Anticancer Activity of Quinoline Derivatives; An Overview (original) (raw)

Quinoline, 1-aza naphthalene/benzo pyridine, is nitrogen containing heterocyclic nucleus which is one of the major building blocks of many synthetic drugs. Quinoline derivatives have attracted many scholars’ attention because of their wide range of pharmacological activities such as antimalarial, anticancer, anti-inflammatory, antimicrobial etc. There are so many quinoline derivatives with anticancer activities were reported in various renowned journals. In this review, an attempt is made to compile the latest updates on anticancer activity of quinoline derivatives. Quinoline derivatives plays an important role in anticancer drug development through different mechanism of action like topoisomerase I and II inhibition, proteasome inhibition, antimitotic and tubulin polymerization inhibition etc.