Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report (original) (raw)

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterized by intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanin deposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to the general population. Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Several months ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinal complaints such as nausea or vomiting were previously denied. Dermatological examination in the oris et ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathological examination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patient had an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, no abnormalities were found and no signs of malignancy were found on histopathological examination. Conclusion: Result of histopathological examination showed an increase in the number of melanocytes in the stratum basale with lined melanocytes. Based on histopathological examination in this patient more leads to the diagnosis of PJS