Electrophysiological characterisation of α-MHCcells (original) (raw)

2011

Abstract

<b>Copyright information:</b>Taken from "Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes"Genome Biology 2007;8(4):R56-R56.Published online 11 Apr 2007PMCID:PMC1896009. Characteristic cardiac action potential (APs) of puromycin purified α-myosin heavy chain (MHC)cells. Most APs had a typical cardiac AP morphology but could not be further specified. Only few APs exhibited typical features of pacemaker-like, atrial-like, or ventricular-like APs. The minimal diastolic potential was -60.2 ± 1.1 mV. The maximal upstroke velocity was 22.9 ± 2.2 V/s. APD, APDand APD(AP duration from maximum to 90%, 50% and 20% repolarization) were 96.4 ± 4.2 ms, 71.1 ± 3.9 ms, and 41.3 ± 2.6 ms, respectively. Representative recordings showing the effect of carbachol (1 μmol/l) and isoproterenol (1 μmol/l) on the spontaneous AP frequency. Statistical analysis of the effects of carbachol (1 μmol/l) and isoproterenol (1 μmol/l) on the spontaneous AP frequency. Carbachol caused a decrease whereas isoproterenol increased the spontaneous AP frequency.

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