Relationship between higher Serum ferritin levels, Insulin resistance marker and components of metabolic syndrome in Men and Women in west part of India (original) (raw)
Related papers
Clinical Endocrinology, 2003
BACKGROUND Previous studies have suggested that serum ferritin is one of the components of the insulin resistance syndrome in Caucasians. Because serum ferritin levels differ significantly between men and women, variation in the role of ferritin in insulin resistance between the sexes, particularly in Asian populations, is still unknown. OBJECTIVE To examine whether the association between serum ferritin and insulin resistance differs between men and women in randomly selected non-diabetic Chinese subjects. DESIGN A retrospective study. PATIENTS Four hundred and seventeen non-diabetic Chinese subjects (140 men and 277 women) were studied. MEASUREMENTS Fasting plasma glucose, insulin, lipoproteins and serum ferritin concentrations, as well as plasma glucose and insulin responses to a 75-g oral glucose test (n = 219), were determined. RESULTS Fasting serum ferritin concentrations (mean ± ± ± ± SEM) were significantly higher in men than in women (504 ± ± ± ± 33 vs. 242 ± ± ± ± 18 pmol / l, P < 0•001). In women, fasting serum ferritin concentrations correlated significantly with age, body mass index (BMI), amount of body fat, fasting plasma glucose, insulin, cholesterol, triglyceride concentrations, glucose response to an oral glucose load, and homeostasis model assessment (HOMA) of insulin resistance but not with blood pressure, high density lipoprotein (HDL) cholesterol levels and insulin response to oral glucose. On the contrary, none of the above anthropometric and metabolic variables was related to fasting serum ferritin levels in men. HOMA insulin resistance increased progressively across three different tertiles for measured serum ferritin concentrations in women (P < 0•003). In men, HOMA insulin resistance levels were not different among three differing measured serum ferritin levels (P = 0•424). Adjustment for age, BMI and menopause status did not change the significant relationship between HOMA insulin resistance and serum ferritin in women. CONCLUSIONS We observed that a relationship between serum ferritin levels and insulin resistance exists in women but not in men. This sexual dimorphism merits further investigation.
Clinical & Medical Biochemistry: Open Access, 2016
Background: Raised serum ferritin levels are associated with insulin resistance, type 2 diabetes mellitus, prediabetic stage, metabolic syndrome (Mets) and cardiovascular risk. The association between Serum ferritin and HbA1c levels with individual components of metabolic syndrome and obesity are unclear. Objectives: The present study was designed to investigate the relationship between serum ferritin levels, fasting Blood glucose levels, waist Hip ratio, fasting insulin levels, homeostasis model assessment (HOMA-IR), and lipid profile in previously diagnosed type 2 diabetes mellitus patients, newly diagnosed patients, impaired fasting glucose subjects and healthy subjects and relationship among iron stores, the metabolic syndrome, and insulin resistance in premenopausal women, postmenopausal women and men. Subjects and methods: 1058 participants included in this study out of them 365 patients with previously diagnosed type 2 diabetes mellitus having poor glycemic control and good glycemic control, 144 patients with newly diagnosed type 2 diabetes mellitus, 189 participants with impaired fasting glucose levels and 360 healthy participants. Fasting blood glucose, Serum ferritin, serum insulin, HbA1c waist hip ratio, and lipid parameters were estimated and Homeostasis Model Assessment-Insulin resistance (HOMA-IR) was calculated. Results: Dichotomizing ferritin concentration in to <300 and >300 ng/ml for men and <150 and >150 ng/ml for women, the odd ratios for newly diagnosed diabetes were 4.94 (95% CI 3.05-8.01) for men 3.61 (2.01-6.48) for women. All multiple linear regression coefficients between ferritin concentration and concentration of insulin, glucose, and glycosylated hemoglobin were positive and significant for men and postmenopausal women. Conclusion: On basis of present studies results, it is concluded that hyperferritinaemia and iron overload may be the primary cause of insulin resistance and metabolic syndrome before overt type 2 diabetes mellitus.
