Monocyte Migration and Inflammatory Response in the Pathogenesis of Rheumatoid Arthritis (original) (raw)

International Journal of Advanced Research

Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects multiple synovial joints. Monocytes/Macrophages accumulate in synovium, where they play a central role in inflammation and joint destruction. In human peripheral blood, two monocyte subpopulations with distinct functional properties have been defined by their expression of CD14 and CD16 molecules. In the present study, we investigated the relevance of CD14+, CD16+, MIF and TLR4 expression in blood monocytes in RA population. Flowcytometric analysis was done for different monocytes by staining with CD14, CD16, MIF and TLR4 tagged with flurochromes in order to assay the inflammatory cytokines from 257 RA patients and 270 healthy controls. Inflammatory monocytes (CD14+ and CD16+) population was significantly high in subjects with RA than the healthy control. mCD14, mTLR4, CD16 and MIF expression levels were also increased the susceptibility of RA. The study also found that expression level of TLR4, CD14,...