Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain (original) (raw)

The study investigates the effects of thyroid hormone deficiency and replacement on RC3/neurogranin expression in the rat brain, specifically through in situ hybridization techniques. Findings reveal that RC3 mRNA expression is thyroid hormone-dependent and undergoes distinct phases during development, with noted alterations in hypothyroid conditions and subsequent restoration following hormone treatment. The research underscores the critical role of thyroid hormones in neuronal maturation and gene expression regulation within the brain.