International Journal of Scientific Reports, 2016
The health of girls and women is affected by developmental, psychological and physiological age. Women's lives are marked by a continuous transition from intrauterine life, infancy, adolescence, menarche, reproductive life, menopausal transition, postmenopausal to the frail elderly life. Across the life span of a woman, menopause probably has the greatest impact on the health of women. 1 Menopause is the phase of aging during which women passes from reproductive to nonreproductive stage. 2 Oestrogen deficiency is a major occurrence in postmenopausal women and is associated with symptoms and diseases that are of increasing importance to women's health. Physiological and biochemical changes that alter the general health of women are seen in menopause which includes an increase in adiposity, which is a risk factor for developing insulin ABSTRACT Background: Physiological and biochemical changes that alter the general health of women are seen in menopause which include increase in adiposity and elevated serum ferritin. There is a dearth of information on the prevalence and common risk factors of MS and their association with iron stores of the body among postmenopausal women (POMW) in Enugu. Hence, this study was carried out to determine the prevalence of metabolic syndrome, the most prevalent components of metabolic syndrome and its relationship with serum ferritin level in postmenopausal women in Enugu, Nigeria. Methods: The study was a cross sectional study, carried out from February to August 2013 among two hundred and twenty four (224) apparently healthy postmenopausal women aged 40 to 83 years. Metabolic syndrome was defined using National Cholesterol Education Programme, Adult Treatment Panel III criteria. Results: The most frequent components of metabolic syndrome (MS) seen among the subjects were high waist circumference (WC) (70.1%), high blood pressure (66.5%) and low high density lipoprotein cholesterol (25.4%). The prevalence of metabolic syndrome among the women was 29.0% while the mean level of serum ferritin of subjects with metabolic syndrome showed no significant (p >0.05) difference when compared to subjects without MS. Conclusions: The most frequent cluster of the risk factor of MS in the population studied was high WC, high blood pressure and low high density lipoprotein cholesterol (HDL). Although serum ferritin is slightly associated with FPG and WHR, it may not be used as diagnostic tool for MS in the group studied.
Journal of emerging technologies and innovative research, 2018
Ferritin is one of the key proteins regulating iron homoeostasis and is a widely available clinical biomarker of iron status. Elevated Serum Ferritin (SF) levels have been reported to be associated with several metabolic Disorders (MetS). Individual with highest SF were more likely to consume high amount of animal protein, betel nuts and lower amount of carbohydrates, compared with individual with lowest amount of SF. Association among serum Ferritin and metabolic syndrome compared by metabolic syndrome score(MSS). Results will highlight the crucial role of serum Ferritin level in health of people in Vadodara. Keywords-Serum Ferritin (SF), metabolic Disorders (MetS), metabolic syndrome score (MSS) iron homeostasis, biomarker. ________________________________________________________________________________________________________ I. INTRODUCTION Normal physiological process requires iron as vital important metal [1], and many metabolic processes such as oxygen transport, DNA synthesis, and electron transport done by this ubiquitous metal.[2]. Iron deficiency is one of the most prevalent nutrient disorders. It affects approximately two billion people worldwide and is the most common cause of anemia (WHO) [3]. Ferrous iron combines with apoferritin and is stored by ferritin in many organisms in a form of serum ferritin [4]. As an excessive accumulation of ferritin can increase the concentration of catalytically active free iron, and serum Ferritin concentration has been considered a possible risk factor of various chronic diseases including cancer, cardiovascular disease, diabetes, and essential hypertension, in which oxidative stress is closely involved in pathogenesis [5-9]. Newly research conducted on serum Ferritin concentration and MetS in all over the world. Though, the findings for the association of MetS and serum Ferritin concentration are still being debated because of variation across the studies. [14-17] .The present study has been done to investigate the association between MetS and its components and serum Ferritin concentration in adult barodian men and women aged 20 and above. II. MATERIALS AND METHOD 1. Study details Research subjects of a retrospective study were classified by gender and by age into 20∼29 years, 30∼39 years, 40∼49 years,
Proceedings, 2024
Introduction: Diabetes mellitus is a metabolic disorder which is caused by either deficiency of insulin or its disturbed action on peripheral receptors. Globally it is estimated that 451 million peoples were suffering from Diabetes mellitus type 2 in 2017 and this burden will rise to 693million in 2045.The relationship between diabetes mellitus and serum ferritin levels is intricately linked, sharing a common intersection in the liver where both glucose metabolism and iron metabolism converge. Aims and Objectives: To measure the serum ferritin levels among residents of Hyderabad with type 2 Diabetes Mellitus. Place and Duration of study: The study was conducted in the Outpatient Department (OPD) of Liaquat university Hospital from June 2022 to August 2022 (3 months). Material and Methods: The study consists of 100 subjects divided into two groups, a control group consists of 50 normal healthy people with normal fasting glucose below 100mg/dl and a Case group consists of 50 patients with fasting glucose level more than 125 mg/dl according to World Health Organization criteria. Their Serum ferritin levels were evaluated using the ELFA method, employing a commercially available kit supplied by Roche Cobas Integra. The results were analyzed on the software Graph Pad Prism 9, p-value 0.05was taken as significant. Results: The frequency of Type 2 Diabetes mellitus was significantly higher in patients with increased serum ferritin levels (P=0.001) with an odds ratio of 1.838 , a sensitivity/specifity value of (0.50/0.56) and a robust likelihood ratio of 2.25. Conclusion: The study underscores a potential link between elevated serum ferritin and Diabetes Mellitus Type-2.
