Unusual site of kaposi sarcoma after kidney transplantation (original) (raw)
2012, Iranian journal of kidney diseases
Kaposi sarcoma (KS) is the most common cancer after kidney transplantation in the Middle East countries. 1 The prevalence of KS in comparison with other tumors is also quite higher in Iranian recipients. 1,2 However, squamous cell carcinoma of the skin is the most common posttransplant malignancy in other reports. 1,3,4 Its incidence following kidney transplantation has steadily increased due to the long-term use of potent i m m u n o s u p p r e s s i v e d r u g s f o r p r e v e n t i o n of allograft rejection. 1,3,5 The prevalence of posttransplant KS varies in different geographic areas, most cases reported from Mediterranean descent, suggesting the importance of ethnic or environmental factors in its development. 1,3,6 Several investigators have found that the higher levels of anti-human herpesvirus-8 antibodies in the Middle East region where there is a higher prevalence of KS. 1 In the current issue of the Iranian Journal of Kidney Diseases a solitary laryngeal KS in a kidney transplant recipient is reported by Taheri and coworkers as an unusual involvement. 7 The patient who was a 40-year-old man presented with severe hoarseness after 21 months of his transplantation. It is important to note that 90% of kidney transplants with KS have skin lesions, mucosal lesions, or both. The oropharyngeal and conjunctival mucosa may be affected. Purely visceral involvement happens in 10% of recipients and their clinical manifestations are unusual. 1 Visceral disease predominantly affects the lymph nodes, gastrointestinal tract, and
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Transplantation, 2010
Background. Kaposi's sarcoma (KS) is an infrequent vascular neoplasm commonly diagnosed as an isolated cutaneous lesion that can involve other organs. So far, there are no data in the literature about the development of KS after intestinal transplant. Methods. In this study, the authors describe a case of "visceral KS" with pulmonary and intestinal involvement and perform a systematic literature review of case reports and single-center series identified in MEDLINE. Results. This case was a 42-year-old man, diagnosed with visceral KS 9 months after receiving an isolated intestinal transplant. He was successfully treated with a combination of sirolimus and liposomal doxorubicin and achieved an 18-month disease-free survival. A total of 54 cases from 27 manuscripts and the present case were analyzed in this study. The mean time from transplant to diagnosis was 17.2 months. Lungs and gastrointestinal tract were the main organs involved. Immunosuppressants were discontinued in two of the three (66.7%) cases, and sirolimus was added in eight cases. Doxorubicin was used in 12 cases. In a univariate analysis, the use of Tacrolimus, type of transplant, and presence of cutaneous KS seem to be the significant predictors of response to therapy and survival; the addition of doxorubicin showed a reduction in graft loss. Conclusions. Treatment of KS in posttransplant patients should be designed aiming to obtain a complete response, irrespective of the organ affected. Only recipients who are able to achieve a sustained response would be able to obtain long-term disease-free survival.
Sarcoma de Kaposi pós-transplante hepático: relato de caso
Revista de Medicina, 2022
Introduction: Kaposi's Sarcoma is a multicentric malignant neoplasm characterized by the development of purple tumors, which can be seen on the skin and subcutaneous tissue and on viscera. The objective of this study was to report a case of Kaposi's Sarcoma after liver transplantation, considering the rarity of this event. Method: The research instrument used to conduct this report was the case study, with collection of information from the patient's physical record. Case report: A 28-year-old man with a history of using Tacrolimus for three years due to liver transplantation, presented abdominal pain associated with diarrhea, and was diagnosed with Kaposi's Sarcomi through histopathological examination of intestinal polyp and referred for chemotherapy treatment. Final considerations: Patients who were submitted to solid organ transplants and treated with immunodepressive medications should have any new symptoms carefully investigated to allow an early diagnosis of neoplasia.
Kaposi sarcoma after kidney transplantation
Iranian journal of kidney diseases, 2007
Skin cancers are the most common tumors among transplant recipients who receive immunosuppressive agents. Kaposi sarcoma (KS) is one of the most common malignancies to occur in kidney transplant recipients, especially in the Middle East countries. Its prevalence in comparison with other neoplasms is also relatively higher in Iran (> 35%). The KS-associated herpesvirus or human herpesvirus 8 is a newly discovered herpesvirus found in all forms of the KS including those among immunosuppressed transplant recipients. Kaposi sarcoma usually regresses after withdrawal or reduction of immunosuppressive agents. A wide variety of therapies have been used for KS, including radiotherapy and administration of interferon and different chemotherapeutic regimens. Sirolimus exhibits antiangiogenic activity related to impaired production of vascular endothelial growth factor and limited proliferative response of endothelial cells to the stimulation by vascular endothelial growth factor. Therefore...
Dermatology, 2010
A 63-year-old Swiss patient developed acquired nodules on his right palm after 3 localized surgeries, called ‘needle fasciotomy’, for Dupuytren’s disease. Kaposi’s sarcoma (KS) was diagnosed in a biopsy of a nodule. A positive immunolabeling and serology for human herpesvirus 8 has been found, but human immunodeficiency virus and hepatitis C identification remained negative. The nodules were limited to the surgically traumatized area. This first report of a nonimmunocompromised patient developing a KS after repeated surgeries in a unique peculiar localized area with a dense lymphatic network sustains the hypothesis that tissue alterations involving the lymphatic system could play a central role in the occurrence of KS.
European Journal of Case Reports in Internal Medicine, 2015
Kaposi's sarcoma (KS) is one of the most frequent neoplastic diseases in patients infected with human immunodeficiency virus (HIV). The authors report the case of a 40-year-old male with ascites, peripheral edema and peritoneal carcinomatosis secondary to a gastric KS related to human herpes virus type 8 (HHV-8). The patient had severe immunodeficiency, with a TCD4+ count of 86 cells/µl and newly diagnosed acquired immunodeficiency syndrome. His clinical condition rapidly deteriorated, with multiorgan failure, and he died without the possibility of initiating antiretroviral therapy or chemotherapy. To the authors' knowledge, carcinomatosis is a rare feature in KS. LEARNING POINTS • In a patient with acquired immunodeficiency syndrome (AIDS) presenting with Kaposi sarcoma (KS) with skin involvement, the possibility of visceral disease must be considered, even if asymptomatic. • Multicentric Castleman disease (MCD) and primary effusion lymphoma must be considered in every HIV-infected patient with anasarca, poliadenopathy and hypoalbuminemia. • KS may present in a disseminated form and gastrointestinal involvement may led to ascites and carcinomatosis.
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