Castleman disease. A report of six cases (original) (raw)
Related papers
Castleman Disease: A Rare and Intriguing Malady: A Case Series
The Indian Journal of Chest Diseases and Allied Sciences
Castleman disease (CD), first described by Benjamin Castleman as angiofollicular mediastinal lymph-node hyperplasia, is a rare benign lymphoproliferative disorder with varied modes of presentation. Its common presentation within the mediastinum misleads the clinician and merits special attention since it is essentially a diagnosis of exclusion. We are sharing our experience with three patients, within a relatively short period of 2 years. All three presented with a mediastinal mass, however, each of them came with an entirely different clinical scenario and diagnosis. All three were successfully operated and Castleman disease [hyaline-vascular (HV) type] was diagnosed only after the final histopathology.
A Case Report on Unicentric Form of Castleman’s Disease
Indian Journal of Case Reports, 2020
Castleman's disease, also known as angiofollicular lymph node hyperplasia, is a heterogeneous group of lymphoproliferative disorders. It is a rare disease and difficult to diagnose preoperatively. Localized Castleman's disease is almost always hyaline vascular variant type. We present the case of a 30-year-old male with swelling over the left side of the neck for 10 years which was diagnosed as Castleman's disease on histopathology.
Acta bio-medica : Atenei Parmensis, 2011
Castleman's Disease is a rare tumour involving lymph node tissues; a case of benign localized disease and a case of rapid progressive multicentric disease are reported. Case report 1: A 19-year-old man presented with four months of hypogastric and left iliac pain. Castleman's Disease was suspected after CT-scan. A CT-guided fine-needle biopsy of the lesion was performed revealing hyaline vascular type Castleman's Disease. The patient underwent open surgery with radical excision of the lesion. No adjuvant therapy was performed after surgery. The patient is alive and disease-free after 24 months. Case report 2: A 58-year-old woman presented with a right axillary palpable lymph node and vague abdominal discomfort. Abdomen CT demonstrated hepatosplenomegaly associated with adenopathy at the hepatic hilus and splenic hilus; dilatation of intra-hepatic biliary ducts was present. The axillary node was excised, the mass at hepatic hilus was biopsied. The diagnosis was Castleman&...
Hyaline vascular Castleman's disease: a case report and brief review of the literature
The Netherlands journal of medicine, 2002
We describe a 27-year-old female with a mesenterial localisation of the hyaline vascular type of Castleman's disease. A review of the literature is given with emphasis on the different pathogenesis of the subtypes. The hyaline vascular type is a disorder of stromal cells, which can be complicated by the development of soft tissue sarcomas. The plasma cell type is a plasma cell disorder with elevated levels of interleukin-6 (IL-6). In the multicentric type, infection with human herpes virus-8 (HHV-8) plays an important role in the pathogenesis. The development of Kaposi's sarcoma and some lymphomas are related to the presence of HHV-8. As the different subtypes have a different pathogenesis they should be regarded as distinct diseases.
Mixed Hyaline Vascular and Plasma Cell Type Castleman's Disease: Report of a Case
Castleman's disease (angiofollicular lymphoid hyperplasia) includes a heterogeneous group of lymphoproliferative disorders. The cause of this disease remains uncertain. There are two types of localized Castleman's disease: the more common hyaline vascular and the plasma cell types. Mixed variant is an uncommon localized lesion in general population. The lesions can occur in any part of the body that contains lymphoid tissue, although seventy percent are found in the anterior mediastinum. We report a thirty years old boy with Castleman's disease who presented with fever, anorexia, weight loss, sweating, anemia and abdominal mass. The histologic examination of the biopsy specimens revealed a mixed hyaline vascular and plasma cell type of Castleman's disease.
An unusual presentation of Castleman's disease
Respirology, 2010
Castleman's disease is one of the heterogeneous group of lymphoproliferative disorders of unknown aetiology. It commonly presents as a mediastinal mass. It can be unicentric involving only a single site, or multicentric involving multiple sites. We report a patient with unicentric Castleman's disease, in which the mass was located in the posterior mediastinum and accompanied by a massive pleural effusion, which is extremely rare in unicentric disease. This case report highlights the imaging techniques used in the differential diagnosis and surgical considerations due to the hypervascular nature of the tumour.
Castleman’s Disease: Due to a Rare Intraabdominal Location
Forbes Journal of Medicine, 2021
Castleman disease (CD) is a rare benign disease with unknown etiology. It is also called angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, lymph node hamartoma, benign giant lymphoma. Histologically, it is classified as hyaline vascular and plasma cell variant, but rarely features of two types can coexist. Most of the cases with unisentric disease are hyaline vascular and most of the cases with multicentric disease are in plasma cell histological type. Although it is frequently located in thorax, it can be found throughout the body. Salivary glands, lungs, pancreas, larynx, parotid gland, meninges, and even limb muscles can be affected as extralymphatic spread. Since it is localized in the middle and anterior mediastinum in the thorax, it should be differentiated from mediastinal autoimmune and neoplastic diseases. In this case report, we aimed to present the radiological findings of a CD case with a rare intraabdominal location.
Castleman's Disease: A Rare Case Report
IOSR Journals , 2019
Castleman Disease (CD) is a rare, heterogeneous group of hyperimmune lymphoproliferative disorders,not very familiar to surgeons.It is characterized by non-neoplastic lymph node hypertrophy. Its incidence and etiology are not known,but has been found in association with Kaposi's Sarcoma.Unicentric Castleman Disease (UCCD) at one end of the spectrum is a localized disease, with little or no systemic symptoms. It may be an incidental radiological finding or detected while investigating for a symptomatic lymph node mass.Multicentric Castleman Disease (MCCD) is a more serious systemic condition, often associated with constitutional symptoms. Human Herpes Simplex Virus 8 (HHV8) associated MCCD is a major subgroup occurring in immunocompromised individuals due to the viral trigger. We report a case of a 21 year old male presenting with a history of swelling in the right side of the neck at level 2 since 7 months and another lymph node since 2 months at level 3 station for which he was on Anti-tubercular therapy based on initial FNAC report.There was no decrease in the size of the swellings and a repeat FNAC showed a suspicion of Hodgkin'sdisease from level 2 station lymph node.Subsequently,excision and biopsy was done and Histopathological examination revealed Castleman's Disease.Usg abdomen and Chest x ray were normal.Surgery is the primary treatment and has good long term prognosis.Awareness among surgeons and diligent work-up is a must for early diagnosis and best outcome.
Castleman's Disease Clinical Case and Literature Review
Scholars Journal of Medical Case Reports, 2021
Castleman's disease or angiofollicular lymphoid hyperplasia is a rare condition of uncertain cause. It poses a diagnostic and therapeutic problem. We report the clinical case of a 58-year-old patient who presents LUTS associated with microscopic hematuria with an abdominopelvic CT scan in favor of a 20mm retroperitoneal tissue lesion at the lower pole of the right kidney which is enhanced by injection of PC posing a differential diagnosis problem with the other retroperitoneal masses. The biopsy under scanner was not performed given the difficult localization of the lesion, it was finally lumpectomy with pathological study that made it possible to make the diagnosis. The immediate and remote post-operative consequences were favorable. Through this clinical case and through a literature review, we analyze the epidemiological, diagnostic and therapeutic aspects of this rare pathology.