PLATELET-LYMPHOCYTE RATIO (PLR) MARKERS IN ACUTE CORONARY SYNDROME (Platelet Lymphocyte Ratio (PLR) sebagai Petanda Sindrom Koroner Akut) (original) (raw)
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Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018
Sindrom Koroner Akut (SKA) merupakan manifestasi akut dari plak aterosklerosis pembuluh darah koroner yang koyak atau pecah. Platelet berperan penting pada patogenesis aterosklerosis dan SKA. Nilai MPV yang tinggi mencerminkan ukuran platelet yang lebih besar dan lebih reaktif. Penelitian ini merupakan penelitian retrospektif potong lintang di Rumah Sakit Dr. Wahidin Sudirohusodo Makassar dengan mengambil data pasien dengan diagnosa SKA (STEMI, NSTEMI dan UAP). Sampel SKA kemudian dibagi menjadi kelompok Infark Miokard (STEMI dan NSTEMI) dan non-Infark Miokard (UAP). Nilai platelet dan MPV diambil dari hasil pemeriksaan darah rutin pertama sejak pasien masuk Instalasi Gawat Darurat RSUP Dr. Wahidin Sudirohusodo. Nilai platelet dan MPV dibandingkan berdasarkan kelompok SKA. Sebanyak 251 data pasien SKA Infark Miokard dan non-Infark Miokard diperoleh masing-masing 191 data pasien Infark Miokard dan 60 data pasien non-Infark Miokard. Hasil uji statistik Mann-Whitney tidak didapatkan pe...
Platelet indices in patients of acute coronary syndrome patients in tertiary care hospital
International journal of applied research, 2015
Acute coronary syndromes (ACS) encompass a spectrum of coronary artery disease, from unstable angina to transmural myocardial infarction. Despite the developments regarding its diagnosis and treatment in recent years, acute coronary syndromes (ACS) keep its place of the most important reason of morbidity and mortality. The frequency of ACS is increasing as the population ages, and therefore, knowledge of knowing who are at high risk is essential. Aim was to study Mean Platelet Volume and Platelet Count of acute coronary syndrome (STEMI, NSTEMI, Unstable Angina) patients. The present one year cross-sectional study was done in the Department of Medicine and Cardiology, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 400 patients of age more than 18 years who presented with Acute Coronary Syndromes were included in the study. Patients were subjected to clinical examination, necessary investigations including Complete Haemogram, platelet count, electroc...
Jurnal Analis Medika Biosains (JAMBS)
Selama penyimpanan, aktivitas metabolic dari trombosit dan residual leukosit berlanjut untuk mengkonsumsi nutrient dan menghasilkan produk metabolik yang berbahaya. Aktivasi faktor pembekuan, celular debris, dan enzim proteolitik ditemukan dalam plasma suspensi yang berefek kurang baik terhadap trombosit. Banyak perubahan structural pada sitoskeleton trombosit dan antigen di membrane permukaan selama penyimpanan dan berhubungan dengan buruknya recovery dan survival post transfusi in vivo. Tes in vitro yang digunakan untuk menilai perubahan pada trombosit umumnya hanya jumlah trombosit, volume konsentrat, pH selama 5 hari, dan leukosit. Komponen Trombosit harus disimpan pada Platelet Agitator dengan suhu penyimpanan 22oC ± 2oC. Penelitian ini dilaksanakan di UTD PMI Kota Surabaya. Untuk melihat efektifitas penyimpanan komponen Trombosit pada Platelet Agitator. Berdasarkan hasil uji mutu internal untuk produk TC di UTD PMI Kota Surabaya pada tahun 2019 dari 30 kantong darah. Penelitia...
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
Stroke is a sudden and acute focal or global cerebral functional disorder lasting more than 24 hours due to cerebral blood flow impairment. Platelets play an essential role in the pathophysiology of non-hemorrhagic stroke by causing thrombus formation in blood vessels after erosion or rupture of atherosclerotic plaques. Mean platelet volume, PDW and platelet counts are hematological parameters that can be measured on routine blood tests that can describe platelet function and activity and are standard tests carried out in hospitals. The aim of this study was to analyze the differences in MPV, PDW and platelet count between non-hemorrhagic strokes and hemorrhagic strokes. This was a retrospective cross-sectional study conducted in the Dr. Wahidin Sudirohusodo General Hospital of Makassar. A total of 375 Non-Hemorrhagic Stroke (NHS) and 221 Hemorrhagic Stroke(HS) patients were included in this study. Mean platelet volume, PDW and platelet counts were obtained from complete blood count at the time of admission. There was a significant difference in platelet count between NHS and HS patients (p=0.01). Never the less, there were no significant differences between MPV and PDW between NHS and HS patients (p=0.19 and p=0.54, respectively). The results of this study indicated that there were significant differences in platelet counts in HS and NHS with increased platelet counts being a risk factor for NHS and a decrease in platelet counts as a risk factor for HS. However, there were no significant differences in the values of MPV and PDW in NHS and HS patients. It is recommended to study using a better sample selection method so that it can eliminate the occurrence of bias with other diseases which can also cause a decrease and increase in MPV values, PDW and platelet counts.
Ankara Medical Journal, 2016
Objectives: We examined the association between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with the Canadian Cardiovascular Society (CCS) angina grade of patients in outpatient setting. Materials and Methods: The study population included patients with chest pain who had admitted to our outpatient clinic. The study group consisted of noncardiac chest pain and atypical angina (group 1), CCS class 1 and class 2 angina (group 2) and CCS class 3 and class 4 (group 3) patients. Results: The neutrophil lymphocyte ratio was positively correlated with extent of CAD and angina grade (p<0.001). To test the power of neutrophil lymphocyte ratio for distinguishing group 1 and group 2+3, and group 1+2 and group 3, ROC analysis was performed. The NLR had AUC values of 0.714 and 0.698 (p<0.001), which demonstrate its sufficiency to distinguish patients in group 1 from individuals in group 2+3 and patients in group 1+2 from individuals in group 3, respectively. The platelet lymphocyte ratio did not differ among groups (p>0.05). Conclusion: The NLR is a cheap and practical inflammatory marker and is associated with CCS angina grade of patients in outpatient setting.
