Aggressive (deep) angiomyxoma of the vulva: a case report (original) (raw)

Aggressive angiomyxoma of the vulva - a rare entity: case report and review of literature

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Aggressive angiomyxoma (AA) is an extremely rare locally invasive mesenchymal tumor with a high risk of recurrence. Till date, only about 350 cases reported worldwide. Because of the rarity it should be considered as differential diagnosis whenever patient present with vulvovaginal growth. The diagnosis is clinched on histopathology. These are hormone-dependent and have estrogen and progesterone receptors. Hence sometimes GnRH agonists are used for ovarian estrogen secretion suppression but long-term use is not advocated due to side effects. A 45-year-old P4 L4 perimenopausal female presented to the GOPD with a 4×4×3 cms pedunculated painless globular mass on right labia majora. On palpation, the globular mass was firm, non-tender and with a smooth surface. Mass was excised and on gross histopathology, cut sections showed white myxoid areas. On microscopy epidermal lined tissue with stellate and spindle-shaped mesenchymal cells was found, embedded in a loose myxoid stroma with few c...

Aggressive angiomyxoma of the vulva: a case report and review of literature

Archives of Gynecology and Obstetrics, 2008

Background Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasize. Case report We describe a case of AA in the left labium majus pudendi in a 47-year-old woman who underwent incomplete surgical excision. Follow-up 2 years later revealed no recurrence. Conclusion In the past, most authors advocated wide excision even if genitourinary and digestive tract resection were necessary. These days, a less radical surgery is recommended, but the signiWcance of hormonal treatment and/or radiation therapy is not clear yet. Further investigation is necessary.

Aggressive Angiomyxoa of Vulva: Wide local excision case report

Aims and Background: Aggressive angiomyxoma is rare tumor of pelvic and perineal organs, occurring usually in women of reproductive age, and carrying a high tendency to local infiltration and relapse. It is non-malignant but can be locally aggressive and frequently recurs. Misdiagnosis is frequent. Wide excision is the preferred method of treatment but the challenge is to perform the degree of extirpation necessary to prevent recurrence. Most literature about Aggressive angiomyxoma consists of isolated case reports. Presentation of Case: We reported a case of 35-year-old Indian woman complaining of a slow and progressive growth of a left vulvar labia major a pedunculated tumor with long a stalk was detected second time after first resection 2yrs back, measuring of 15.0x8.0 cm. Wide local surgical resection of the tumor were performed. Histopathology diagnosed a large aggressive angiomyxoma with uninvolved resection margins. Patient remains without recurrence at 8.0-months follow up. Discussion and Conclusion: Non Aggressive angiomyxomais rare but should be excluded in any large vulval mass. We expect that awareness accompanied with wide free safe margin excision has important role to prevent the recurrence of tumor.

Aggressive angiomyxoma of vulva: a rare and interesting entity

International Surgery Journal

We report a case of a 44-year-old female with aggressive angiomyxoma arising from right labia majora. The patient presented with a gradually enlarging vulvar mass and was treatment included wide local excision of the mass with R0 resection. Pre operative and final histopathology was consistent with features of aggressive angiomyxoma. Angiomyxoma is a rare, benign, locally infiltrative mesenchymal tumor that occurs in females at reproductive age. Repeated recurrence and locally invasive characteristics of the tumor makes it important to be considered as a part of the differential diagnosis especially in cases of pelvic mass in females.

A case of aggressive angiomyxoma of the vulva

日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology, 2007

Aggressive angiomyxoma (AA) is a rare mesenchymal neoplasm of the female pelvis and vulva, which has a tendency for local recurrence. AA is occasionally misdiagnosed as Bartholin's gland cyst or abscess, lipoma, simple labial cyst, or soft tissue tumors. We describe a case of AA on the outside of the left labium majus pudendi in a 28-year-old female. We were able to make the preoperative diagnosis of AA by magnetic resonance imaging (MRI) and ultrasound (US), and to perform complete surgical excision with a transperineal minimally invasive approach. The novelty of this case is the use of ultrasound for the diagnostic workup of the perineal tumor and determination of the incision line.

