THE EFFECT OF POLYETHYLENE GLYCOL (PEG) COATING ON THEMAGNETO-STRUCTURAL PROPERTIES AND COLLOIDAL STABILITY OFCo0.8Mg0.2Fe2O4 NANOPARTICLES FOR POTENTIAL BIOMEDICALAPPLICATIONS (original) (raw)
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INDONESIAN JOURNAL OF APPLIED PHYSICS
Nanocrystalline mixed spinel ferrite of Co0.5Ni0.5Fe2O4 magnetic nanoparticles (MNPs) has been successfully synthesized by coprecipitation method and encapsulated by PEG-4000 with various concentrations. X-Ray Diffraction (XRD) patterns showed that nanoparticles contained Co0.5Ni0.5Fe2O4 spinel ferrite with crystallite size of 14.9 nm. After PEG-4000 encapsulation particles size decreased became 7.7 nm. Interaction Co0.5Ni0.5Fe2O4 nanoparticles with long chain PEG-4000 caused the crystal growth trap. Lattice parameter and X-Ray density have no significant difference after encapsulated PEG-4000. The coercivity (𝐻𝑐) of Co0.5Ni0.5Fe2O4 was 214 Oe. The 𝐻𝑐 decreased after PEG-4000 encapsulation became 127 Oe, which is due to the decrease of crystallite size. The maximum magnetization (Mmax) of Co0.5Ni0.5Fe2O4 was 12.0 emu/g, and decreased after PEG-4000 encapsulation to 11.7 emu/g, because PEG-4000 is paramagnetic. After the concentration of PEG-4000 increased, then the amount of paramag...
Journal of Physics: Conference Series, 2019
In this study, we have functionalised cobalt ferrite (CoFe2O4) nanoparticles (NPs) by doping with a natural bio-mineral magnesium (Mg) and coating with three polymers to enhance biocompatibility and feasibility for therapeutic applications. The glycol-thermal method was employed to synthesise CoFe2O4 and Mg0.5Co0.5Fe2O4 NPs. The latter NPs were functionalised with chitosan (CHI), poly-ethylene glycol (PEG) and poly-vinyl alcohol (PVA) to produce CHI-Mg0.5Co0.5Fe2O4, PEG-Mg0.5Co0.5Fe2O4 and PVA-Mg0.5Co0.5Fe2O4. The structure and morphology of NPs were characterized using transmission electron microscopy (TEM), high resolution TEM (HR-TEM), X-ray diffraction (XRD), Fourier transform infra-red (FTIR) spectroscopy and nanoparticle tracking analysis (NTA). Magnetic measurements were carried out using a vibrating sample magnetometer (VSM). XRD patterns confirmed inverse cubic spinel phase structure typical of ferrite NPs. NPs exhibited spherical shape with average size diameters of rangin...
2013
Here in this paper, we report how the bio-compatible polymer poly ethylene glycol (PEG 20000) controls the size of the magnetite nanoparticles synthesized by the simple cost effective co-precipitation method. The size of the particles calculated by Scherrer formula from the Powder X-ray Diffraction (PXRD) reports clearly depicts this. The Fourier Transform Infrared spectroscopy (FT-IR) studies confirm the bonding of the PEG molecules with the magnetite nanoparticles. The Scanning Electron Microscope (SEM) and EDAX results confirm the surface morphology and the elemental composition. The saturation magnetization values of the particles also increases as seen from the Vibrating Sample Magnetometer (VSM) results. These particles can be very well used in various biomedical applications.
