A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis (original) (raw)
A Computational Evaluation of the Mechanism of Penicillin-Binding Protein-Catalyzed Cross-Linking of the Bacterial Cell Wall
Jed Fisher
Journal of the American Chemical Society, 2011
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Catalytic Mechanism of the Streptomyces K15 dd-Transpeptidase/Penicillin-Binding Protein Probed by Site-Directed Mutagenesis and Structural Analysis
Dominique Dehareng
Biochemistry, 2003
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The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length
Eefjan Breukink
FEBS Journal, 2012
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Structural Aspects for Evolution of β-Lactamases from Penicillin-Binding Proteins
George Minasov
Journal of the American Chemical Society, 2003
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Multiple mechanisms of membrane anchoring of Escherichia coli penicillin-binding proteins
David Phoenix
FEMS Microbiology Reviews, 1994
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Crystal Structures of Penicillin-Binding Protein 6 from Escherichia coli
Dusan Hesek
Journal of The American Chemical Society, 2009
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The Crystal Structure of a Penicilloyl-serine Transferase of Intermediate Penicillin Sensitivity. THE DD-TRANSPEPTIDASE OF STREPTOMYCES K15
Eveline Fonze
Journal of Biological Chemistry, 1999
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Crystal Structures of Covalent Complexes of β-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic Specificity
rex pratt
Biochemistry, 2010
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Elucidation of the Structure of the Membrane Anchor of Penicillin-Binding Protein 5 of Escherichia coli
Jed Fisher
Journal of the American Chemical Society, 2010
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Elucidation of the Structure of the Membrane Anchor of Penicillin-Binding Protein 5 of Escherichia coli
Jaroslav Zajícek
Journal of the American Chemical Society, 2010
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Crystal Structure of Penicillin-binding Protein 1a (PBP1a) Reveals a Mutational Hotspot Implicated in β-Lactam Resistance in Streptococcus pneumoniae
Carlos Contreras
Journal of Molecular Biology, 2006
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Atomic Model of a Cell-Wall Cross-Linking Enzyme in Complex with an Intact Bacterial Peptidoglycan
Jean-pierre Simorre
Journal of the American Chemical Society, 2014
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Occurrence of a serine residue in the penicillin-binding site of the exocellular DD-carboxy-peptidase-transpeptidase from Streptomyces R61
Jean-marie Frère
FEBS Letters, 1976
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The Refined Crystallographic Structure of aDD-Peptidase Penicillin-target Enzyme at 1.6 Å Resolution
Alexandre Kuzin
Journal of Molecular Biology, 1995
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Crystal Structures of Complexes between the R61 DD-peptidase and Peptidoglycan-mimetic β-Lactams: A Non-covalent Complex with a “Perfect Penicillin”
Helen Josephine
Journal of Molecular Biology, 2005
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Crystal Structures of Complexes between the R61 DD-peptidase and Peptidoglycan-mimetic ?-Lactams: A Non-covalent Complex with a ?Perfect Penicillin?
Helen Josephine
J Mol Biol, 2005
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Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A
Fumitoshi Ishino
Biochemical and Biophysical Research Communications, 1980
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Solution X-ray scattering study of a full-length class A penicillin-binding protein
Javier Pérez Sanz
Biochemical and Biophysical Research Communications, 2011
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Binding of cephalothin and cefotaxime to D-Ala-D-Ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum .beta.-lactamases
Alexandre Kuzin
Biochemistry, 1995
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The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into -lactam resistance
Charlene Desbonnet
The Journal of Biological Chemistry, 2018
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The Bimodular G57-V577 Polypeptide Chain of the Class B Penicillin-Binding Protein 3 of Escherichia coli Catalyzes Peptide Bond Formation from Thiolesters and Does Not Catalyze Glycan Chain Polymerization from the Lipid II Intermediate
bart devreese
1997
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{"__content__"=>"The structures of penicillin-binding protein 4 (PBP4) and PBP5 from provide structural insights into β-lactam resistance.", "i"=>{"__content__"=>"Enterococci"}}
Alexei Soares
The Journal of biological chemistry, 2018
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Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in -Lactam Resistance
Dusan Hesek
Antimicrobial Agents and Chemotherapy, 2013
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Bacterial cell wall assembly: still an attractive antibacterial target
Christopher Dowson
Trends in Biotechnology, 2011
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The catalytic, glycosyl transferase and acyl transferase modules of the cell wall peptidoglycan-polymerizing penicillin-binding protein 1b of Escherichia coli
Juan Ayala
Molecular Microbiology, 1999
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Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft
Garib Murshudov
Journal of Molecular Biology, 2000
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Cutting and Stitching: The Cross-Linking of Peptidoglycan in the Assembly of the Bacterial Cell Wall
John Buynak
ACS Chemical Biology, 2007
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Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase
Jean-marie Frère
Proceedings of the National Academy of Sciences, 1993
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Crystal structure of a d-aminopeptidase from Ochrobactrum anthropi, a new member of the ‘penicillin-recognizing enzyme’ family
Han Remaut
Structure, 2000
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Reactivity of Penicillin-Binding Proteins with Peptidoglycan-Mimetic β-Lactams: What's Wrong with These Enzymes?
rex pratt
Biochemistry, 2006
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Structure and Dynamics of the Penicillin-Binding Protein 3 from Staphylococcus Epidermidis Native and in Complex with Cefotaxime and Vaborbactam
Fortune Journals
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The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets
Eefjan Breukink
Antibiotics (Basel, Switzerland), 2016
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Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects
Sven van Teeffelen
eLife, 2020
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Membrane topology of penicillin-binding protein 3 of Escherichia coli
B. G Spratt
Molecular Microbiology, 1989
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Binding of β-lactam antibiotics to the exocellular dd-carboxypeptidase–transpeptidase of Streptomyces R39
Ramon RM
Biochemical Journal, 1974
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