Should we use the shorter Thai-version quality of life and symptoms questionnaires in women with overactive bladder? (original) (raw)
Related papers
Neurourology and Urodynamics, 2005
Aims: This study examined test-retest reliability of four patient-reported outcome measures for patients with overactive bladder (OAB): Overactive Bladder Questionnaire (OAB-q), Patient Perception of Bladder Condition (PPBC), Urgency Questionnaire (UQ), and Primary OAB Symptom Questionnaire (POSQ). Methods: Patients recruited from urology clinics were scheduled for two visits 2 weeks apart and completed all questionnaires at both visits. A demographic form was completed at Visit 1; and a treatment e¡ect scale was completed at Visit 2. Test-retest reliability was examined among stable patients using intraclass correlations (ICC), Spearman's correlations, paired t-tests, Feldt's statistic, and kappas. Results: A total of 47 patients enrolled (mean age ¼ 66.0 years, 74.5% female), with 46 completing both visits; 35 were classi¢ed stable. Statistically signi¢cant correlations were present between Visits 1 and 2 (P < 0.05) for all subscales of the OAB-q, UQ, and POSQ. Subscale ICCs were moderate to high (OAB-q ! 0.83, UQ ! 0.46, POSQ continuous items ! 0.68). No signi¢cant di¡erences between Visit 1 and 2 were noted, except for the OAB-q symptom bother scale (change of 5.8 points on a 100-point scale). The multi-item subscales of the OAB-q and the UQ demonstrated good internal consistency (Cronbach's alpha ! 0.83 for all subscales) across both visits. Test-retest reliability of the PPBC was somewhat weaker than the other three measures, but still acceptable for use as a global, single-item outcome measure. Conclusions: The OAB-q, POSQ, and UQ demonstrated good test-retest reliability, with ICCs roughly equivalent or superior to those previously reported for 7-day micturition diaries. Findings suggest that the four measures examined in this study demonstrate the necessary reproducibility for use as outcome measures for OAB treatments.
The responsiveness of the OAB-q among OAB patient subgroups
Neurourology and Urodynamics, 2007
Aims: Although the majority of patients with overactive bladder (OAB) are continent, most patient-reported outcome measures for OAB were designed for patients with urinary incontinence. The overactive bladder questionnaire (OAB-q) was developed to assess symptom bother and HRQL among both continent and incontinent OAB patients; however, the responsiveness of the OAB-q among continent patients has not been evaluated. The purpose of this analysis was to assess the responsiveness of the OAB-q among OAB patient subgroups with a focus on continent patients. Methods: Post-hoc analyses were conducted from two 12-week trials of tolterodine for the treatment of OAB. Patients completed the OAB-q and daily bladder diaries (assessing frequency, urgency, and incontinence episodes) at baseline, 4 weeks, and 12 weeks. Three patient subgroups were identi¢ed on the basis of continence status at all three timepoints: (1) continent; (2) incontinent; and (3) incontinent at baseline and continent by Week 12 (ITC). General linear models were used to compare changes from baseline, and Spearman correlations assessed the association between OAB-q changes and bladder diary changes. E¡ect sizes were computed separately for each group. Results: A total of 262 continent, 552 incontinent, and 397 ITC patients were included in this analysis. Continent patients tended to be younger than incontinent patients, and patients were predominantly female, although continent patients had the highest percentage of male patients in both studies. Compared with continent patients, patients who were incontinent at baseline tended to have greater symptom bother and lower HRQL at baseline. All OAB-q change scores were consistently greatest for the ITC group (12.1^33.9), and greater for continent patients (10.8^28.6) than for incontinent patients (7.6^20.1). All three groups of patients experienced reductions in frequency and urgency episodes, and these changes were signi¢cantly correlated with changes in the OAB-q scales. Among all three groups, e¡ect sizes were in the moderate-to-large range for all OAB-q subscales except Social Interaction. Conclusions: The OAB-q is highly responsive to change between continent and incontinent patients with OAB, and is a valid tool for measuring treatment outcomes among continent OAB patients. Neurourol. Urodynam. 26: 196^203, 2007. ß 2006
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2005
To develop and test the reliability of a Thai version of the King's Health Questionnaire (KHQ). Three Thai Urologists forward translated the original English KHQ into a Thai version. Back translations were performed by an independent group of physicians. A consensus was reached on a final Thai version after comparing the original KHQ and various translations. Fifty Thai female patients with symptoms of overactive bladder were tested and retested every two weeks using the Thai version (twice) as well as the English version (once) of the KHQ. Test-retest reliability of the Thai questionnaire was measured using the kappa statistic. The Thai version of the KHQ was found to be reasonably reliable for use in Thai female patients with over active bladder symptoms.