Biocompatibility Studies of Functionalized CoFe2O4 Magnetic Nanoparticles
2011
CoFe2O4 nanoparticles of different sizes were synthesised by controlling the digestion time using precipitation method and were characterised by X-ray diffraction, transmission electron microscopy, Dynamic light scattering, and vibrating sample magnetometer. The average crystalline size increases from 13.9 to 19 nm as the digestion time is increased from 1.3 to 120 minutes. The CoFe2O4 nanoparticles were coated with two biological polymers, namely polyvinyl alcohol (PVA) and polyethylene glycol (PEG) with various ratios to enhance their biocompatibility. Coated nanoparticles were analysed for their cytotoxicity by MTT assay against 3T3-L1 adipocytes. Coated nanoparticles were found to be less cytotoxic when compared to uncoated one. The cells viability decreased as the concentration of the polymer (either PVA or PEG) coating increased. Cell viability decreases as the concentration of nanoparticle increases. At 5 μg/ml the cell viability with PEG coated nanoparticles (1:4) was 92.5%, PVA coated nanoparticles (1:4) was 82.7% and uncoated was 46.4%. As the ratio of biological polymers (PVA and PEG) to nanoparticle increases, the viability of the cell increases. The difference between the effect of these two polymers increases as the concentration of the nanoparticle decreases. The anti-inflammatory properties of these nanoparticles were determined by RTPCR by measuring the two pro-inflammatory cytokines (namely tumor necrosis factor and IL6). TNF-and IL6 were upregulated by 3.57-& 2.86 folds their base level with uncoated nanoparticles. Whereas it was upregulated by 1.54-& 1.68-folds with PEG coated and 1.9-& 2.18-folds with PVA coated nanoparticles. Thus the coated nanoparticles can be used for further biological experiments including magnetic resonance imaging, and in targeted drug delivery systems for various diseases.
ACS Omega, 2021
Ferrites are one of the most studied materials around the globe due to their distinctive biological and magnetic properties. In the same line, anisotropic MnFe 2 O 4 nanoparticles have been explored as a potential candidate possessing excellent magnetic properties, biocompatibility, and strong magnetic resonance imaging (MRI) properties such as r2 relaxivity for magnetic field-guided biomedical applications. The current work reports the synthesis and morphological evolution of MnFe 2 O 4 nanocubes (MNCs) in a hydrothermal process using different volume ratios of water and ethanol. The synthesis protocol was designed to influence the properties of the ferrite nanocubes, for example, the variation in surface tension, dielectric properties, and the ionic character of the solvent, and this has been achieved by adding ethanol into water during the synthesis. Pristine MnFe 2 O 4 is formed with well-defined cubic to irregular cubic shapes with the addition of ethanol, as evidenced from XRD, field emission scanning electron microscopy, and porosity measurements. MNCs have been investigated for magnetic hyperthermia and MRI applications. Well-defined cubic-shaped MNCs with uniform size distribution possessed a high saturation magnetization of 63 emu g −1 and a transverse relaxivity (r2) of 216 mM −1 s −1 (Mn + Fe). Furthermore, the colloidal nanocubes showed concentration-dependent hyperthermic response under an alternating magnetic field. The MNCs are biocompatible but advantageously show anticancer activities on breast cancer MCF 7 and MDA-MB-231 cells.
Ceramics International, 2015
The coating of Polyethylene Glycol (PEG) on zinc substituted manganese ferrite nanoparticles has been reported in the present study. Single phase nanoferrites bearing the chemical formula Mn (1 À x) Zn (x) Fe 2 O 4 (0.0 r x r1.0) were produced under low reaction temperature of 75 1C and their morphological, structural and magnetic characterizations were performed. The prepared ferrites were characterized using X-ray diffraction (XRD), field emission scan electron microscopy images (FE-SEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM) techniques. XRD revealed the formation of spinel single-phase structure for the samples with Zn-content. The crystallite sizes estimated using Scherer formula were in the range 4.50-15.89 nm. The characteristic bands of PEG as observed in its Fourier transform infrared spectrum technique were also present in PEG layer on Mn-Zn ferrite nanoparticles, hence confirming its presence. The presence of PEG on Mn (1 À x) Zn (x) Fe 2 O 4 nanoparticles, spherical formation of PEG coated Mn (1 À x) Zn (x) Fe 2 O 4 nanoparticles and reduced agglomeration in the Mn (1 À x) Zn (x) Fe 2 O 4 nanoparticles were revealed by FE-SEM. The measurements of magnetic properties at room temperature by VSM showed that all samples behaved superparamagnetic with magnetization (M) and coercivity in the range of 1.86-20.66 emu/g and 12.922-30.253 Oe, respectively. The M-H loop of all the samples is narrow with low value of coercivity and retentivity; indicating the superparamagnetic nature of these samples.