Serum ferritin is associated with markers of insulin resistance in Japanese men but not in women
Metabolism, 2013
Objective. Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR. Our aim was to examine the relationship between serum ferritin concentrations and IR markers in the Japanese population. Materials/Methods. We analyzed data (n = 493) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68 years. Fasting serum ferritin and insulin levels and fasting plasma glucose levels were determined, and the homeostatic model assessment of IR (HOMA-IR) was calculated. Multiple regression analysis was performed with adjustments for demographic and lifestyle factors, body mass index and serum C-reactive protein.
Metabolism, 2011
We examined the association of serum ferritin levels with metabolic syndrome (MS) and diabetes mellitus in a representative sample of the adult South Korean population using data from the 2008 Korean National Health and Nutrition Examination Survey. We conducted a cross-sectional study of 6311 adults older than 20 years who participated in the 2008 Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low highdensity lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Diabetes mellitus was defined as fasting glucose of at least 126 mg/dL. Insulin resistance was determined using the homeostasis model assessment estimate of insulin resistance. In a representative sample of the adult Korean population, MS was more prevalent in the highest quartile compared with the lowest quartile of serum ferritin concentrations in women following adjustments for age, education, smoking, alcohol intake, body mass index, aspartate aminotransferase, and alanine aminotransferase. Diabetes mellitus was more prevalent in the highest quartile compared with the lowest quartile of serum ferritin concentrations in premenopausal women and men. The geometric means of fasting insulin and insulin resistance determined using the homeostasis model assessment of insulin resistance in the fourth serum ferritin quartiles of postmenopausal women and men were significantly higher compared with those in the first quartile of the respective groups. The present study demonstrates that elevated serum ferritin concentrations are associated with an increased risk of MS and diabetes mellitus in a representative sample of the adult South Korean population. A v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m Metabolism w w w . m e t a b o l i s m j o u r n a l . c o m
Metabolic Syndrome and Related Disorders, 2015
Background: In some reports, serum ferritin (SF) has been associated with insulin resistance and metabolic syndrome. Methods: We studied non-Hispanic whites without diabetes mellitus in a postscreening examination. Participants included cases [HFE C282Y homozygosity; and transferrin saturation (TS) > 50% and SF > 300 mg/L (males) and TS > 45% and SF > 200 mg/dL (females), regardless of HFE genotype] and controls [HFE wildtype (wt/wt) and TS/SF 25th-75th percentiles]. We excluded participants with overnight fasts < 8 hr, cirrhosis, hepatitis B or C, pregnancy, or missing data. Observations were age, sex, C282Y homozygosity, body mass index (BMI), systolic and diastolic blood pressures (SBP, DBP), lymphocytes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), TS, SF, and glucose/insulin. Insulin resistance was defined as homeostasis model assessment of insulin resistance (HOMA-IR) 4th quartile (‡ 2.70). Results: A total of 407 women and 362 men (mean age 54 years) included 188 C282Y homozygotes and 371 wt/wt. Significant trends across HOMA-IR quartiles included age, male sex, BMI, SBP, DBP, lymphocytes, ALT, CRP > 0.5 mg/dL (positive), and TS (negative). Multiple regression on HOMA-IR revealed significant associations with male sex, BMI, SBP, lymphocytes, ALT, CRP > 0.5 mg/dL (positive), and DBP and SF (negative). Logistic regression on HOMA-IR 4th quartile revealed significant positive associations with age, male sex, BMI, and lymphocytes. Metabolic syndrome occurred in 53 participants (6.9%). Logistic regression on metabolic syndrome revealed these odds ratios: HOMA-IR 4th quartile [9.1 (4.8, 17.3)] and CRP > 0.5 mg/ dL [2.9 (1.6, 5.4)]. Conclusions: Age, male sex, BMI, and lymphocytes were positively associated with HOMA-IR after correction for other factors. HOMA-IR 4th quartile and CRP > 0.5 mg/dL predicted metabolic syndrome.
Serum ferritin and risk of the metabolic syndrome in some Korean rural residents
2008
OBJECTIVE-We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS-We conducted a cross-sectional study of 6,044 adults Ͼ20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS-After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 g/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P ϭ 0.002), postmenopausal women (47.5 vs. 28.2%, P Ͻ 0.001), and men (27.3 vs. 13.8%, P Ͻ 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS-Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.