Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies (original) (raw)
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BioMed Research International
The biological synthesis of nanoparticles, due to their environmental and biomedical properties, has been of particular interest to scientists and physicians. Here, iron nanoparticles (FeNPs) were synthesized using Satureja hortensis essential oil. Then, the chemical, functional, and morphological properties of these nanoparticles were characterized by typical experiments such as Uv-Vis, FTIR, XRD, FE-SEM, PSA, zeta potential, EDX, and EDX mapping. The results indicated Fe nanoparticles’ formation with a cubic morphological structure and a particle size in the range of 9.3-27 nm. The antimicrobial effects of these nanoparticles were further evaluated using disc diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungal concentration (MFC) against two gram-positive bacterial strains (Staphylococcus aureus and Corynebacterium glutamicum), two gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), and one fung...
Green Processing and Synthesis, 2022
Green synthesis of nanoparticles (NPs) is a more sustainable, safe, and environmentally friendly method. This study aimed to investigate the synthesis procedure of iron oxide nanoparticles (IONPs) using the seed extract of Nigella sativa (N. sativa) as a strong reducing agent and to estimate their cytotoxic and antibacterial properties. The obtained IONPs were characterized by field-emission scanning electron microscopy, X-ray diffraction, dynamic light scattering (DLS), zeta potential (ZP), and Fourier-transform infrared spectroscopy analyses. The cytotoxicity of the biosynthesized IONPs was demonstrated by the MTT on a Vero cell line. Furthermore, the antibacterial activity of the fabricated biosynthesis metal oxide NPs was tested on Escherichia coli (E. coli) (ATCC 35218) and Staphylococcus aureus (S. aureus) (ATCC 29213) bacterial strains using the Kirby–Bauer disk diffusion method. This study showed the formation of a well-dispersed, highly stable (ZP ζ = −51.8 mV) IO NPs with ...
Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies
International Journal of Molecular Sciences
Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their effici...
Journal of Drug Delivery Science and Technology, 2019
Nowadays, green synthesized nanoparticles have attracted dramatical attention toward themselves due to their outstanding biocompatibility and eco-friendly nature. Herein, we modified Fe 3 O 4-MgO nanoparticles with Nutmeg essential oil toward development of super magnetic nanoparticles with anti-bacterial and anti-fungal features that can be used as recoverable agent. For this matter, both chemically and green synthesized Fe 3 O 4-MgO nanoparticles were compared with each other where the outcome of FTIR, VSM and EDAX analyses showed that addition of Nutmeg essential oil to the system can improve the overall features of synthesized magnetite nanoparticles in the final composition and significantly enhance the saturation magnetization (M s) from 31.23 emu.g −1 (for chemically synthesized) to 72.29 emu.g −1 (for green synthesized) which shows about 131.47% improvement in the magnetization, while most of green approaches showed adverse effects on the total magnetization. What is more, developed green magnetite nanoparticles showed spherical morphology with very low size of about 10-15 nm. Additionally, the anti-microbial and anti-fungal performance of Nutmeg essential oil and ethanolic/methanolic essence against 8 and 5 diverse bacteria and yeast were evaluated, respectively, where the outcome of these evaluations showed the superior bacteriostatic performance of these Nutmeg derived materials against selected bacteria and yeast even at very low concentrations.
Synthesis of Iron Oxide Nano Particles by the Use of Osmanthus Fragrance Leaf Extract
2018
In this study, a one-pot eco-friendly synthesis technique was successfully employed in synthesizing iron oxide (Fe3O4) nanoparticles from FeCl3.6H2O and FeCl2.4H2O by the use of aqueous extract of sweet scented Osmanthus leaf. The synthesized nanoparticles were characterized by Scanning Electron Microscope (SEM), Fourier Transform Infrared, Thermogravimetry analysis (TGA), UV-vis spectrophotometer, X-ray diffraction (XRD) and Zetasizer nano 3600. The XRD analysis exhibited peaks at; 30.20, 35.57, 43.26, 53.29, 57.26, 62.62, 68.27 and 74.49 corresponding to 220, 331, 400, 422, 551, 440, 533 and 553 respectively which indicates the inverse spinel structure of Fe3O4 shows the crystalinity and high purity of our synthesized Fe3O4 nanoparticles. The iron oxide nanoparticles were in the size range of 20.25nm to 27.04nm.
