Effect of Tetragonia tetragonoides (Pall.) Kuntze Extract on Andropause Symptoms (original) (raw)
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Antioxidant effect of Spinach on Intra-testicular Testosterone levels in Obese Rats
2019
levels and histopathological changes in testicular tissue in obese Sprague Dawley rats. The research was performed in the multidisciplinary research laboratory of Islamic International Medical College, Rawalpindi in association with the high fat diet to induce obesity. After inducing obesity, Experimental group was divided into Group B-Obesity control group and Group C-Spinach treated group. Intra-testicular testosterone levels and testicular tissue histology of Group A and Group B rats were evaluated. Afterward 5% spinach hot water extract along with high fat diet was given to Group C for four weeks and finally Intra-testicular testosterone levels and testicular tissue histology were measured in this group. In this study, 40 male Sprague Dawley rats were randomly It was an experimental, randomized control trail.
The Aging Male, 2016
This study examined the effect of Testofen, a specialised Trigonella foenum-graecum seed extract on the symptoms of possible androgen deficiency, sexual function and serum androgen concentrations in healthy aging males. This was a double-blind, randomised, placebocontrolled trial involving 120 healthy men aged between 43 and 70 years of age. The active treatment was standardised Trigonella foenum-graecum seed extract at a dose of 600 mg/day for 12 weeks. The primary outcome measure was the change in the Aging Male Symptom questionnaire (AMS), a measure of possible androgen deficiency symptoms; secondary outcome measures were sexual function and serum testosterone. There was a significant decrease in AMS score over time and between the active and placebo groups. Sexual function improved, including number of morning erections and frequency of sexual activity. Both total serum testosterone and free testosterone increased compared to placebo after 12 weeks of active treatment. Trigonella foenum-graecum seed extract is a safe and effective treatment for reducing symptoms of possible androgen deficiency, improves sexual function and increases serum testosterone in healthy middle-aged and older men.
2018
Introduction: Aging can cause decreased testosterone levels in men which is known as andropause. Some herbs are known to increase the levels Testosterone. One of them is Klabet seed that contain phyto-testosterone. The purpose of this study was to prove that the administration of ethanol extract of Klabet seeds increased testosterone levels in old male Wistar rats. Methods: A pretest-posttest control group design study was conducted using 20 male white wistar rats that were divided into 2 (two) groups: control group that received 2 cc of distilled water and treatment group that received 2 cc ethanol extract of Klabet seeds 250mg/250gBB rats/day by sonde for 14 days. The testosterone level was measured on day 1 and 15. Results: The analysis showed that there was no significant difference in the pre-test and post-test testosterone level P0 (Pre-test:16.4±0.553 ng/ml; posttest: 15.9±1.51ng/ml) while increased level of testosterone could be observed in treatment group (P1) (pre-test: 16.6±0.476ng/ml; post-test: 19.4±0.828ng/ml. Comparative analysis between post-test results (P0 vs P1) showed that the difference was statistically significant (p <0.001). Conclusion: Oral administration of Klabet seeds ethanol extract can significantly increase testosterone level in old male wistar mice.
This study was conducted on 30 consecutive male patients presenting to Kasr-Al Ainy Andrology outpatient clinic complaining of manifestations of partial androgen deficiency in aging males (PADAM). In this study (750 mg/day) of Tribulus terrestris in 3 divided doses, each of 250 mg, as an endogenous testosterone enhancer had been tried for a duration of 3 months and the evaluation of its effect had been monitored for each patient concerning its effect on serum testosterone (total and free) and luteinizing hormone (LH), as well as its impact on erectile function, which was evaluated by the International Index of Erectile Function-5 (IIEF-5) questionnaire for those patients. Results showed a statistically significant difference in the level of testosterone (total and free) and IIEF-5, but no statistically significant difference in the level of LH before and after treatment. Also, the study showed statistically significant correlation between testosterone (total and free) and IIEF-5, but no statistically significant correlation between the level of LH and the IIEF-5 before and after treatment.
