Lipid-Lowering and Antioxidant Functions of Bottle Gourd (Lagenaria siceraria) Extract in Human Dyslipidemia (original) (raw)
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Journal of Herbal Medicine, 2013
Antihyperglycemic a b s t r a c t Patients with diabetes mellitus have a higher risk of cardiovascular disease. Therefore, a reduction in all cardiovascular risks such as dyslipidemia, hypertension and being over-weight is advisable. Plants or their extracts such as Lagenaria siceraria (Bottle gourd) may have a potential therapeutic role in the treatment of diabetes. The aim of this study was to evaluate the neutraceutical potential of bottle gourd juice in the management of human diabetes and associated dyslipidemia. The study involved the administration of freshly prepared bottle gourd juice (200 ml) to 100 human participants (diabetic patients n = 50; healthy volunteers n = 50) on an empty stomach for 90 consecutive days. Biochemical markers of carbohydrate and lipid metabolism plus kidney and liver functions were monitored at monthly intervals during the course of bottle gourd juice administration.
Journal of …, 2009
Ethnopharmacological relevance: Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. Aim of the study: The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in experimentally induced hyperlipidemia in rats. Materials and methods: Methanolic extract of Lagenaria siceraria fruits (LSFE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10 mg/kg; p.o.) was used as a standard drug. Results: At the 30th day, most significant reduction in lipid levels in the LSFE treated rats as compared to the rats fed with high-fat diet at the 0th day were: total cholesterol 290.14 ± 18.42 mg/dl vs. 228.58 ± 16.38 mg/dl, low-density lipoprotein cholesterol 195.14 ± 8.86 mg/dl vs. 120.57 ± 8.11 mg/dl, triglyceride 232.41 ± 15.22 mg/dl vs. 181.79 ± 15.68 mg/dl, very low-density lipoprotein cholesterol 46.48 ± 3.04 mg/dl vs. 36.35 ± 3.13 mg/dl (P < 0.0001). Conversely, high-density lipoprotein cholesterol levels were significantly (P < 0.0001) increased from 48.52 ± 6.52 to 71.66 ± 5.14 mg/dl. The increase in weight in rats administered with LSFE was less when compared to rats fed with high-fat diet. Moreover, LSFE also exhibited significant increase in excretion of bile acids. Conclusion: The results demonstrate that the LSFE has a definite antihyperlipidemic potential. There is also a valid scientific basis for consuming it in the treatment of coronary artery diseases in India.
Journal of Ethnopharmacology, 2009
Ethnopharmacological relevance: Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. Aim of the study: The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in experimentally induced hyperlipidemia in rats. Materials and methods: Methanolic extract of Lagenaria siceraria fruits (LSFE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10 mg/kg; p.o.) was used as a standard drug. Results: At the 30th day, most significant reduction in lipid levels in the LSFE treated rats as compared to the rats fed with high-fat diet at the 0th day were: total cholesterol 290.14 ± 18.42 mg/dl vs. 228.58 ± 16.38 mg/dl, low-density lipoprotein cholesterol 195.14 ± 8.86 mg/dl vs. 120.57 ± 8.11 mg/dl, triglyceride 232.41 ± 15.22 mg/dl vs. 181.79 ± 15.68 mg/dl, very low-density lipoprotein cholesterol 46.48 ± 3.04 mg/dl vs. 36.35 ± 3.13 mg/dl (P < 0.0001). Conversely, high-density lipoprotein cholesterol levels were significantly (P < 0.0001) increased from 48.52 ± 6.52 to 71.66 ± 5.14 mg/dl. The increase in weight in rats administered with LSFE was less when compared to rats fed with high-fat diet. Moreover, LSFE also exhibited significant increase in excretion of bile acids. Conclusion: The results demonstrate that the LSFE has a definite antihyperlipidemic potential. There is also a valid scientific basis for consuming it in the treatment of coronary artery diseases in India.
International Journal of Green Pharmacy, 2008
Hyperlipidemia is defi ned as increase in the lipid content (groups of fat or fat like substances along with their lipoprotein counterpart) in blood. Abundant evidence are there to proof the link between hyperlipidemia and atherosclerosis. Lagenaria siceraria commonly known as Bottle gourd, which is offi cial in Ayurvedic Pharmacopoeia of India, and having composition of variety of essential phytoconstituents, so that the fruits are traditionally used for their cardioprotective, cardiotonic, general tonic, diuretic, aphrodisiac, antidote to certain poisons and scorpion strings, alternative purgative, and cooling eff ects. In the present study fruit juice was obtained by crushing the fresh fruits of L. siceraria in the juicer and was subsequently dried in the oven at 40°-50°C. Th e parent dried juice extract was then fractionated by using the solvents according to polarity in ascending order i.e. by using chloroform: acetic acid, methanol, pyridine, and water. Each fraction was dried in oven at 40°-50°C. Th in layer chromatography (TLC) used active fraction obtained by column chromatography for further isolation. Th e solvent system developed on trial and error basis was n-butanol: methaol: water (6:2:2). Four spots were obtained and were named as LSN-I, LSN-II, LSN-III and LSN-IV. Isolated spots were collected by using preparative TLC the isolated compounds were tested for Antihyperlipidemic activity and compounds LSN-I, LSN-II, LSN-III has shown signifi cant results. Th e study exhibited that elevated levels of blood cholesterol, triglycerides, LDL, were signifi cantly reduced and decreased HDL was signifi cantly increased by the administration of fractions of L. siceraria fruit juice.
