Reconciling Qualitative, Abstract, and Scalable Modeling of Biological Networks (original) (raw)

Predicting the behaviors of complex biological systems, underpinning processes such as cellular differentiation, requires taking into account many molecular and genetic elements for which limited information is available past a global knowledge of their pairwise interactions. Logical modeling, notably with Boolean Networks (BNs), is a well-established approach which enables reasoning on the qualitative dynamics of networks accounting for many species. Several dynamical approaches have been proposed to interpret the logic of the regulations encoded by the BNs. The synchronous and (fully) asynchronous ones are the most prominent, where the value of either all or only one component can change at each step. Here we prove that, besides being costly to analyze, these usual interpretations are not adequate to represent quantitative systems, being able to both predict spurious behaviors and miss others. We introduce a new paradigm, the Most Permissive Boolean Networks (MPBNs), which offer t...

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact