Childhood Brucellosis in Eastern India (original) (raw)
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Background: Brucellosis is a widespread zoonotic infection. This disease is endemic in many parts of Asia, including India. Brucellosis is a major cause of pyrexia of unknown origin (PUO). Persons exposed to infected animals or contaminated animal products are at high risk. Seropositivity among animal handlers, veterinarians and dairy workers has been documented in India. Thus, the present study was aimed to determine prevalence of brucellosis among PUO cases and occupationally exposed individuals. Methods: In this study, serum samples (n=282) from cases of pyrexia of unknown origin (PUO) (n=243), and occupationally exposed individuals (n=39) were collected and tested for brucellosis by Rose Bengal plate test (RBPT), serum agglutination test (SAT), indirect ELISA, IgG and IgM ELISA. Blood culture for isolation of Brucella was performed for 10 serologically positive patients using BACTEC 9050 automated blood culture system. Biochemical tests and PCR techniques were used for confirmation of the isolates.
Clinical profile of brucellosis from a tertiary care center in southern India
Asian Pacific journal of tropical medicine, 2011
To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis. Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation. Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered s...
Human Brucellosis : Still an Unfamiliar and Misdiagnosed Disease in India
2015
Background: Human brucellosis is a disease with protean clinical manifestations. Despite many awareness programmes, it is still missed or wrongly diagnosed. This leads to chronic morbidity leading to misery and loss of working days. Aim and Objectives: To assess the microbiological, clinical and epidemiological aspects of human brucellosis. Materials and Methods: Patients with positive brucella screening test constituted the study material. A detailed laboratory, clinical, epidemiological study along with response to the treatment was analyzed. Results: Seroprevalence of brucellosis was found to be 1.75%. Brucellosis was clinically diagnosed in only 12.73% of cases. Fever, joint pain and low backache were the commonest symptoms. Close contact with animals and raw milk ingestion were the major sources of infection. Knowledge regarding brucellosis and its prevention was lacking in patients. Brucellosis was not considered as one of the differential diagnosis by the treating physicians....
Brucellosis Suspicion is the Most Important Criterion for Diagnosis Particularly in Endemic Regions
The Open Orthopaedics Journal, 2016
Introduction: Brucellosis is a zoonotic infectious disease that remains endemic in developing countries. The purpose of this study is to emphasize the need for considering brucellosis as a diagnosis, since this disease has a high risk of complications among young patients when not treated appropriately. Methodology: A total of 88 brucellosis cases with blood cultures that were positive for the pathogen were evaluated retrospectively in this study. Results: The patients included 33 males (37.5%) and 55 females (62.5%) with a median age of 8.9 years (range: 5-14 years). A total of 43.1% (n=38) of the cases included occupational exposure to animals as a possible infection source. The consumption of raw milk products, especially cheese, was present in 52.2% (n=46) of the cases. Clinically, 55 of the cases were acute (62.5%), 23 of the cases were subacute (26.2%) and 10 of the cases were chronic (11.3%). The distribution of the joint pain complaints was as follows: 62.5% (n=55) of patien...
Journal of Comprehensive Pediatrics, 2012
Background: Brucellosis, a multisystem infection that may imitate other conditions, shows a low incidence during childhood and may be misdiagnosed. Brucellosis has become a major medical problem in a number of the provinces in Iran. Objectives: To study the epidemiology, clinical and laboratory features, and management of brucellosis.
Seroepidemiology of Human Brucellosis in Karnataka
A seroprevalence study of brucellosis in humans was undertaken among high risk population of north Karnataka. A total of 201 serum samples were collected from various high risk group individuals and subjected to three different tests i.e., Rose Bengal plate test (RBPT), standard tube agglutination test (STAT) and 2 mercaptoethanol test (2-MET). On the analysis of 201 serum samples, 30 (14.92%) were positive to RBPT, 33 (16.41%) to STAT and 8 (3.98%) to 2-MET. The prevalence of brucellosis was found to be highest among individuals in the age group of >50 yrs and lowest in age group of <20 yrs. Sex wise prevalence of brucellosis was more prevalent among males compared to females.
