Electrical Membrane Properties in the Model Leishmania-Macrophage (original) (raw)

The study explores the electrical membrane properties of Leishmania within macrophages, highlighting the role of intracellular membranes in Leishmania survival. Emphasizing the effects of osmolarity and ionic concentration on Leishmania's ability to control membrane potential and nutrient transport, the research employs patch clamp techniques to analyze currents in infected J774.A1 macrophage-like cells. The findings indicate that alterations in electrical properties of macrophage membranes may influence the immune response against Leishmania, providing insights for potential therapeutic strategies.