Thyroid Function in Children with Nephrotic Syndrome and Normal Renal Function in a Tertiary Level Hospital, Rajshahi (original) (raw)
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Thyroid Function in Children with Idiopathic Nephrotic Syndrome
Chattagram Maa-O-Shishu Hospital Medical College Journal, 2020
Background: The underlying abnormality in nephrotic syndrome is an increase inpermeability of the glomerular membrane. Urinary loses of binding proteins such asThyroxine Binding Globulin (TBG) albumin results in a reduction in serumthyroxine(T4) and sometimes in total T3 levels. The study was done to assess thyroidhormone status of idiopathic nephrotic syndrome patients at diagnosis, comparethe thyroid function after treatment with steroid, correlate with serum albumin andcompare the thyroid function with control group. Materials and methods: It was an analytic type of cross sectional study, done inPaediatric ward, Chittagong Medical College Hospital, Chattogram from 01.05.11 to30.11.11. Total 58 patients in two groups were included. In group A 32 cases ofidiopathic nephrotic syndrome patients and in group B 26 control cases of same ageand sex were taken. In group A thyroid function was done at initial diagnosis and inhypothyroid patients in this group again thyroid function was don...
Sultan Qaboos University Medical Journal [SQUMJ]
Objectives: Nephrotic syndrome is a glomerular disease characterised by a loss of albumin and high-molecular-weight proteins such as thyroxine-binding globulin and thyroid hormones, potentially resulting in subclinical or even overt hypothyroidism. This study aimed to compare thyroid hormone levels between nephrotic children and healthy controls as well as between nephrotic children in the active phase of the disease and those in remission. Methods: This case-control study was conducted between March 2016 and 2018 at a paediatric hospital in Qazvin, Iran. A total of 73 nephrotic children comprised the case group—including 49 with active disease and 24 in remission—while the control group included 74 healthy children. Thyroid function was assessed according to levels of thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), total T4, total T3 and anti-thyroid peroxidase. Results: All of the controls had normal total T4 levels. Elevated TSH levels were mor...
Thyroid Function in Childhood Nephrotic Syndrome
2019
Original Research Article Children with Nephrotic syndrome while in nephrosis commonly have a state of mild or subclinical hypothyroidism although they are clinically euthyroid. Loss of thyroxine (T4) and thyroxine binding Globulin (TBG) leads to decrease in total T4 and increase in TSH.A prospective observational study was conducted in children with Nephrotic syndrome over a period of 18 months from January 2013 to June 2014. Objective: To compare the thyroid function of Nephrotic children during nephrosis with that in remission and with healthy controls. Methods: 40 Nephrotic Children between 3-12 years of age in initial episode or in relapse were enrolled in this study. Their thyroid function (Serum FT4, TSH and Thyroglobulin) during nephrosis and while in remission was compared with age-matched healthy controls. Results: Mean age of study population was 83.8 +/_34.21months compared to 83.18 +/_36.6months in controls. Male: Female ratio was 1.8:1. Mean value of serum FT4 in child...
Evaluation of thyroid dysfunction in patients with nephrotic syndrome
Medicine and Pharmacy Reports
Background. Thyroid and kidney are interdependent on each other in many ways for optimal functioning of either organs. Proteinuria causes urinary loss of thyroid hormones and thyroid binding globulins in substantial amount resulting in subclinical/overt hypothyroidism. Autoimmunity, which can attack both the organs simultaneously, may also contribute considerably to the abnormal functioning of both organs. Aims and objectives. To study the effect of proteinuria on the thyroid function and its association with autoimmunity. Methods. The study was carried out on a total number of 60 patients with nephrotic range proteinuria attending the kidney and dialysis clinic PGIMS, Rohtak, India. Thyroid profile and baseline investigations along with Anti-TPO antibodies and renal biopsy were carried out on each patient. Patients were allocated to 2 groups based on Anti TPO antibody results: group A comprising 25 Anti-TPO Ab positive patients and group B comprising 35 Anti-TPO Ab negative patient...
Paediatrica Indonesiana, 2020
Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0....