Wiley, 2018
In the present research, we report a greener, faster, and low‐cost synthesis of gold‐coated iron oxide nanoparticles (Fe 3 O 4 /Au‐NPs) by different ratios (1:1, 2:1, and 3:1 molar ratio) of iron oxide and gold with natural honey (0.5% w/v) under hydrothermal conditions for 20 minutes. Honey was used as the reducing and stabilizing agent, respectively. The nanoparticles were characterized by X‐ray diffraction (XRD), UV‐visible spectroscopy, field emission scanning electron microscope (FESEM), energy‐dispersive X‐ray spectroscopy (EDXS), transmission electron microscopy (TEM), selected area electron diffraction (SAED), vibrating sample magnetometer (VSM), and fourier transformed infrared spectroscopy (FT‐IR). The XRD analysis indicated the presence of Fe 3 O 4 /Au‐NPs, while the TEM images showed the formation of Fe 3 O 4 /Au‐NPs with diameter range between 3.49 nm and 4.11 nm. The VSM study demonstrated that the magnetic properties were decreased in the Fe 3 O 4 /Au‐NPs compared with the Fe 3 O 4 ‐NPs.
Applied Sciences
Capparis zeylanica leaf extract was employed in this work to create iron oxide nanoparticles (α-Fe2O3) using anhydrous ferric chloride. The UV spectrum, XRD, FT-IR, and FE-SEM with EDX methods were used to characterize the fabricated nanoparticles. The iron oxide nanoparticles obtained were spherical in form, with an average crystallite size of 28.17 nm determined by XRD. The agar well diffusion method was used to assess the antimicrobial activity of the α-Fe2O3 nanoparticles created in this study against pathogenic organisms, Gram-negative bacteria (Escherichia coli and Pseudomonas aeroginosa), Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), and fungi (Candida albicans and Aspergillus niger). Among the pathogens tested, S. pyogenes had the highest zones of inhibition (25 ± 1.26 mm), followed by S. aureus (23 ± 0.8 mm), E. coli (23 ± 2.46 mm), P. aeroginosa (22 ± 1.86 mm), C. albicans (19 ± 2.34 mm) and A. niger (17 ± 3.2 mm). The substance was further tes...
Basic Nano Magnetic Particles and Essential Oils: Biological Applications
2021
Essential oils (EOs) are complex mixtures of volatile compounds with different biological properties. Essential oils and their ability to resist the production of biofilms by pathogenic microorganisms have been linked to antimicrobial activity. After adherence of these pathogenic microorganisms to surfaces leads primarily to antibiotic resistance, it is vital to look for compounds or methodologies with this capacity. Essential oils have gained a lot of attention in recent years due to studies of their anti-bacterial, antiviral, anti-fungal, and insecticidal properties. Due to their low toxicity, biocompatibility, biodegradability, capability to precisely target tissue, and initial structures that enable various therapeutics to be attached, MNPs (magnetite nanoparticles) are one kind of nanocarrier that could be used to deliver EOs for antimicrobial therapies effectively.
Iron oxide nanoparticles have been intensively investigated due to their magnetic characteristics, and their potential applications in the area of bioscience and medicine. Iron oxide nanoparticles with their non-toxic and biocompatible effects can be used in biomedical applications ranging from drug delivery to hyperthermia for tumor targeted therapy. Targeted drug delivery is achieved by super Para magnetism by which the required magnetic alignment is achieved at normal temperature. Surface shaping of iron oxide nanoparticles is done accordingly for coating of plant extracts which acts as the required drug for cancer therapy. Certain plant extracts contains poly phenols which performs the role of reduction and precipitations .such methods do not harm the environment and fall under "Green synthesis".
Crystals
Microwave-assisted hydrothermal synthesis is a simple, reproducible, rapid, and effective method, and therefore, has attracted considerable interest among scientists in the field of synthesis not only of iron oxide but also of other metal oxides. This method has been used for the synthesis of iron oxide nanoparticles, hematite (α-Fe2O3), and goethite (α-FeOOH) in strongly alkaline media with iron(III) chloride (FeCl3) as precursor under microwave emission of 850 W. In this work, the effect on the size, shape, and composition of the final product was investigated by changing the conditions, such as shortening the synthesis time, increasing the synthesis temperature, and adding various substances to the synthesis pathway. Samples synthesized at 200 °C for 20 min by increasing the added percentage of polyethylene glycol (PEG), sodium dodecyl sulfate (SDS), rosemary essential oil and lavender essential oil promote goethite-to-hematite transformation, while N-guanylurea sulfate (NGS) and...