Nucleic Acids Research (original) (raw)
2008, Nucleic Acids Research
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Nucleic Acids Research Advance Access published November 14, 2007 The 20 years of PROSITE
2007
PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. In this article, we describe the implementation of a new method to assign a status to pattern matches, the new PROSITE web page and a new approach to improve the specificity and sensitivity of PROSITE methods. The latest version of PROSITE
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A zone electrophoresis apparatus using ultraviolet optics has been constructed to study nucleic acids at concentration leas than 0.004%. Native DNA has a mobility about 15% higher than denatured DNA over a range of conditions of p H and ionic strength. A study of a molecular weight series of DNA indicates that the mobility is constant in the molecular weight range of 2. 5 X 106 to 1.3 X 108. DNA mobilities change in the expected way with pH but the fractional change in mobility is less than the change in charge calculated by titration curves. A small decrease in mobility accompanies an increase in ionic strength. RNA's from various sources have mobilities slightly lower than denatured DNA except for s-RNA which travels slightly faster. DNA's from different sources have closely similar mobilities.
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