Proteopedia entry: Beta-prime subunit of bacterial RNA polymerase (original) (raw)

This article presents a tutorial on the beta-prime subunit of bacterial RNA polymerase (RNAP), essential for transcription in all living cells. The study constructs a physical model of the elongation complex of RNAP from Thermus thermophilus and highlights key structures including the trigger helix, which is a potential drug target due to its role in catalysis. The tutorial integrates interactive elements and multimedia to educate students on DNA translocation, nucleotide addition, and the significance of physical positioning within the RNAP complex.