Characterization and in Vitro Release of Chlorhexidine Digluconate Contained in Type I Collagen Porous Matrices (original) (raw)
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Revue Roumaine de Chimie
Three series of drug delivery systems consisting of type I collagen hydrogel containing 0, 0.02, 0.05 and 0.10% chlorhexidine digluconate (CHXD) and having pHs 3.8 and 7.4, the last noncrosslinked and crosslinked with 0.15% glutaraldehyde (GA), were prepared to be used for wound healing. FT-IR spectra show no effect of CHXD on triple helical conformation of collagen irrespective of pH and crosslinking. CD spectra also indicate the absence of CHXD and GA effect on collagen conformation. Rhoogram show pseudoplastic behaviour for all the hydrogels and a decrease of viscosity at zero shear rate with increasing CHXD concentration, regardless of pH and crosslinking, due to its binding to collagen and GA. Dynamic rheological measurements reveal the prevalence of elastic component of viscoelasticity in all the hydrogels and the insignificant effect of CHXD on viscosity in acid medium. CHXD reduces the elastic component in slight basic medium, while GA increases it significantly both in the ...
Collagen Hydrogels Containing Chlorhexidine Digluconate: Characterization and in Vitro Drug Release
2017
Collagen is able to heal wounds but, being a protein, it serves as a substrate for bacteria and can not promote it. Associated with antibiotics/antiseptics and applied topically, it becomes a local drug delivery system for wound infection control. Three series of collagen hydrogels with pHs 3.8 and 7.4 containing 0, 0.02, 0.05 and 0.10% chlorhexidine digluconate (CHD), w/w, the last without or with 0.15% glutaraldehyde (GA), w/w dry collagen, were prepared. Checking of triple helical structure of collagen molecules was performed by FT-IR and CD. FT-IR spectra show no effect of CHD on triple helical conformation irrespective of pH and crosslinking. The same is shown by CD spectra. Rheograms show pseudoplastic behaviour for all the hydrogels and a decrease of viscosity at zero shear rate with increasing CHD concentration, regardless of pH and cross-linking due to its binding to collagen and GA. Dynamic rheological measurements reveal the prevailing of elasticity in all the hydrogels, ...
American Journal of PharmTech Research
Hydrogel product constitute a group of polymeric material, the hydrophilic structure of which render them capable of holding large amount of water in their three dimensional networks. Due to their high water content, porosity and soft consistency, they closely simulate natural living tissue, more so than any other class of synthetic biomaterials. Furthermore, hydrogels can be formulated in a variety of physical forms, including slabs, microparticles, nanoparticles, coatings, and films. As a result, hydrogels are commonly used in clinical practice and medicine for a wide range of applications, including Tissue engineering and Regenerative medicine, Diagnostics, Cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This biomaterial can hold large amount of biological fluids and swell. When swell, they are soft and rubbery and resemble the living tissue exhibiting excellent biocompatibility. The prime objective of this article is to concern the classification of hydrogel on different bases, properties of hydrogel and its method of preparation and physical and chemical characteristics of these products.
P HYSICOCHEMICAL F OUNDATIONS AND S TRUCTURAL D ESIGN OF H YDROGELS IN M EDICINE AND B IOLOGY
Annual Review of Biomedical Engineering, 2000
Key Words controlled release, diffusion, polymer network, responsive hydrogels, swelling s Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels.
Hydrogels and their medical applications
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1999
Biomaterials play a key role in most approaches for engineering tissues as substitutes for functional replacement, for components of devices related to therapy and diagnosis, for drug delivery systems and supportive scaolds for guided tissue growth. Modern biomaterials could be composed of various components, e.g. metals, ceramics, natural tissues, polymers. In this last group, the hydrogels, hydrophilic polymeric gels with requested biocompatibility and designed interaction with living surrounding seem to be one of the most promising group of biomaterials. Especially, if they are formed by means of ionizing radiation. In early 1950s, the pioneers of the radiation chemistry of polymers began some experiments with radiation crosslinking of hydrophilic polymers. However, hydrogels were analyzed mainly from the point of view of the phenomenon associated with radiation synthesis, with topology of network and relation between radiation parameters of the processes. Fundamental monographs on radiation polymer physics and chemistry written by A. Charlesby (Atomic Radition and polymers, Pergamon Press, Oxford, 1960) and A. Chapiro (Radiation Chemistry of Polymeric Systems, Interscience, New York, 1962) proceed from this time. The noticeable interest in the application of radiation techniques to obtain hydrogels for biomedical purposes began in the late sixties as a result of the papers and patents invented by Japanese and American scientists, headed by Kaetsu in Japan and Homan in USA. Immobilization of biologically active species in hydrogel matrices, their use as drug delivery systems and enzyme traps as well as the modi®cation of material surfaces to improve biocompatibility and their ability to bond antigens and antibodies had been the main subjects of these investigations. In this article a brief summary of investigations on mechanism and kinetics of radiation formation of hydrogels as well as some examples of commercialized hydrogel biomaterials have been presented.
Acta Scientific Pharmaceutical Sciences, 2021
36. Li J. "Self-assembled supramolecular hydrogels based on polymer-cyclodextrin inclusion complexes for drug delivery". NPG Asian Material 2 (2010): 112. 37. Moncada-Basualto M. "Supramolecular hydrogels of β-cyclodextrin linked to calcium homopoly-lguluronate for release of coumarins with trypanocidal activity". Carbohydrate