Journal of Rawalpindi Medical College
To determine the frequency of raised Mean Platelet Volume (MPV) in patients with acute coronary syndrome (ACS) in HIT Hospital Taxila. Materials and Methods: A case-control study was at HIT Hospital Taxila. All the patients presented with chest pain who fulfilled the inclusion criteria were recruited into the study. Patients with acute coronary syndrome were included in the case group (ACS group). The patients included in the control group (non-ACS group) had chest pain without having ischemic heart disease or risk of ischemic heart disease. Data were analyzed using SPSS version 28. To find out the correlation between the type of chest pain and mean platelet volume chi-square test was applied. Results: Total 93 patients were included in this study. 51 patients were included in the ACS group while 42 were in non- ACS group. To find out the correlation between the type of chest pain and mean platelet volume chi-square test was applied. The results show a significant association betwee...
IOSR Journals , 2019
Background;-Platelet volume indices (PVI), andreference intervals (RIs) are associated in clinical practice with hematological and non-hematological diseases, i.e., cardiovascular and cerebrovascular diseases.The activity of the platelet effected is reflected in PVI i.e. platelet counts, MPV (mean platelet volume) and P-LCR (platelet large cell ratio) in these conditions, hence PVI provide a simple and easy method of indirect assessment of platelet function routinely generated by automated cell counters, both represents changes in their level of stimulation or rate of destruction. It isstill not clearly fully resolved yet.Several studies showed highly variable references due to heritable, [1] genetic,gender,altitudefactors both in healthy and diseasedindividuals [2-3] .Similarly, ethnicity-related differences had been reported in Western studies i.e.USA, Italy [3] and various African countries [4] , in addition other risk factors like hypertension, Diabetes mellitus, renal failure, atrial fibrillation, elderly people, obese, and smokers had also been associated. Aims;-Asthe methodology has changed from manual to the modern automated analyzer, this study was conducted to document the significance of platelet large cell ratio (P-LCR), MPV (mean platelet volume) and their relation to total platelet count as very less literature is available on the subject. Method and Material;-A study todetermine the reference range of PLCR, MPV (mean platelet volume) was conduct in government medical college and associated tertiary care Hospital. The studywas conducted on randomized 2084subjectsof original Kashmiri population aged 10-75yrs.Theblood collected was processed inan automated analyzer. Conclusion;-Platelet counts variation does not reveal the underlying cause, as physiological, demographic,genetic,ethical, and pathological factors,with the emergence of new factors that had surfaced recently their correlation will preventinhabitants in different areas, who are at risk of receiving wrong diagnosisand treatment.
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Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018
Penyakit Diabetes Melitus (DM) merupakan kelainan yang tersebar luas di seluruh dunia. Penyakit DM tipe 2 dengan komplikasi lama berkaitan dengan gangguan pembuluh darah yang timbul mencakup yang terkait mikrovaskuler seperti: retinopati, nefropati dan neuropati, serta komplikasi makrovaskuler seperti: penyakit jantung koroner dan penyakit pembuluh darah besar. Trombosit yang berukuran besar bersifat trombogenik dan menjadi faktor kebahayaan komplikasi mikro dan makrovaskuler. Penelitian ini untuk mengetahui nilai Mean Platelet Volume (MPV) di pasien DM tipe 2 dengan komplikasi makro dan mikrovaskuler dan tanpa komplikasi vaskuler; serta pembanding sehat dari yang tidak berpenyakit diabetik dengan cara membandingkan. Penelitian ini bersifat potong lintang dengan menggunakan data rekam medis pasien di rumah sakit Dr.Wahidin Sudirohusodo Makassar selama masa waktu antara bulan Januari 2011−Desember 2013 terhadap 314 pasien DM tipe 2 (136 dengan komplikasi makrovaskuler dan 49 komplika...
Deteksi Dini Kanker Serviks Dengan Iva Test DI Lapas Perempuan Klas Iib Yogyakarta
Jurnal Kebidanan Indonesia
terdiri dari 50 warga binaan menggunakan teknik pengambilan sampel purposive samplingdengan kriteria usia subur (20-45 tahun), sudah pernah berhubungan seksual, tidak sedang menstruasi. Kegiatan dibagi menjadi 2 sesi yaitu sesi pertama penyuluhan tentang IVA Test dan sesi kedua pemeriksaan IVA Test.. Hasil: Karakteristik responden sebagian besar kasus hukum yang dialami adalah narkotika (58%) dan lama hukuman ≤ 10 tahun (80%). Variable perilaku seksual untuk umur pertama berhubungan seksual sebagian besar >20 tahun (60%) dan pasangan seksual 1 orang (68%).Variable pencucian vagina (vaginal douching) sebagian besar melakukan pencucian vagina (98%) dan media pencucian vagina menggunakan sabun mandi (32%).Riwayat obstetric sebagian besar pernah melahirkan 2-4 kali (44%).Riwayat kanker dalam keluarga sebagian besar tidak mempunyai riwayat 84%). Hasil pemeriksaan Iva test sebagian besar negative (98%). Hasil inspeksi serviks sebagian besar erosi portio (42%). Kesimpulan:Hasil deteksi dini kanker serviks dengan IVA Test di Lapas Perempuan Klas IIB Yogyakarta 80% negatif.