Chapter 8 Ibogaine in the treatment of heroin withdrawal (original) (raw)

Ibogaine, a naturally occurring psychoactive alkaloid derived from the Tabernanthe iboga plant, has shown potential in aiding detoxification from heroin through anecdotal evidence and limited case reports. While pharmacological research demonstrates its capacity to reduce opiate withdrawal symptoms, the precise mechanisms remain unclear, particularly regarding its metabolite, noribogaine. This chapter highlights pharmacokinetic parameters of ibogaine and noribogaine in humans and animals, offering insights into their roles in heroin withdrawal treatment.