Clinical manifestations and laboratory findings of 496 children with Brucellosis in Van, Turkey
Pediatrics International, 2015
Brucellosis is a zoonotic disease, which is associated with great economic and general health concerns. This is an endemic disease in Iran, and thus this study aimed to investigate its epidemiology and trend over a ten-year period in children hospitalized in northwest Iran Materials and Methods: A retrospective study was conducted on children hospitalized with brucellosis diagnosis in the Children's Hospital. Information of the patients, such as type of living place, age, history of consuming unpasteurized dairy products, family history of brucellosis in the past year, type of contact patterns with livestock, clinical symptoms, Wright's test, 2-mercaptoethanol test, Coombs Wright test and treatment failure, was collected Results: Over a ten-year period, 59 medical records were extracted, out of which 21 subjects (35.6%) were female and 38 (64.4%) male. The mean age of involvement was 80.5 months. In addition, 16.9% and 22% of patients had a history of contact with livestock, and 22% had a history of consuming unpasteurized dairy products. Moreover, 78.6% of patients had Wright's test titers of ≥1:160 and 91.8% had Coombs test titers of ≥1:160. Blood culture results of 19 patients were available, out of which 21.1% were culture-positive Conclusion: Epidemiological studies assessing important risk factors for the spread of brucellosis in different regions across the world are very effective in disease control. Moreover, the results revealed that the serological tests can be used to diagnose brucellosis. To the best of our knowledge, this is the first report about epidemiology of children brucellosis in northwest Iran
EPIDEMIOLOGY OF BRUCELLOSIS IN HIGH RISK GROUP & PUO PATIENTS OF WESTERN -RAJASTHAN
National Journal of Community Medicine, 2012
Background: Brucellosis is an important re-emerging zoonosis with a worldwide distribution. Brucellosis in India is yet a very common but often neglected disease. Methods: A retro prospective study was done in western Rajasthan on PUO patients those who attended Hospital attached of Dr. SNMC Jodhpur. Total 570 samples were tested for Brucella antibodies titration. In study group samples of PUO Patients (420), Milkmen & Veterinarians (70), Meat Handlers (30) & Healthy Control (50) were taken for finding their Antibrucella antibody titers Typhoid by Widal Test, Malaria by MP Strip Test were included in exclusion criteria for PUO patients All samples were tested by Stained Febrile Antigen. Results: Positivity for Antibrucella Antibody was 25.72%, 26.66%, 37.14%& 6.00% in PUO Patients, Meat Handlers & Veterinarians, Milkman & Healthy Control respectively. Conclusion & Recommendations: As climatic conditions of Western Rajasthan mimics with Middle East where Brucellosis is prevalent, in clinical practice Brucellosis should be kept in differential diagnosis & management of PUO& all preventive measure should be used for prevention of this Zoonotic disease. A safe and effective vaccine in human is not yet available. Prevention is dependent upon increasing public awareness through health education programmes and safe livestock practices. Active co-operation between health and veterinary services should be promoted.
An epidemiological study of brucellosis in rural area of North Karnataka
International Journal of Medical Science and Public Health, 2015
serious public health issue in many developing nations, and in high endemic regions such as Africa, the Mediterranean, the Middle East, parts of Asia, and Latin America. [1] It remains a grave concern to human health in India, in particular, to the rural population who are principally engaged in agriculture, including animal husbandry, thus are in close contact with domestic animals. Alarming increase in the transmission of brucellosis in rural areas owing to the high requirement for dairy products, together with modified and exaggerated farming practices and lack of awareness among the rural population, raises concern. [2,3] Epidemiological evidence reveals that, in India, brucellosis is recorded in almost all states but the scenario differs between states and is present in different species of mammalian farm animals including cattle, goats, buffalo, Background: Brucellosis is a significant important reemerging endemic zoonotic transmissible disease in India but often neglected. It still poses a noteworthy threat to human health in India, in particular, to the rural population who are principally engaged in agriculture, including animal husbandry, thus are in close contact with domestic animals. Objective: To study the seroprevalence of brucellosis among contacts of the cases in rural area of North Karnataka. Materials and Methods: A case contact-based epidemiological study was undertaken followed by identification of 190 close contacts at Kadoli village of Belagavi taluk and district. Serological screening test of provisionally diagnosed cases were done by Rose Bengal plate test (RBPT) and standard agglutination test (SAT); repeat SAT was done using 2-mercaptoethanal (2-ME) blocking agent. Data were expressed as percentages, and statistical analysis was done using c 2 test. Result: Of the total 190 contacts of the cases, 90 (47.4%) of them showed signs and symptoms suggestive of brucellosis and were screened by RBPT, which showed positivity in 42.2% of them. Seroprevalence of brucellosis using SAT with titer of 160 IU/mL or above was found to be 28.8% among clinical suspects. Conclusion: Our study demonstrated a high seroprevalence of brucellosis in the rural area, among the contacts who are often neglected or misdiagnosed. The risk of developing brucellosis was attributed to unsafe animal handling and consumption of unpasteurized milk. Apparently low incidence is an illusion, as many cases go unreported. A high level of suspicion is needed for early detection and the right treatment.