Utilization of the 1064 nm Wavelength in Photobiomodulation: A Systematic Review and Meta-Analysis (original) (raw)
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Laser Photobiomodulation and Photodynamic Therapy . A Literature Review
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Laser photobiomodulation and photodynamic therapy are new methods for bacteria elimination. The use of low-level laser therapy (LLLT), especially in a combination with a photosensitizer, leads to increase of the ATP production, improvement of the oxyreduction potential of the cells, as well as bacteriolysis. Neither the dye itself, nor the laseer is capable of reducing the number of bacteria as much as their combination. The advantages of these methods, compared to the use of antiseptics or antibiotics, are their local action, absence of systemic side effects and lack of need for maintaining high concentration of the dye.
Dosimetry for photobiomodulation therapy: response to Sommers et al
Annals of translational medicine, 2016
In a recent article by Sommer et al. in Annals of Translational Medicine, the authors make several key comments on our recent article in Scientific Reports entitled "Molecular pathway of near infrared laser phototoxicity involves ATF-4 orchestrated ER stress" (1). Firstly, we would like to thank the authors for their laudatory, constructive comments, specifically appreciating the rigorous effort and potential impact of our work. However, this editorial also raised a few key issues regarding methodology and interpretations in our study. We feel these points could be further clarified for the increasingly enthusiastic audience following nuances of photobiomodulation (PBM) therapy.
Photobiomodulation—Underlying Mechanism and Clinical Applications
Journal of Clinical Medicine, 2020
The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers’ underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. The interest in the application of laser therapy in medicine and dentistry has remarkably increased in the last decade. There are different types of lasers available and their usage is well defined by different parameters, such as: wavelength, energy density, power output, and duration of radiation. Laser irradiation can induce a photobiomodulatory (PBM) effect on cells and tissues, contributing to a directed modulation of cell behaviors, enhancing the processes of tissue repair. Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), can induce cell proliferation and enhance stem cell differentiation. Laser therapy is a non-invasive method that contributes to pain relief and reduces inflammation, parallel to the enha...
Therapeutic Efficacy of Home-Use Photobiomodulation Devices: A Systematic Literature Review
Photomedicine and Laser Surgery, 2018
Objective: Perform systematic literature review on photobiomodulation (PBM) devices used at home for nonesthetic applications. Background: Home-use PBM devices have been marketed for cosmetic and therapeutic purposes. This is the first systematic literature review for nonesthetic applications. Methods: A systematic literature search was conducted for PBM devices self-applied at home at least thrice a week. Two independent reviewers screened the articles and extracted the data. Treatment dosage appropriateness was compared to the World Association for Laser Therapy (WALT) recommendations. The efficacy was evaluated according to the relevant primary end-point for the specific indication. Results: Eleven studies were suitable. Devices were applied for a range of indications, including pain, cognitive dysfunction, wound healing, diabetic macular edema, and postprocedural side effects, and were mostly based on near-infrared, pulsed light-emitting diodes with dosages within WALT recommendations. Regarding efficacy, studies reported mostly positive results. Conclusions: Home-use PBM devices appear to mediate effective, safe treatments in a variety of conditions that require frequent applications. Conclusive evaluation of their efficacy requires additional, randomized controlled studies.
