New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Robert Lutjens
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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
Megan Nattini
Bioorganic & Medicinal Chemistry Letters, 2012
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Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists
John Thomas
Bioorganic & Medicinal Chemistry Letters, 2007
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Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models
Youheng Shu
Bioorganic & Medicinal Chemistry Letters, 2020
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Structure–activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5
Alice Rodriguez
Bioorganic & Medicinal Chemistry, 2010
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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N -(4-(2-Methoxyphenoxy)phenyl)- N -(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine
James Monn
Journal of Medicinal Chemistry, 2003
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α-substituted quisqualic acid analogs: New metabotropic glutamate receptor group II selective antagonists
Mario Varasi, Darryl Steensma
Bioorganic & Medicinal Chemistry Letters, 1998
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Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5
Alice Rodriguez
Bioorganic & Medicinal Chemistry Letters, 2011
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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Robert Lutjens
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Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)
Alice Rodriguez
Bioorganic & medicinal chemistry letters, 2016
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N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents
Alice Rodriguez
Bioorganic & medicinal chemistry letters, 2016
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Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
Scott Throner
Bioorganic & Medicinal Chemistry Letters, 2011
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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)- (1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Robert Lutjens
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Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)
奈穂子 金子
Journal of Pharmacology and Experimental Therapeutics, 2007
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Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors
P. Conn
Current Opinion in Pharmacology, 2006
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses
Cyril Goudet
Molecular pharmacology, 2007
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ChemInform Abstract: Synthesis and SAR of a Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 4 (mGluR4)
Corey Hopkins
ChemInform, 2010
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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
Marlene Jacobson
Molecular …, 2003
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Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
Jean-philippe Pin
Journal of medicinal chemistry, 2018
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Combined Strategies for the Discovery of Ionotropic Glutamate Receptor Antagonists
Giovambattista De Sarro
ChemMedChem, 2009
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Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid
Matthew Valli
Bioorganic & Medicinal Chemistry Letters, 1998
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(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist
Belen Yruretagoyena
Bioorganic & Medicinal Chemistry Letters, 1998
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Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
Huiyong Yin
Bioorganic & Medicinal Chemistry Letters, 2008
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Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III
Rainer Kuhn
Bioorganic & Medicinal Chemistry Letters, 2000
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Metabotropic Glutamate Receptor Ligands as Novel Therapeutic Agents
Ashley Brady
The Receptors, 2008
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LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
Paul Ornstein
Neuropharmacology, 1998
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
Thierry Gefflaut
Journal of Medicinal Chemistry, 2016
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Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)
Gerard Marek
Journal of Pharmacology and Experimental Therapeutics, 2007
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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators as Novel Tools for in Vivo Investigation
Thomas M. Keck
ACS Medicinal Chemistry Letters, 2012
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