of 1.2mg/kg BW), selenium-treated diabetic group (received oral selenium as sodium selenite at a dose of 1.5mg/kg B...

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