Photodermatology, Photoimmunology & Photomedicine, 2020
Background: Photobiomodulation depends on the use of non-ionizing light energy to trigger photochemical changes, particularly in light-sensitive mitochondrial structures. It triggers proliferation and the metabolic activity of the cells, primarily by utilizing the energy from the near-infrared to the red wavelength of the light. Purpose: This in vitro study has analyzed comparatively the most appropriate energy doses and wavelengths to induce photobiomodulation on keratinocytes and fibroblasts for the accelerated wound healing process. Methods: 1, 3, and 5 J/cm² energy densities of 655-nm and 808-nm diode lasers were used to promote cell proliferation and wound healing process. Scratch assay and MTT analysis were performed on keratinocytes and fibroblasts for wound closure and cell proliferation after the triple light applications, respectively. Results: 655-nm of wavelength was more successful on keratinocytes to induce wound healing and cell proliferation, whereas 808-nm of wavelength was so effective on fibroblasts to heal the wounds totally and it induced cell proliferation almost 3 times compared to the untreated control group. Conclusion: This study revealed that photobiomodulation with 655 and 808 nm of wavelengths was effective to speed up the wound healing process at specific energy densities. In general 808nm of wavelength was more successful. However, the proper wavelength and the energy density may differ according to the cell type. Thus, every light parameter should be chosen properly to obtain better outcomes during photobiomodulation applications.
Oral Oncology, 2019
Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has been increasingly used for the treatment of toxicities related to cancer treatment. One of the challenges for the universal acceptance of PBMT use in cancer patients is whether or not there is a potential for the light to stimulate the growth of residual malignant cells that evaded oncologic treatment, increasing the risk for tumor recurrences and development of a second primary tumor. Current science suggests promising effects of PBMT in the prevention and treatment of breast cancer-related lymphedema and oral mucositis, among other cancer treatment toxicities. Nevertheless, this seems to be the first systematic review to analyze the safety of the use of PBMT for the management of cancer-related toxicities. Scopus, MEDLINE/PubMed, and Embase were searched electronically. A total of 27 articles met the search criteria. Selected studies included the use of PBMT for prevention and treatment of oral mucositis, lymphedema, radiodermatitis, and peripheral neuropathy. Most studies showed that no side effects were observed with the use of PBMT. The results of this systematic review, based on current literature, suggest that the use of PBMT in the prevention and management of cancer treatment toxicities does not lead to the development of tumor safety issues.
Effects of low level laser therapy in cancer cells—a systematic review of the literature
Lasers in Medical Science, 2019
The aim of the present study was to conduct a systematic review regarding the use of photobiomodulation (PBM) therapy in tumoral cells, addressing the different types of lasers and parameters used. An electronic search was performed in PubMed/ MEDLINE, Cochrane Library, and EMBASE databases. The inclusion criteria were being an in vitro study, with tumoral cells, and have at least one group of treatment with low-power laser and a control group (without treatment). Were excluded studies that used only non-carcinogenic cells, in vivo studies, studies that used high-power laser or the association with photosensitizers. The primary outcome evaluated was the cellular viability, and the secondary outcomes were the apoptosis rate and gene and inflammatory mediators' expression. Nineteen studies were identified among the lists of citations of studies that met the exclusion/inclusion criteria. There is a wide divergence regarding the wavelengths and doses used, as well as the type of laser, and each variation leads to different results, with some studies showing an increase in cell proliferation, while other studies showed a decrease. It is possible to suggest that PBM can be used in cancerous lesions in order to decrease the proliferation of these cells depending on the parameters used; however, the lack of standardization of laser irradiation protocols for in vitro investigations does not allow the establishment of ideal parameters for this purpose. Therefore, PBM should be used with caution in cancer patients until more studies are performed.
Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review
Life
COVID-19 is a viral disease characterized as a pandemic by the World Health Organization in March 2020. Since then, researchers from all over the world have been looking for ways to fight this disease. Many cases of complications arise from insufficient immune responses due to low immunity, with intense release of pro-inflammatory cytokines that can damage the structure of organs such as the lung. Thus, the hypothesis arises that photobiomodulation therapy (PBMT) with the use of a low-level laser (LLLT) may be an ally approach to patients with COVID-19 since it is effective for increasing immunity, helping tissue repair, and reducing pro-inflammatory cytokines. This systematic review was performed with the use of PubMed/MEDLINE, Web of Science, Scopus and Google Scholar databases with the following keywords: “low-level laser therapy OR photobiomodulation therapy AND COVID-19”. The inclusion criteria were complete articles published from January 2020 to January 2021 in English. The e...