Biological Evaluation of Anti-androgenic Effect of Some Plant Foods
Journal of Food and Nutrition Research, 2014
The present study was carried out to evaluate the anti-androgenic effect of flax (Linum usitatissimum L.), sesame (Sesamum indicum), safflower seed (Carthamus tinctorius) and soybean (Glycine max L.) seeds in form of petroleum ether, ethanol extracts [(300 mg.kg -1 rat body weight)] and whole powder (20% in the diet) using prostate weight method in castrated rats. The safety of the studied plants' was evaluated through determination of liver and kidney functions. Chemical compositions of the studied plants clarified that the highest content of fat (52.5%) and ash (7.5%) were present in sesame seeds, while safflower seeds showed the highest content of crude fiber (11.8%) and carbohydrate (37.8%) also soybean contains high percentage of protein (41.2%). Sesame seeds showed the highest content of total phenolic compound (196.55 mg GAE/100 g), while soybean showed the lowest content (132.5 mg GAE/100 g). Fatty acids analysis revealed that oleic acid was present only in sesame seed oil (66.74%). Linolenic acid (ω-3) (55.77%) was the major fatty acid in flaxseed oil. Soybean oil showed the highest content of linoleic acid (ω-6) (69.84%). All studied plants' oil contains stigmasterol and β-sitosterol. Safflower seed oil showed the highest content of campesterol (9.02%). Administration of different studied plants' to castrated rats produced reduction in prostate weight and significant reduction in testosterone level with variable degrees. All studied plants' showed complete safety towards liver and kidney function. In conclusion, all studied plants could be used as new potential therapeutic candidate for the treatment of androgen-related diseases. . androgenic effect of petroleum ether and ethanol extracts of flaxseed, sesame seeds, safflower seeds and soybean seeds. Also the anti-androgenic effect of the powder form of the studied plants' was evaluated. Fatty acids, phytosterols and total phenolic contents of the studied plants were also assessed.
Journal of Fatima Jinnah Medical University
Background: Obesity is a prevailing metabolic disorder that affects the functioning of the male reproductive system. Excessive adipose tissue enhances reactive oxygen species generation and is linked with male infertility. Spinach has demonstrated antioxidant effects. The present study was conducted to determine the antioxidant effects of spinach on sperm parameters in obese Sprague Dawley rats. Subjects and methods: This randomized control study was conducted at the animal house of the National Institute of Health Islamabad, Islamic International Medical College, Cosmesurge International Hospital, Rawalpindi, and Apollo lab, Islamabad, Pakistan from April 2016 to March 2017. Forty male Sprague Dawley rats having an age of 8 weeks and weight 160-200g were tagged from number 1 to 40. Every third rat was randomly allocated to control Group A (n=13) and remaining into the Experimental group (n=27). Rats of control Group A was given a standard diet while a high-fat diet was given to Exp...
Phytotherapy Research, 2015
The aim of the study was to evaluate the effect of Trigonella foenum-graecum (fenugreek) seed extract on sex hormones and sexual function in healthy menstruating women who reported low sexual drive. This short term, single site, double blind, randomised, placebo-controlled study was conducted on 80 women, aged 20 to 49 years. Participants were randomised to either an oral dose of a standardised T. foenum-graecum seed extract (libifem) at a dose of 600 mg/day or placebo over two menstrual cycles. Dehydroepiandrosterone sulfate, progesterone, androstenedione, total and free testosterone, estradiol (E2), luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin and cholesterol were measured at baseline and 8 weeks. The individual aspects of sexual function were measured using the Derogatis interview for sexual functioning and female sexual function index self-administered questionnaires. Stress, fatigue and quality of the relationship with partner were also measured using the PSS (Perceived Stress Scale), MFI-20 (Multidimensional Fatigue Inventory) and DAS (Dyadic Adjustment Scale) quality of life measures, respectively. There was a significant increase in free testosterone and E2 in the active group as well as sexual desire and arousal compared with the placebo group. The results indicate that this extract of T. foenum-graecum m a yb ea useful treatment for increasing sexual arousal and desire in women.
European Journal of Medical and Health Sciences, 2021
Purpose: Over time, plants have been a major source of medicine to treat and cure various ailments and diseases. In many cases, the dosages and standardization of these herbal products have been so ignored that it results in these products causing damages to certain organs of the body unnoticed. The impact of ethanolic leaf extract of Nauclea latifolia on the testes was determined using Wistar rats. Method: 500, 1000 and 1500 mg of ethanolic leaf extract of Nauclea latifolia /kg body weight was administered for 21 days to 4 groups of animals (n=10). Blood sample was taken for hormonal assay, testicular weight measured, and histological procedure done, and the tissues stained with PAS. Results: Result from hormonal assay showed reduced level of testosterone and follicle stimulating hormone. After histological staining using periodic acid Schiff method (PAS) and subsequent examination using a compound microscope, there was a reduced level of glycogen granules in all the Nauclea latifo...
2021
Introduction. Several causes among which the deficit of androgens are at the origin of the erectile dysfunction. In the West region of Cameroon, more particularly in the locality of Dschang, traditional healers use the bark of Spathodea campanulata P. Beauv. (S.campanulata), belonging to the family Bignoniaceae, for the treatment of erectile dysfunction. The purpose of this study was to evaluate the androgenic properties of the aqueous extract of S. campanulata trunk bark on the androgenic parameters of adult male rats. Methods. To do this, 25 male rats were used and divided into 5 groups that were treated: group I received the reference substance (testosterone enanthate) at 5 mg / kg weekly and constituted the positive control. Group II was the negative control and received distilled water at a dose of 5 ml / kg daily. The others were the experimental groups and received extract at doses of 200 mg / kg (group III) and 400 mg / kg (group IV) and 800 mg / kg (group V) daily. Administ...