FAK Mediate Promigratory Actions of Basic Fibroblast Growth Factor in Astrocytes via CCL2 and COX2 (original) (raw)

Basic fibroblast growth factor (FGF2) plays a critical role in regulating astrocyte behavior, particularly in promoting migration. The study investigates the signaling pathways involved, specifically focusing on the roles of JNK, ERK, and FAK in mediating these actions. Findings indicate that FGF2 induces the secretion of CCL2 and activates COX2, suggesting an intricate network of molecular interactions crucial for astrocyte migration. Subsequent experiments highlight the immunomodulatory effects of FGF2 and the specific involvement of FGFR2 in these processes.