Thyroid Dysfunction In Patient With Nephrotic Syndrome
TAJ: Journal of Teachers Association, 2018
A large amount of protein is lost in urine along with thyroid hormones and hormone binding proteins in nephrotic syndrome (NS). This hormone loss may lead to low T4, T3 and sometimes high TSH level and often to be associated with subclinical or overt hypothyroidism. This study was done to assess thyroid dysfunction in patients with NS and to correlate thyroid hormones with albumin level of those subjects. Forty diagnosed patients of idiopathic NS and same number of age matched healthy control were selected in this study. Thyroid status was evaluated in all the subjects. In patients with NS mean (± SD) of T4, T3 and TSH were 39.34 (±29.49), 1.05 (±0.83) and 11.34 (±18.15) respectively. Mean (±SD) of T4, T3 and TSH in healthy control were 83.34 (±27.23), 2.04 (±0.70) and 2.73 (±1.79) respectively. Mean serum total T4 and T3 of patients with NS were found to be significantly lower (t=-6.935, df= 78, p<0.001 and t =-5.750, df = 78, p<0.001 respectively) and mean TSH was found to be significantly higher (t= 2.984, df = 78, p<0.01) in patients with NS as compared to healthy control. Sub clinical hypothyroidism was observed in 20 (50%) and overt hypothyroidism in 4 (10%) of patients. Significant positive correlation was found between serum albumin and serum total T4 (r = 0.818, p <0.001) and also with total T3 level (r = 0.903, p <0.001). But no correlation was found between serum albumin and serum TSH (r =-0. 292, p>0.05) in patients with NS. So, nephrotic range proteinuria may be associated with loss of thyroid hormone in urine and can lead to subclinical or even overt hypothyroidism.
Pediatric Nephrotic Syndrome; Clinical Characteristics and Nutritional Status
Al-Mukhtar Journal of Sciences, 2020
Nephrotic syndrome (NS), is the most common chronic renal disorder in children, with multifactorial risk factors and complex etiology. Therefore, the aim of the present study was to determine the age and gender distribution and also determine the clinical characteristics and nutritional status of pediatric nephrotic syndrome. A total of 75 patients with nephrotic syndrome series were selected through semi-constructed questionnaires. The age of our subjects ranged between 1-18 years. Body weight and height were extracted from patient files or self-reported to calculate BMI percentile. Laboratory tests such as blood glucose, lipid profile vitamin D, and HbA1C were included. All samples were analyzed through either mean ±SEM or Chi-square for determining significant differences. The present study showed that 75 patients were diagnosed as nephrotic syndrome. The average age of patients was 9 years old and the age which showed significance was 6-10 years (p=0.04). In comparison to female...
Birat Journal of Health Sciences
Introduction: Nephrotic syndrome is an important chronic disorder in children and it’s one of the important diagnostic criteria is presence of heavy proteinuria (> 40 mg/m2/hour). As 24-hour urinary protein estimation is cumbersome, inconvenient, time consuming and expensive, a more convenient and accurate method of urinary protein estimation is needed. 24-hour urinary protein estimation and urine protein/creatinine in a child with nephrotic syndrome correlates well but there are very few studies done in Nepal to prove this correlation. Hence, this study is undertaken with objective of evaluating usefulness of urine protein/creatinine (UP/UC) in random sample of urine as a rapid and reliable test for quantification of proteinuria and to know their correlation with 24hour urinary protein excretion. Objectives: Primary Objective: To evaluate accuracy of urine protein creatinine ratio (UP/UC) in early morning sample in comparison with 24 hours urinary protein excretion in children o...
A Review on Nephrotic Syndrome in Children
Der Pharmacia Lettre, 2021
Context: Nephrotic syndrome is a common pediatric kidney disease which is characterized by the leakage of the protein from the blood into urine through the damaged glomeruli. Nephrotic syndrome is characterized by heavy proteinuria, hypoalbunemia (serum albumin <2.5g/dl), hyperlipidemia (serum cholesterol >200mg/dl) and edema. Nephrotic range proteinuria is present if early morning urine protein is 3+/4+ (on dipstick test), spot protein/creatinine ratio >2mg/mg or >200mg/mmol urine albumin excretion >40 mg/m2 per hour. Precise quantitative measurement is necessary by 24 hour urine protein measurement.
2018
Nephrotic syndrome, or nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. While nephrotic-range proteinuria in adults is characterized by protein excretion of 3.5 g or more per day but in children it is defined as protein excretion of more than 40 mg/m2/h or a first-morning urine protein/ creatinine of 2-3 mg/mg creatinine or greater. Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, is very prevalent in children with nephrotic syndrome. The aim of this study was to evaluate the association between serum Prednisolone and serum albumin in childhood nephrotic syndrome. This prospective interventional study was done in the department of paediatric nephrology & kidney diseases, Dhaka Shishu (Children) Hospital, Sher E Bangla Nagar, Dhaka and Clinical Pharmacy & Pharmacology Dept. University of Dhaka from January 2013 to December 2013. Se...