Fizika tverdogo tela, 2023
The results of studies of the properties of co-deposition of magnetic nanoparticles (MNPs) of Co 1−x Znx Fe 2 O 4 spinel ferrites synthesized (at x = 0.0; 0.1; 0.2; 0.4; 0.6) in order to synthesize magnetic particles for biomedical applications. X-ray diffraction (XRD), raman spectra, magnetic measurements and Mossbauer spectroscopy (MS) were used to study the Co 1−x Znx Fe 2 O 4 MNPs. It was found that the synthesized MNPs Cox Zn 1−x Fe 2 O 4 are singlephase. According to the results of XRD measurements, it was found that the average sizes of crystallites are 13 nm for CoFe 2 O 4 (x = 0) and, with an increase in the Zn concentration, they decrease to 7 nm for Co 1−x Znx Fe 2 O 4 (x = 0.6), which is consistent with the Mössbauer data, which showed that the sizes of crystallites vary from 14 to 8 nm. In the raman spectra of the Co 1−x Znx Fe 2 O 4 MNPs in the region of ∼ 620 cm −1 , splitting of the A 1g , line is observed, indicating that the studied particles have an inverse spinel structure. The change in the ratio between intensities of A 1g (1) and A 1g (2) peaks is indicative of a significant redistribution of Co 2+ and Fe 3+ cations between tetrahedral and octahedral positions in Co 1−x Znx Fe 2 O 4 MNPs as the quantity of Zn increases, which is confirmed by the Mössbauer data. It is found that small sizes of MNPs result in a strengthening of the effects of size and an effect of surface on the magnetic structure of the surface layer. The MS analysis has shown that there is a layer on the MNP surface, the magnetic structure of which is different from from the structure of the crystallite volume. With increase in the quantity of Zn ions thickness of this layer increases and at x = 0.6 the particle becomes completely paramagnetic. Mössbauer studies have shown that Co 0.8 Zn 0.2 Fe 2 O 4 (x = 0.2) particles are in the superparamagnetic state and their magnetic blocking temperature is ∼ 315 K, which is the most acceptable for the treatment of cancer by the magnetic hyperthermia method.
Effect of biomimetic templates on the magnetostructural properties of Fe3O4 nanoparticles
In this study, water dispersible iron oxide nanoparticles (IONPs) were synthesized in three different templates using a combination of proteins (collagen and bovine serum albumin), amino acids (glycine and glutamic acid) and a biocompatible polymer (poly vinyl alcohol). A stringent control on the morphology of IONPs that is reproducible and scalable at ambient conditions is obtained. Detailed structural characterization and the template effect on magneto-structural properties of IONPs have been studied. Magnetic measurements showed variation in magnetic properties and relaxation behavior with change in the chemical environment (the attachment of surface ligands confirmed from the Fourier transform infrared spectra); M¨ossbauer studies revealed monopole and magnetic hyperfine interactions playing an important role that could be attributed to template dependency. The increase of particle size coupled with decrease in hydrodynamic diameter decreases demagnetizing interactions between nanoparticles which increase the specific absorption rate in in vitro hyperthermia, thus the highest specific absorption rate (139 Watts per g) observed in template 1. Magnetic resonance imaging (MRI) studies also showed transverse relaxivity of 543.9 ml s1 mg1 for nanoparticles in template 1. Considering the anisotropy energy barrier, particle size and hydrodynamic diameter we conclude that template 1 is the best for potential applications in biomedicine
In the present study, the influence of the organic stabilizers on the formation of magnetic iron-oxide nanoparticles was investigated. Polyethylene glycol (PEG), dextran (DEX), and chitosan was chosen as biocompatible surface modification agents for obtained magnetic nanoparticles. The structure of the coated Fe3O4 nanoparticles was learned by the X-ray diffraction and Fourier-transform infrared spectroscopic methods. It was explored that the PEG coated magnetic nanoparticles have relatively larger crystallite sizes, which indicate a more ordered crystal structure of these nanoparticles. Furthermore, FT-IR analysis showed that the Fe3O4-PEG system possesses a stronger nanoparticle-stabilizer interaction at the supramolecular level. This study emphasizes the significance of optimizing the surface properties of magnetic nanoparticles when using them in biomedical applications.