The responsiveness of the Overactive Bladder Questionnaire (OAB-q)
Quality of Life Research, 2005
Purpose: The purpose of this study was to examine the responsiveness of the Overactive Bladder questionnaire (OAB-q) during anti-muscarinic treatment. Methods: OAB patients were treated with tolterodine ER 4 mg/day for 12 weeks. The OAB-q and 3-day micturition diaries were collected at baseline, 4, and 12 weeks. The patients' and physicians' perceptions of treatment benefit were assessed at 4 and 12 weeks. Responsiveness of the OAB-q was examined with effect sizes and comparisons to other measures using ANOVAs, t-tests, and correlations. Results: A total of 865 patients completed the 12-week study (mean age 61 years; 73% female; 89% Caucasian). From baseline to 4 weeks, significant improvements (p < 0.0001) occurred in all OAB-q subscales, which were maintained through week 12. The OAB-q was highly responsive with subscale effect sizes ranging from 0.44 (social interaction) to 1.2 (symptom bother). Significant score changes in all OAB-q subscales (p < 0.05) were associated with reductions of P3 urgency episodes, P3 micturitions, or P1 incontinence episode per day. Improvements in OAB-q scales were associated with changes in patient and physician perceptions of treatment benefit. Conclusions: The OAB-q was highly responsive and demonstrated responsiveness to reductions in urinary urgency, frequency, and incontinence during antimuscarinic treatment of OAB. The OAB-q appears to be a useful outcome measure for treatments of OAB.
The psychometric validation of a 1-week recall period for the OAB-q
International Urogynecology Journal, 2011
Introduction and hypothesis As shorter recall periods are sometimes preferable to longer recall periods, the objective of this study was to evaluate the psychometric characteristics and measurement properties of the 1-week recall version of the Overactive Bladder Questionnaire (OAB-q). Methods Secondary analyses were performed on data for three 12-week clinical trials of fesoterodine. Patients completed the Patient Perception of Bladder Condition (PPBC), the Patient Perception of Urgency Scale (PPUS), and 3-day bladder diaries in addition to the OAB-q at baseline, 4 and 12 weeks. Analyses were conducted to evaluate the reliability, concurrent and discriminant validity and responsiveness of the OAB-q 1-week recall version. Results The patients in the three studies (Study 1: N=516, Study 2: N=441; Study 3: N=882) had a mean age of 59.6, 59.4, and 59.9 years, respectively; and most of the patients were female (77.1%, 88.9%, and 82.9%) and White (76.6%, 90.0%, and 88.0%). Patients had been diagnosed with OAB for a mean of 5.2, 8.3, and 9.1 years, respectively. Cronbach's alpha values were greater than 0.85 across all samples and subscales. Correlations between the 1-week recall version of the OAB-q and the PPBC, PPUS, and most of the bladder diary variables were moderate to strong. Discriminant validity of the OAB-q was good, with significant differences in mean OAB-q scores across all response categories of the PPUS. The OAB-q was highly responsive to changes in patients' conditions as indicated by moderate to large effect sizes. The OAB-q 1-week recall version has a similar factor structure to the 4-week recall version with each subscale model demonstrating acceptable fit. Conclusion The 1-week recall version of the OAB-q appears to be reliable, valid, and responsive and is psychometrically equivalent to the 4-week recall version. The validation of the 1-week recall version offers researchers and clinicians an additional option for using the OAB-q.
Value in Health, 2010
To develop a mapping algorithm to transform the Overactive Bladder questionnaire-Short Form (OABq-SF) questionnaire responses into EQ-5D derived utilities in patients with OAB in Spain. METHODS: The culturally adapted Spanish versions of OABq-SF and EQ-5D questionnaires were self-administered on two occasions 3 months apart to a set of patients of both genders, above 18 years, diagnosed of OAB according with standard criteria and a score > 8 in the OAB-V8 scale and able to understand PRO instruments written in Spanish. Patients were recruited consecutively in clinics of Urology all over the country. Linear correlations between symptoms severity and health-related quality-of-life (HRQoL) domains of the OABq-SF and EQ-5D (VAS and TTO-tariffs) were computed. a combined score of both domains of OABq-SF was used to obtain a unique scoring per patient, although mapping was developed for both combined and separated punctuations of the OABq-SF using regression modelling. RESULTS: A total of 199 OAB patients (58.4 years, 74% women, 99% Caucasian, 37% workers and 36% primary schooling) from 18 urological clinics were evaluated. Utility values ranged from 1 to 0.01; mean value = 0.7623 (SD = 0.2292) and median = 0.79. Correlations with EQ-5D were −0.282 and −0.301 for the severity of symptoms domain at baseline an after 3 months of a medical intervention, and 0.329 and 0.369 for the HRQoL domain, respectively. Pearson coeffi cients for combined scoring were −0.331 and −0.351, respectively. All coeffi cients were signifi cant at P < 0.001 level. Observed relation between utilities and combined score followed a linear although heterocedastic pattern. Utilities distribution was clearly positively skewed with benign utilities prevailing. CONCLUSIONS: Utilities values for Spanish patients with OAB were mostly mild to moderate in the 0-1 range. a utility map was obtained for different levels of scoring in the OABq-SF questionnaire, which is useful to derive Qualityadjusted Life-year gain in economic evaluations.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2003
Overactive bladder (OAB) has substantial impact on health-related quality of life (HRQoL). The purpose of this research was to evaluate the psychometric properties of the King's Health Questionnaire (KHQ). The KHQ (n = 1284) was administered at baseline and 12 weeks post-treatment in a multinational, double-blind, randomized clinical trial of tolterodine for treatment of OAB. Country-specific psychometric analyses of HRQoL instruments were performed. Countries demonstrating marginal psychometric properties on the KHQ were pooled with same-language countries, re-evaluated, and aggregate analysis performed on the pooled data. Internal consistency of the KHQ was high, item characteristics were good, most assumptions of summed scales were met, and it is externally valid and consistent. Few problems with the KHQ were noted although the performance of the personal relationships domain was complicated by the 'not applicable' response category. Psychometric testing supports the ...
