Standardization, evaluation and quantification of herbal drugs by various analytical methods (original) (raw)
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The demand for herbal medicine is increasing as herbs are less toxic, affordable, and culturally acceptable than the conventional drugs in developing countries. Thus, the increase in demand for standardization to ensure safety, purity and quality of medicinal plant. Standardization is a process of confirming herbal medicine identity and determination of its quality and purity. It involves botanical, physical, chemical and biological evaluations. These require application of different analytical methods and tools for standardization and phytochemical investigation of medicinal plants. The aim of this review is to explore analytical methods used for standardization of medicinal plants. A comprehensive web based literature review is employed in order to retrieve relevant information using international scientific databases including PubMed, Science direct, Web of Science, Google scholar. The review of selected 34 original published research articles were evaluated and summarized. The result this review showed that several analytical methods are employed and developed for standardization including chromatographic, TLC, GC, HPTLC and HPLC fingerprints, spectroscopic; UV, Fluorescence, MS, FT-IR, AAS and NMR are commonly applied techniques for different analytical purposes which are mainly used in physicochemical and phytochemical characterization of medicinal plants. Gel electrophoresis and DNA fingerprint are also applicable for botanical identification. The choice of analytical methods may depend on phytochemical, physicochemical nature of medicinal plant, selectivity and accuracy of analytical method. Development of selective analytical method is recommended for pesticide and Alfa toxin analysis to further ensure safety, quality and for complete standardization of medicinal plants.
A Comprehensive Review On Herbal Drug Standardization
American Journal of PharmTech Research
Now days more importance has been given to use medicinal plant products in healthcare system.it fulfills worldwide need of alternative medicine so traditional systems of medicine becomes more and more popular. It involves Proper combination of modern scientific techniques and traditional knowledge. The quality of herbal products is checked through stability testing studies which depends on various factors, such as temperature, humidity, light, oxygen, moisture, other ingredient , microbial contamination, trace metal contamination, leaching from the container, etc. Therefore such studies involves various types of evaluation such as chemical, physical, microbiological, therapeutic and toxicological studies can serve as an important tool in stability studies. Standardization of herbal drugs means confirmation of its identity, Quality and purity. The present study includes review of various standardization parameters with their effectivity towards the quality herbal drugs. Present article also overviews various well-designed methodologies, techniques such as Chromatography, Spectroscopic tech. for the standardization of herbal raw materials and herbal formulations.
Review Article: Standardization and Evaluation of Herbal Drugs is Need of the Hour in Present Era
2020
The herbal preparations are being into used from the primordial time throughout the world. Now, maximum people are shifted towards the Ayurveda for the treatment of any affliction. Herbs are also used as side products in the preparation of synthetic medicine. Traditional system of medicine has taken over the place worldwide, hence majority of products are formulated. The increased use of herbal drug, now concerning with its purity and quality of herbal raw material as well as finished product. Purity of the herbal constituent is the main problem faced by the herbal industries. To overcome this issue, WHO has published the certain guidelines for the standardization of the herbal material. To ensure the efficacy, purity and quality control processes, the personnel should himself supervise the standardization processes with uniform rules. The review represents the standardization parameters with the standards value of quality, purity and efficacy.
Quality Control and Evaluation of Herbal Product
International Journal for Research in Applied Science & Engineering Technology (IJRASET), 2023
Standardization of herbal formulation is important in order to assess of quality drug. The quality of herbal drug is the considerate all the factor which contribute directly or indirectly to the safety, effectiveness of the product Medicinal plant have been used to improve human health , increasing popularity global as drug , complementary and alternative medicines, food supplement, cosmetic as medical devices. The complexity of herbs and extracts supplied to such a wide range of markets and in different requlatory environment, raise major quality issues, increasing the need for appropriate analytical method for their identification, standardization &also for the detection of adulterants and contamination. Major limitation factors, such as herbal product naming, sampling and sample preparation are also discussed. The use of products of natural origin has remarkably increased in the global market, because of consumer becoming more health-conscious herbal medicines are considered safe by consumers and these product are generally less expensive than allopathic medicines.
Quality control of the traditional herbs and herbal products: a review
Future Journal of Pharmaceutical Sciences
Background Herbal medicinal material and product need is increasing, and with this increase in the need, it is very much an essential requirement to maintain the quality of them. Main body The quality of the herbals is altered by various physical, chemical, and geographical aspects which contribute to the quality of these materials. Apart from that, adulteration is also an increasing concern when it comes to herbal material quality. Various chemical and phytochemical test, analytical techniques, and hyphenated analytical techniques are used for determining the quality aspects of the herbal materials in the herbal pharmaceuticals. Conclusion These techniques can be used as quality control tool in assessing the quality of herbal materials and herbal pharmaceuticals.
RECENT ADVANCES IN HERBAL DRUG STANDARDIZATION – A REVIEW
Recently peoples are getting attracted towards herbal medicines due to many advantages. Herbal formulations have reached extensive acceptability as therapeutic agents for several diseases. Although, most of these applications are unorthodox, it is however a known fact that over 80% of the world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of abuse and adulteration of the products leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production ...
STANDARDIZATION AND EVALUATION OF HERBAL MEDICINES LATEST
Standardization of herbal medicines is the process of prescribing a set of standards or inherent characteristics, constant parameters, definitive qualitative and quantitative values that carry an assurance of quality, efficacy, safety and reproducibility. To do so, there must be clear technical methods by which this these objectives can be achieved. Current review has tried to compile and present available official methods of standardization of herbal medicines in simple and clear way to address such gap.
Traditional Approaches towards Standardization of Herbal Medicines-A Review
J. Pharm. Sci. …, 2010
Herbal drug technology is used for converting botanical materials into medicines, where standardization and quality control with proper integration of modern scientific techniques and traditional knowledge is important. Herbal medicines are gaining more and more attention all over the world, due to their long historical clinical practice and less side effects. This paper reviewed the traditional methods in the quality control of herbal medicines, including, the traditional chromatographic methods and comprehensive methods, such as fingerprint and multi-component quantification are emphasized; hyphenated techniques, like HPLC-MS, GC-MS. In a few word, the analysis and quality control of herbal medicines are moving towards an integrative and comprehensive direction, in order to better address the inherent holistic nature of herbal medicines.
An Updated Review on Quality Aspects of Herbal Drug and its Formulation
International Journal of Advanced Research in Science, Communication and Technology
Since a very long time ago, medicinal plants have been used to improve human health. Today, they are becoming more and more widely used as pharmaceuticals, supplementary and alternative therapies, food supplements, cosmetics, and, more surprising, medical gadgets. To assess a high-quality medicine, herbal formulations must be standardised. The total of all elements that directly or indirectly affect the safety, efficacy, and acceptability of the drug product makes up the quality of a herbal drug. The field of herbal drugs and formulations is developing quickly nowadays, and there is still much to learn about the standardisation of these products. However, the lack of a standardised parameter hurts herbal treatment. The major limitations are the lack of standardised raw materials, processing methods and of the final product , product formulation and lack of final products, product formulations, and lack of predetermined criteria for quality assurance. By applying current, suitable GM...