Lupus erythematosus Graft-versus-Host Model of Systemic Nephritis in the Chronic Instrumental in the Pathogenesis of TWEAK/Fn14 Interactions Are (original) (raw)

This research investigates the role of TWEAK/Fn14 interactions in renal damage within a chronic graft-versus-host model of systemic lupus erythematosus (SLE). Results demonstrate that the absence of Fn14 significantly mitigates kidney injury, evidenced by reduced proteinuria, inflammatory cytokine levels, and macrophage infiltration. Treatment with an anti-TWEAK monoclonal antibody further supports the potential of targeting TWEAK as a novel therapeutic strategy to diminish renal damage in SLE, without compromising the adaptive immune response.