Aggressive Angiomyxoma of Vulva

Birat Journal of Health Sciences, 2021

Aggressive angiomyxoma is a rare, slowly growing, and benign tumor of mesenchymal origin that usually occurs in the pelvis and perineum of young females. Steeper and Rosai in 1983, first described angiomyxoma. The term “aggressive” underlines the tumour’s locally infiltrative nature and high risk for local recurrence. The rate of relapse varies from 35% to 72%, however, it rarely metastasizes so it has an overall good prognosis. Diagnosis is mainly made on histopathology after surgical resection. The optimal treatment for aggressive angiomyxoma is wide local excision with tumor free margin. We here report a case of aggressive angiomyxoma in 22 years female who presented with mass on left labia majora.

Aggressive angiomyxoma of the vulva - a case report

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1998

Aggressive angiomyxoma (AAM) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency for local recurrence, but usually does not metastasize. We describe a case of (AAM) in the left labium majus in a 35 year-old woman.

Vulval angiomyxoma: a case report

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Aggressive angiomyxoma is a rare, locally invasive mesenchymal tumor occurring usually in women of reproductive age, which carries a high risk for local relapse; hence it needs to be differentiated from other mesenchymal tumors occurring in this region. We describe a case of a 39-year-old female presenting with a large swelling on the left labia majora. Initially she presented as a small mass over left labia majora 2 years ago from which biopsy was taken which came as acute inflammatory (suppurative) lesion on histopathological report.Now she presented with a mass of 14×10 cm over left labia majora, left perineal region, protruding into the left vaginal wall as well. Clinical examination revealed mass over vulvo-perineal region with variegated appearance and soft to firm in consistency. On per vaginum examination, the mass was extending upto the level of ischiorectal fossa. FNAC of the mass was done and the cytological report came out to be fibrolipoma. In view of benign nature of h...

Giant Deep Aggressive Angiomyxoma of The Vulva: A Rare Case Report

Bali Medical Journal

Background: Deep Aggressive Angiomyxoma (DAA) is a rare benign tumor with about 250 cases reported worldwide. It was first reported in 1983. This tumor is commonly found in women of reproductive age, with the highest incidence in the 3rd and 4th decades of life. DAA is most often found in the pelvic, genital, inguinal region, or perineum. Case Report: Nulligravida woman 52 years old, with enlargement of the vulva that had felt since ± 20 years ago. A mass was found on local examination of the right vulva with a size of ±50x40x10cm, which was supple, mobile, and with no pain. Enlarged inguinal lymphadenopathy was also observed. MRI showed a well-defined lesion at the right vulvar region (which visualized the size of ± AP 14.95 x LL 31.80 x CC 15. 3 cm) with the signal intensity hypointense on T1WI, hyperintense on T2WI and FatSat, restricted on DWI, with no enhancement was seen. A wide excision was conducted, and post-excision measurements showed a right vulvar mass size was 50x42x10...

Aggressive Angiomyxoma of the Vulva: A Bizarre Perineal Lesion

Case reports in oncological medicine, 2015

Introduction. Aggressive angiomyxoma is a rare, slowly growing, and benign tumour of mesenchymal origin, which affects women of reproductive age and is associated with a high risk of local recurrence. Case Presentation. A case of a 47-year-old white female is presented herein, with a large polypoid, gelatinous mass on the right labia majora, measuring 26 × 21 × 6 cm. Histopathologically, the lesion was composed of spindle and stellate-shaped cells embedded in a myxoid matrix. Another specific feature was the presence of variable-sized thin-walled capillaries and thick-walled vascular channels. The patient underwent wide local excision of the tumour with clear margins and developed local recurrence 18 months later. Discussion. Aggressive angiomyxoma of the vulva needs to be distinguished from benign myxoid tumors with a low risk of local recurrence as well as from malignant myxoid neoplasms. Usually wide local excision with tumour-free margins and occasionally hormonal manipulation is the treatment of choice.