Functional polymers. XVI. Synthesis and polymerization of 2(2-hydroxy-5-isopropenylphenyl)-2H-benzotriazole and a new synthesis of 2(2-hydroxy-5-vinylphenyl)2H-benzotriazole (original) (raw)
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Polymer, 1995
The synthesis of several U.V. absorbers of the 2(2-hydroxyphenyl)2H-benzotriazole category is reported. The compounds are of three types: 2(2-hydroxyphenyl)2H-benzotriazoles with one or two substituents located in the benzotriazole moiety of the molecule; 2(2-hydroxyphenyl)2H-benzotriazoles with a substituent in the hydroxy-containing phenyl part of the molecule; and a naphthalene derivative. Syntheses of the 2(2-hydroxyphenyl)2H-benzotriazoles were carried out by the diazotization of a 2-nitroaniline derivative followed by reduction and cyclization, yielding the products in moderate yield. The characterization of the products was carried out by i.r., U.V. and 13C n.m.r. spectroscopy, and included the determination of their molecular weights by elemental analysis and potassium ionization of desorbed species.
SYNTHESIS AND SIGNIFICATION OF BENZOTRIAZOLE ANALOGS IN DIFFERENT PHARMACEUTICAL DRUG
European Journal of Biomedical AND Pharmaceutical sciences, 2016
Benzotriazole being a hetrocylic compound find for their different bioactive structure. Literature indicates that compounds having Benzotriazole nucleus have wide range of therapeutic uses that include antifungal, anticonvulsant, anti-inflammatory, antidiabetic, analgesic, Anti-HIV, ant tubercular, antioxidant, antidepressant, miscellaneous & antitumor activity. The purpose of this review is give an overview of different property of Benzotriazole and some of its application in synthesis of pharmacologically active drug.
https://www.ijrrjournal.com/IJRR\_Vol.8\_Issue.5\_May2021/IJRR-Abstract046.html, 2021
Benzotriazole (BTA) is a nitrogen containing heterocyclic derivative containing three nitrogen atoms at 1 st , 2 nd and 3 rd positions with chemical formula C 6 H 5 N 3. Benzotriazole and its derivatives have great significance in medicinal chemistry and these derivatives were used by several chemists for therapeutic conditions because it possessing a wide spectrum of pharmacological activities including anti bacterial, anti fungal, anti viral, anti inflammatory, anti hyperglycemic, anti hypertensive, anti cancer and analgesic activity. In this review, different synthetic methods for the preparation of benzotriazole, importance of benzotriazole derivatives in biomedical research, highlighting its biological behavior, versatile activities and Structure Activity Relationship (SAR) studies are described. This review will help the researchers to understand the structure activity relationships and improvise the concepts in their research field.
Medicinal Chemistry Research, 2010
Ten novel benzotriazole compounds were synthesized. Their chemical structures were confirmed by 1 H NMR, IR, and elemental analyses, coupled with three selected single-crystal structures (compounds A2, B3, and B5). Their antimycotic and antitumor activities were also investigated. The title compounds showed some antitumor activities, especially in the case of A3 and A4, which showed the most potent activity of propagation inhibition in liver and galactophore cancer cells.
Facile synthesis of novel benzotriazole derivatives and their antibacterial activities
Journal of Chemical Sciences, 2010
A series of benzotriazole derivatives (compounds 1–27) were synthesized, and 24 (compounds 1–5, 9–27) of which were first reported. Their chemical structures were confirmed by means of 1H NMR, IR and elemental analyses, coupled with one selected single crystal structure (compound 1). All the compounds were assayed for antibacterial activities against three Gram positive bacterial strains (Bacillus subtilis, Staphylococcus aureus
Improved synthesis of 5(6)-vinylbenzimidazole: Some polymerization studies
Journal of Polymer Science: Polymer Chemistry Edition, 1978
A general one-step reduction ring closure of o-nitroacetanalides is applied to the synthesis of 5(6)-acetylbenzimidaole and 5(6)-acetyl-2-methylbenzimidazole in good yield. The former is readily converted to the vinyl monomer by reduction and dehydration. Polymerization of this monomer with free-radical initiation under a variety of conditions gives polymers with essentially identical nuclear magnetic resonance (NMR) spectra, implying no basic change in polymer structure.
Synthesis and Characterization of Benzylidene Derivatives of Benzothiazole
IJRASET, 2021
A series of some novel benzothiazole derivatives were synthesized from the 2-(4-aminophenyl) benzothiazol-5-ol, which was synthesized by the Jacobson method using Lawesson's reagent. Benzylidene derivatives (P201-P205) were synthesized by catalyzed condensation and acylation method,named as 2-(4-((4 hydroxybenzylidene)amino) phenyl) benzothiazole-5-ol (P201), 2-(4-((4-methoxybenzylidene) amino)phenyl)benzothiazole-5ol(P202),2-(4-((4-chlorobenzylidene) amino)phenyl)benzothiazole-5-ol(P203), (4-((furan-2-ylmethylene) amino)phenyl)benzothiazole-5-ol(P204), Dimethyl(4(5hydroxy benzothiazol2yl)phenyl)carbonimidodithioate(P205)The structures of the compounds were confirmed by NMR and IR spectral data.
Journal of Polymer Science: Polymer Chemistry Edition, 1981
Successful grafting of 2(2-hydroxy-5-vinylphenyl)2H-benzotriazole onto saturated aliphatic CH groups of polymers has been accomplished. When the grafting reaction was carried out in chlorobenzene at 150–160°C with di-tertiary butylperoxide as the grafting initiator, grafts as high as 20–30% at grafting efficiencies of 50 and 80% have readily been obtained. It was very important to carry out the grafting reaction in tubes sealed under high vacuum since trace amounts of oxygen cause complete inhibition of the grafting reaction by the phenolic monomer. Grafting reactions were carried out on a variety of different polymers including atactic polypropylene, ethylene/vinyl acetate copolymer, poly(methyl methacrylate), poly(butyl acrylate), and polycarbonate.