One pot three-component synthesis of imidazole derivatives using NH3/NH4Cl (original) (raw)
Related papers
Synthesis and Characterization of Imidazole Derivatives and Catalysis Using Chemical Pharmaceutical Compounds, 2019
This review is an updated and expanded version of imidazole represent an important class of heterocycles, which contains two hetero (nitrogen) atoms and two double bonds. There are so many compounds which contain Imidazole ring and exhibit different types of pharmacological and biological activities such as antimicrobial, antitumor, antiepileptic, and antihistaminic, anti oxidative, anti-inflammatory, anti diarrhoeal, analgesic, which has caused an excessive use of drugs.
A Review on Heterocyclic: Synthesis and Their Application in Medicinal Chemistry of Imidazole Moiety
Science journal of chemistry, 2018
In an organic chemistry, largest families of organic compounds are belongs in the heterocyclic compounds. In our daily life important of heterocyclic compounds are of very essential. It has broad range of application in medicinal chemistry and in agrochemicals products. Applications are also found in as developers, as corrosion inhibitors, sanitizers, as copolymers, antioxidants, dye stuff. There is always an important thing about an efficient methodology for synthesizing of new heterocycles moiety. Now in literature survey reveals that more than 85-95% new drugs containing heterocycles which has bright scientific insight in the biological system. In this review work, I mainly focus such type of heterocycle and their families which has main utility in medicinal chemistry. In the recent past developments of imidazole-based compounds in the wide range of medicinal chemistry such as antihypertensive, antineuropathic, antitubercular, antiviral, anti-inflammatory, antibacterial, antiobesity, antiparasitic, antifungal, antihistaminic, anticancer, and other potential medicinal agents with their broad applications in pathology and diagnostics. Derivatives of imidazole have placed a unique position in the medicinal chemistry field. The involvement of the imidazole scaffold is a key of synthetic strategy in the drug discovery system. The imidazole moiety is a part of several important naturally occurring products, including histamine, purine, nucleic acid and histidine. It is expected that this brief review could be attractive for new thoughts from academia and pharmaceutical industries to designs of more biologically active and non-toxic imidazole-based drugs. The aims of this review work to the reported imidazole derivatives with pharmaceuticals activity during the past years.
PROSPECTS FOR THE CHEMISTRY OF IMIDAZOLE DERIVATIVES (Review)
Chemical Journal of Kazakhstan
The problem of creating new effective domestic pharmacological preparations, including the development of the methods for obtaining biologically active substances in compliance with the “green chemistry” principles, are among the priority areas for the development of chemical science. The choice of an initial molecule, which carries the potential of biological activity, is the guarantor of a successful experimental search. Imidazole derivatives occupy a unique place in the medicinal chemistry. An imidazole cycle is part of the natural compounds such as histamine, biotin, some alkaloids and nucleic acids, and is a structural fragment of medicinal preparations. The goalof the present review is to analyze the publications on the chemistry of imidazole derivatives with an emphasis on the methods of obtaining biologically active and other practically useful molecules with an obligatory imidazole cycle. The objects of the study:imidazole derivatives. The examples of the routes of synthesi...
Zeitschrift für Naturforschung B, 2015
Ten 1,2,4,5-tetra-substituted imidazole derivatives have been synthesized with a 2-hydroxyethy substituent at the 1-nitrogen atom and potentially electron releasing hydroxy-, methoxy-, dimethylamino- or nitro substituents in various positions on the benzene ring located on the 2-carbon atom. The prototypical derivative with an unsubstituted phenyl ring at the 2-position is also reported. The compounds are obtained in excellent yields (average 86%) via a four-component cyclocondensation reaction of benzil, ethanolamine, and the appropriate aromatic carbaldehyde together with ammonium acetate. The reaction uses a novel ionic liquid catalyst, DEAHS (diethyl ammonium hydrogen sulfate), under solvent-free conditions and a green synthetic protocol. The key advantages of this process are high yield, shorter reaction times and ease of work-up. Furthermore, the products can be purified by a non-chromatographic method and the catalyst is re-usable. All of these newly synthesized compounds hav...
Synthesis and study of biological activity of some new Imidazole derivatives
In this work ester derivatives were synthesized by the reaction of imidazole derivatives (C1) with ethylchloroacetate in ethanol and NaOH to give the corresponding (C2) .While compound (C3) acetohydrazide was synthesized by the reaction of ester derivatives (C2) with hydrazine hydrat in ethanol. Compound (C3) from the reaction with different aromatic aldehydes in absolute ethanol gave the Schiff′s bases (C4,C5). The product compounds were characterized by FT-IR, U.V and 1 HNMR spectra and the biological activities were studied as antibacterial.
Synthesis and Biological Evaluation of Novel Imidazole Based Compounds
Universal Journal of Pharmaceutical Research, 2017
Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.
Routes of synthesis and biological significances of Imidazole derivatives: Review
Imidazole is a five membered, heterocyclic ring containing two hetero (nitrogen) atoms and two double bonds. Many imidazoles molecules are synthesized either through fusion or substituting various functional groups in the lead moiety. Several methods of synthesis were reported till date. Imidazole has already been reported to possess many biological activities like anticancer, analgesic, anti-inflamatory, antiviral, antihelmintic, anticonvulsant, aniallergic, antiulcer etc. the article here focus on various synthetic procedures and biological properties chemistry and major reactions of various imidazole derivatives in a comprehensive manner. Keywords: imidazole, anticancer, analgesic, antiinflamatory, antiviral, antihelmintic, anticonvulsant, aniallergic, antiulcer
Synthesis and antimicrobial study of 2-amino-imidazole derivatives
2018
A novel series of 2-amino-imidazole derivatives have been synthesized by conventional method from various di carbonyl compounds with substituted N-phenyl amides in presence of ammonium acetate and glacial acetic acid under reflux conditions with good yields. All the synthesized compounds have been characterized by IR, 1H and 13C NMR, mass and elemental analysis in full accordance with their depicted structures. The synthesized products have been screened for antimicrobial activity and the results reveal that introduction of amine at 2nd position of imidazole moiety enhances the antibacterial as well as antifungal activity.
Synthesis of Novel Imidazole Compounds and Evaluation of Their Antimicrobial Activity
Indo Global Journal of Pharmaceutical Sciences
Imidazoles are an important class of heterocycles and include many substances of both biological and chemical interest. Insertion of the imidazole nucleus is an important synthetic strategy in drug discovery. Imidazole drugs have broad applications in many areas of clinical medicine. These are currently used as tools in pharmacological studies. The important therapeutic properties of imidazole related drugs have encouraged the medicinal chemists to synthesize and test a large number of novel molecules. In this investigation, it was of interest to synthesize imidazole by refluxing 9, 10-phenenthraquinone with aryl aldehyde, primary amines and ammonium acetate in the presence of glacial acetic acid and a novel series of imidazole derivatives. The structures of the compounds have been established on the basis of spectral analytical data. All the derivatives have been screened for their antimicrobial activities at the 100µg/ml and 200µg/ml against Candida albicans. © 2011 IGJPS. All rig...