The Relationship between hnRNA and mRNA (original) (raw)

mRNA: The Relation of Structure to Function, 1977

Abstract

Publisher Summary This chapter discusses that several types of structural and kinetic evidence indicate that hnRNA contains mRNA precursors in a variety of forms. In some cases the precursors consist of hnRNA niolecules that are considerably larger than the mature mRNA. In other cases the size of the pre-mRNA is similar to that of the mature mRNA, either because processing events have closely followed transcription, or because the transcriptional units are not significantly larger than the mature mRNA. The mRNA segments may be located at the 5' termini of initial transcripts as well as at internal regions that are exposed by appropriate processing cleavages. Nuclear processing of the mRNA precursors is completed by cap formation on the 5' terminus and, for most mRNA species, methylation of internal adenylate residues and polyadenylylation of the 3'-OH terminus. The cellular content of any particular mRNA species and its precursors is determined by the relative rates of transcription, processing and turnover.

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