CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3 (original) (raw)
Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human
Nam hoàng
Nature Genetics, 2000
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Nuclear Localization of Ataxin-3 Is Required for the Manifestation of Symptoms in SCA3: In Vivo Evidence
Franco Laccone
Journal of Neuroscience, 2007
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Nuclear Localization of the Spinocerebellar Ataxia Type 7 Protein, Ataxin-7
Pamela Skinner
Human Molecular Genetics, 1999
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Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery
Zsuzsanna Izsvák
Redox Biology, 2020
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Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
Bruno Almeida
The Journal of cell biology, 2016
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Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
Sarita Lagalwar
Journal of Experimental Neuroscience, 2016
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Cellular Turnover of the Polyglutamine Disease Protein Ataxin-3 Is Regulated by Its Catalytic Activity
Mário Laço
Journal of Biological Chemistry, 2007
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Ataxin-3 Is Translocated into the Nucleus for the Formation of Intranuclear Inclusions in Normal and Machado–Joseph Disease Brains
Hidehiro Mizusawa
Experimental Neurology, 2000
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High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells
Peter Groscurth
Human Molecular Genetics, 1999
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Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon
I. Zalachoras
Neurobiology of Disease, 2013
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The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Anabela Silva-fernandes, Patricia Maciel
PLoS genetics, 2015
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Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia Type 3 disease protein
Henry Paulson
2019
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An Isoform of Ataxin-3 Accumulates in the Nucleus of Neuronal Cells in Affected Brain Regions of SCA3 Patients
Franco Laccone
Brain Pathology, 2006
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Nucleocytoplasmic Shuttling Activity of Ataxin-3
Patricia Maciel
PLoS ONE, 2009
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Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model
Sarita Lagalwar
Neurobiology of Disease, 2018
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Regulation of Ataxin-1 Phosphorylation and Its Impact on Biology
Sarita Lagalwar
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A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript
richard mceachin
Human molecular genetics, 2014
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Partial Loss of Ataxin-1 Function Contributes to Transcriptional Dysregulation in Spinocerebellar Ataxia Type 1 Pathogenesis
Juan Crespo-Barreto
PLoS Genetics, 2010
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Axonal inclusions in spinocerebellar ataxia type 3
Henry Paulson
Acta Neuropathologica, 2010
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Identification and functional dissection of localization signals within ataxin-3
Paul Antony
Neurobiology of Disease, 2009
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Identification of a novel phosphorylation site in ataxin-1
Cynthia Vierra-green
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
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Factors associated with ATXN2 CAG/CAA repeat intergenerational instability in Spinocerebellar ataxia type 2
Luis Almaguer-Mederos
Clinical Genetics, 2018
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Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology
Hong-Yu Hu
Scientific reports, 2014
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The Molecular Basis of Spinocerebellar Ataxia Type 7
Amit Ahluwalia
Frontiers in Neuroscience, 2022
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Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death
Dung Nguyen
Human Molecular Genetics, 2003
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Molecular pathogenesis of spinocerebellar ataxias
Paola Giunti
Brain, 2006
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