Prevalence and characteristics of dysfunction of right ventricle in peripartum cardiomyopathy (original) (raw)
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Circulation: Heart Failure, 2016
Background— Peripartum cardiomyopathy has variable disease progression and left ventricular (LV) recovery. We hypothesized that baseline right ventricular (RV) size and function are associated with LV recovery and outcome. Methods and Results— Investigations of Pregnancy-Associated Cardiomyopathy was a prospective 30-center study of 100 peripartum cardiomyopathy women with LV ejection fraction (LVEF) <45% within 13 weeks after delivery. Baseline RV function was assessed by echocardiographic end-diastolic area, end-systolic area, fractional area change, tricuspid annular plane excursion, and RV speckle-tracking longitudinal strain. LV recovery was defined as LVEF of ≥50% at 1 year, persistent severe LV dysfunction as LVEF of ≤35%, and major events as death, transplant, or LV assist device implantation. RV measurements were feasible for 90 of the 96 patients (94%) with echocardiograms available. Mean baseline LVEF was 36±9%. RV fractional area change was <35% in 38% of patients....
Right ventricular systolic function in peripartum and dilated cardiomyopathies
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011
Right ventricular (RV) systolic function of peripartum cardiomyopathy (PPCM) has not previously been well described and compared with that of dilated cardiomyopathy (DCM). The aim of the present study was therefore to assess and compare RV systolic function between PPCM and idiopathic DCM, using tricuspid annular plane systolic excursion (TAPSE). The study was cross sectional in design, carried out among adults referred for echocardiography to three laboratories in the City of Kano, Nigeria. Patients were recruited serially from October 2008 to May 2009. DCM and PPCM were defined according to the 2007 recommendations of the European Society of Cardiology working group on myocardial and pericardial diseases. Reduced TAPSE, signifying RV systolic dysfunction, was defined as value of ≤14 mm. A total of 90 patients were recruited over the 8 months period. Mean TAPSE was significantly less in PPCM (12.58 ± 4.27 mm) as compared with DCM patients (14.46 ± 3.21 mm) (P= 0.028; significant), ...
JACC. Cardiovascular imaging, 2017
This study sought to determine the prevalence, correlates, and impact on cardiac mortality of right ventricular (RV) dysfunction in nonischemic cardiomyopathy. Current heart failure guidelines place little emphasis on RV assessment due to limited available data on determinants of RV function, mechanisms leading to its failure, and relation to outcomes. We prospectively studied 423 patients with cardiac magnetic resonance (CMR). The pre-specified study endpoint was cardiac mortality. In 100 patients, right heart catheterization was performed as clinically indicated. During a median follow-up time of 6.2 years (interquartile range: 2.9 to 7.6 years), 101 patients (24%) died of cardiac causes. CMR right ventricular ejection fraction (RVEF) was a strong independent predictor of cardiac mortality after adjustment for age, heart failure-functional class, blood pressure, heart rate, serum sodium, serum creatinine, myocardial scar, and left ventricular ejection fraction (LVEF). Patients wit...