Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells (original) (raw)

Abstract

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Treatment of Th cells with compounds that elevate cAMP levels increases Th2-type lymphokine expression, particularly IL-5. This study shows that inhibiting protein kinase A (PKA) impairs IL-5 synthesis in Th2 cells, while enhancing PKA activity boosts IL-5 in Th0 cells. The results indicate that PKA activation in Th effector cells induces IL-5 gene expression through GATA-3, highlighting the collaboration between PKA and GATA-3 in regulating Th2 cytokine production.

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