Current Nutrition & Food Science
Lagenaria siceraria, commonly known as bottle gourd, is extensively grown in India and other tropical and sub-tropical regions of the world. The bottle gourd is rich in a number of phytoconstituents, minerals, vitamins, fibre etc. with potent neutraceutical and therapeutic functions. Leaves and roots are used as emetic to reduce baldness and to relieve headache. Flowers are used as antidote in certain kinds of poisons. L. siceraria is reported to exhibit cardioprotective, antihyperlipidemic, antioxidant, antihyperglycemic, analgesic, anti-inflammatory, immunomodulatory and hepatoprotective functions in human subjects as well as in experimental models. The bottle gourd is proved to be a potential source of prophylactic and therapeutic neutraceuticals and can serve as 'medicinal food' particularly in metabolic disorders associated with carbohydrate and lipid metabolisms. The objective of this article is to review the ethnopharmacological and other medicinal applications of L. siceraria along with phytochemical and biochemical composition.
ABSTRACT The purpose of the study was to investigate the pulp waste obtained after juicing bottle gourd (LagenariaSiceraria) fruit belonging to cucurbitacae family, into a powdered product to be used into a dietary fibre supplement. It is reported that adequate dietary fibre is essential for proper functioning of the gut and has also been related to risk reduction for a number of chronic diseases including heart disease, certain cancers and diabetes. Therefore the study was undertaken to explore whether the pulp powder rich in fiber content exhibits any therapeutic properties when consumed by type II diabetic subjects. The study was begun with determination of acceptable dose of bottle gourd pulp powder (DBPP). Thereafter the pulp powder was administered to 25 diabetic subjects every day at fasted state for a month and baseline BMI, blood pressure of and fasting blood glucose (FBG) and serum lipids were recorded. Administration of pulp powder resulted in remarkable lowering of trigl...
Oxidative Medicine and Cellular Longevity
Natural antioxidants present in fruits have attracted considerable interest due to their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals of goji berry (GB) in patients with metabolic syndrome have not been investigated. In this study, we examined anthropometric and biochemical parameters in patients with metabolic syndrome after the consumption of GB. The patients were divided into two groups, control (C) and supplemented (S), and followed up for 45 days. Participants were individually instructed to carry out a healthy diet, but additionally, an inclusion of 14 g of the natural form of goji berry in the diet during 45 days for the S group was proposed. After 45 days of study, a significant reduction in transaminases as well as an improvement in lipid profile in the S group was observed. Likewise, a significant reduction in the waist circumference of the S group was observed when comp...
Toxicology international, 2012
This study investigated antihyperlipidemic effects of Lagenaria siceraria fruit juice (LSFJ) in isoproterenol (ISO)induced cardiotoxicity in rats. Rats treated with ISO (200 mg/kg, s.c.) showed a significant increase in the levels of triglycerides, cholesterol, and free fatty acids, in both serum and heart tissue. An increase in the levels of phospholipids, low-density lipoprotein, and very low-density lipoprotein-cholesterol, and decrease in high-density lipoprotein-cholesterol in serum and phospholipid levels in the heart were observed. ISO intoxicated rats also showed a significant decrease in the activities of lecithin: cholesterol acyl transferase, whereas lipoprotein lipase was found to be increased. Administration of LSFJ (400 mg/kg, p.o.) for 30 consecutive days and challenged with ISO on day 29th and 30th significantly attenuated these alterations and restored the levels of serum and heart lipids along with lipid metabolizing enzymes. Histopathological observations were als...
Fatty foods, the most common diet today are the crux of many metabolic disorders which need urgent attention. Garcinia pedunculata Roxb. (GP, Clusiaceae) is a plant found available in Northeast (NE) region of India, is considered to have versatile therapeutic properties. The people of this region has been using dried pulp of GP fruit for the treatment of different stomach related diseases traditionally. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich methanolic extract of the fruit in experimental induced obese rats. In vitro antioxidant and antidiabetic activity of GP extracts, i.e., fruit extract (GF) and seed extract (GS) were determined by using various methods viz., 1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) (ABTS • +), nitroblue tetrazolium (NBT) and α-glucosidase inhibition assay for detection of antihyperglycemic activity. In vivo antilipidemic and antiobesity activities were evaluated by administrating oral dose of GF for 60 days on a high-fat diet (HFD) induced hyperlipidemia in the rat. GF showed higher antioxidant activity than GS by DPPH radical scavenging (IC 50 = 4.01 µg/ml), ABTS • + (IC 50 = 0.82 µg/ml), NBT (IC 50 = 0.07 µg/ml) and also showed notable α-glucosidase inhibitory activity (IC 50 = 19.26 µg/ml). Furthermore, GF treated rat revealed a reduction in the body weight (∼60%), serum total cholesterol (33%), triglycerides (32%), low-density lipoprotein (38%) and liver biomarker enzymes after 60 days HFD fed animals. Simultaneously, GF supplementation significantly protected the HFD induced changes in hematological parameters. Histological observations clearly differentiate the structural changes in liver of HFD and GF treated group. This novel dietary lipid adsorbing agent of GF exhibited prevention of hyperlipidemia induced by HFD in the rat.