Value in Health, 2010
To develop a mapping algorithm to transform the Overactive Bladder questionnaire-Short Form (OABq-SF) questionnaire responses into EQ-5D derived utilities in patients with OAB in Spain. METHODS: The culturally adapted Spanish versions of OABq-SF and EQ-5D questionnaires were self-administered on two occasions 3 months apart to a set of patients of both genders, above 18 years, diagnosed of OAB according with standard criteria and a score > 8 in the OAB-V8 scale and able to understand PRO instruments written in Spanish. Patients were recruited consecutively in clinics of Urology all over the country. Linear correlations between symptoms severity and health-related quality-of-life (HRQoL) domains of the OABq-SF and EQ-5D (VAS and TTO-tariffs) were computed. a combined score of both domains of OABq-SF was used to obtain a unique scoring per patient, although mapping was developed for both combined and separated punctuations of the OABq-SF using regression modelling. RESULTS: A total of 199 OAB patients (58.4 years, 74% women, 99% Caucasian, 37% workers and 36% primary schooling) from 18 urological clinics were evaluated. Utility values ranged from 1 to 0.01; mean value = 0.7623 (SD = 0.2292) and median = 0.79. Correlations with EQ-5D were −0.282 and −0.301 for the severity of symptoms domain at baseline an after 3 months of a medical intervention, and 0.329 and 0.369 for the HRQoL domain, respectively. Pearson coeffi cients for combined scoring were −0.331 and −0.351, respectively. All coeffi cients were signifi cant at P < 0.001 level. Observed relation between utilities and combined score followed a linear although heterocedastic pattern. Utilities distribution was clearly positively skewed with benign utilities prevailing. CONCLUSIONS: Utilities values for Spanish patients with OAB were mostly mild to moderate in the 0-1 range. a utility map was obtained for different levels of scoring in the OABq-SF questionnaire, which is useful to derive Qualityadjusted Life-year gain in economic evaluations.
Neurourology and Urodynamics, 2004
Aims: The purpose of this study is to evaluate the psychometric properties of the Japanese version of the King's Health Questionnaire (KHQ) in patients with symptoms of overactive bladder (OAB) with urge incontinence. Methods: Data from a 12-week, randomized, double-blind, placebo-controlled clinical trial comparing tolterodine with oxybutynin in patients with symptoms of OAB in Japan were analyzed. Cronbach's alpha coe⁄cient was calculated as a reliability index. Inter-domain correlation was calculated for convergent and discriminant validity assessment. A factor analysis was conducted to explore the underlying factor structure of the KHQ. Sensitivity to clinical change was also evaluated. Results: The psychometric properties and clinical validity of the KHQ Japanese version were con¢rmed in this study population, and were similar between males and females. The KHQ's good reliability was evidenced by Cronbach's alpha coe⁄cients of >0.60, indicating reasonable consistency except for the personal relationship domain in males (0.47) and severity (coping) measure domain in females (0.59). Discriminant, convergent, and construct validity of the KHQ were also good, with the factor analysis identifying those factors which the KHQ was intended to measure. Finally, KHQ domains were generally responsive to clinical e⁄cacy variables; the KHQ also showed statistically signi¢cant sensitivity to change in patients' perception of bladder condition in all domains, except General Health Perception. Conclusions: Our analyses con¢rm psychometric properties and clinical validity of the KHQ Japanese version, which appears to o¡er a valid and reliable HRQoL instrument for use in clinical trials of antimuscarinics in Japan.