Bitemporal Ganglioglioma: Surgical Management of an Unusual Intracranial and Extracranial Tumor (original) (raw)

Temporal lobe gangliomas in children

Child's Nervous System, 1986

The ganglioglioma, a mixed tumor with neuronal and glial elements, occurs occasionally in children and young adults. Its incidence, clinical presentation, radiological features, and natural history have not been clearly defined. A review of 111 primary brain tumors treated at our institution shows that 9.0% were gangliogliomas. The temporal lobe was the most common site involved. All patients presented with seizures but were neurologically intact. The CT scan showed a partially calcified mass, frequently isodense or nearly so, with minimal enhancement. Complete removal produced dramatic improvement in seizure control. Radiotherapy and/or chemotherapy are reserved for tumors showing malignant changes in the astrocytic component. Patients with chronic epilepsy, or whose seizures escape control despite anticonvulsants, should be examined with this tumor in mind. Following removal of these low-grade temporal lobe tumors, fewer seizures are seen, and the long-term prognosis is very good.

Gangliogliomas: A report of five cases

Indian journal of cancer

Gangliogliomas are rare tumors of the Central Nervous System. Five gangliogliomas were diagnosed out of 1560 brain tumours surgically resected out in a period of 5 years accounting for 0. 32%. We have tried to discuss in detail the pathological features of these tumours and have mentioned the clinical and radiological features associated with them. All the slides, tissue blocks and pathology reports of the surgical specimens of gangliglioma were reviewed and the clinical and radiological data reviewed. The ages of the patients ranged from 7-65 years with 4 males and 1 female. The tumors were located in the lateral ventricle (a rare site), temporal, parietal and the frontal lobes with duration of seizures varying from 1-9 years. The tumors were diagnosed by the presence of a dual population of neoplastic ganglionic and glial components. The glial components consisted of pilocytic astrocytes (l case), fibrillary astrocytes (2 cases), oligodendrocytes (1 case) and anaplastic astrocytes...

A case report of rare location of ganglioglioma

Egyptian Journal of Neurosurgery, 2019

Background Gangliogliomas are rare tumors of the central nervous system. They can occur anywhere in the central nervous system but are most commonly located in the temporal lobe and are mainly found in children. Anaplastic ganglioglioma can result from either de novo or transformation of a pre-existing lesion. Case presentation We report a case of de novo anaplastic ganglioglioma in the parieto occipital region, which is a rare location. A 34-year-old lady presented with features of raised intracranial pressure (ICP) with right side hemiparesis. Contrast-enhanced magnetic resonance imaging (CEMRI) of the brain showed well-defined intense heterogenously enhancing solid cystic mass lesion 5.3 × 5.2 cm in the left parieto occipital region with mass effect and midline shift. Intraoperatively, a cystic mass lesion with reddish brown nodule was seen in the left occipital lobe. Complete tumor excision was done. Microscopic and IHC examination was suggestive of anaplastic ganglioglioma. The...

Intracranial ganglioglioma: A rare case report

Gangliogliomas are considered rare tumors which account for 0.4-0.9% of intracranial neoplasms. The peak of its incidence occurs between 10 and 20 years of age. These tumors are composed of glial and ganglion cells and they are relatively low grade neoplasms associated with good prognosis. We report a rare case of intracranial ganglioglioma in a 10 year old boy who underwent surgery and adjuvant radiotherapy.

Central nervous system gangliogliomas

Journal of Neurosurgery, 1993

The records of 58 patients with gangliogliomas surgically treated between January 1, 1980, and June 30, 1990, were retrospectively reviewed in order to determine long-term survival, event-free survival, and functional outcome resulting after radical resection and to assess the impact of histological grading on outcome. Tumors were located in the cerebral hemisphere in 19 cases, the spinal cord in 30, and the brain stem in nine. Forty-four patients had gross total resection and 14 had radical subtotal resection. Only six patients underwent postoperative irradiation or chemotherapy and, therefore, the outcome was generally related to surgery alone. Of the 58 gangliogliomas, 40 were classified as histological grade I, 16 were grade II, and two were grade III. The median follow-up period was 56 months. There were no operative deaths, and the operative morbidity rate was 5%, 37%, and 33% for cerebral hemisphere, spinal cord, and brain-stem gangliogliomas, respectively. The 5-year actuari...

Gangliogliomas: pathological and clinical correlation

Journal of Neurosurgery, 1981

✓ Fourteen cases of ganglioglioma are analyzed. This tumor can be found anywhere within the central nervous system. The histological appearance is highly variable and does not relate to the biological behavior. The prognosis depends on the location and possible modes of treatment. Overall, the lesion appears to be nonaggressive and consistent with long survival.

Ganglioglioma: a clinical study with long-term follow-up

Surgical Neurology, 1991

Gangliogliomas are uncommon tumors of mixed neoplastic glial and neuronal elements. Because of their low incidence, few large series exist that fully describe the clinical characteristics of patients afflicted with this tumor. We have reviewed the medical records of 20 patients at Duke University Medical Center with histologically proven gangliogliomas. These patients typically presented within the first three decades of life and their most common presenting symptom was seizures. Therapies included surgical resection, either partial or total, radiation therapy, and/or chemotherapy. Long-term follow-up was achieved by chart review and by telephone interview. Patients who underwent gross total resection alone seemed to fare the best when comparing all treatment groups, and we therefore recommend this as the main form of treatment.

MR Findings of Brainstem Ganglioglioma: Case Report and Review of the Literature

2003

Primary intrinsic gangliogliomas of the brainstem are exceedingly unusual. We describe a case of brainstem ganglioglioma in a 14-year-old boy who presented with progressive unsteady gait for one year. Magnetic resonance imaging (MRI) demon- strated a heterogeneous mass arising from dorsal surface of pontomedullary junction. The differential diagnosis of brainstem tumor for a patient with this age includes astrocytoma, intramedullary ependy- moma, medulloblastoma and choroid plexus papil- loma. Ganglioglioma is an uncommon low-grade tumor of the central nervous system (CNS), comprising about 1% to 5% of pediatric brain tumors. The preferential sites of intracranial ganglioglioma are the temporal lobes, followed by frontal and medial parietal lobes. Brainstem gangliogliomas are even rare, with only 34 cases reported in the literature and only 3 cases has been studied with MRI. Herein we present the MRI findings of the fourth case of primary brainstem gan- glioglioma with review of the...