Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review (original) (raw)
Related papers
Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review
Al-Nahrain Journal of Science, 2021
Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.
Biological Activities of Metal Complexes of Schiff Bases -A Review
Schiff bases have ability to form complexes with transition and inner transition metals and therefore regarded as very important class of organic compounds. Schiff bases serve as special ligands because they are readily synthesized by condensation reactions of aldehyde derivatives with imines. However their production is simple, their modest manufacturing technology and wide range of applications in areas such as coordination chemistry, analytical chemistry, catalysis and medicinal chemistry make them unique compounds. Various bioactivities such as anticancer, antineoplastic, analgesic, antifungal, antiviral, antioxidant, antibacterial, antipyretic, antiproliferative and anti-inflammatory etc. of schiff bases and their metal complexes are being studied. This review highlights synthesis as well as biological applications of various schiff bases and their metal complexes.
Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities
International Journal of Molecular Sciences
Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.
Biological Importance of Schiff base Based Metal Complexes: A Brief Review
Journal of Scientific Enquiry, 2022
Schiff bases, generally synthesized by the condensation of aldehyde / ketone with primary amine, are imperative class of chelating ligands due to its coordination nature. In addition, Due to presence of imine group (-C=N), it shows various potential biological activities like antimicrobial, antifungal, antitumor, antiviral and anti-diabetic properties. Schiff base based metal complexes also exhibits potential applications in various fields such as magnetism, catalytic activity, sensing, biological activity, etc. Among the biological activity, till now Schiff base based metal complexes shows promising role as antibacterial, antifungal, antiviral, anticancer, antioxidant and anti-inflammatory agents. In this review we highlighted some Schiff base based metal complexes which attributed potential biological activity.
Application of Metal Complexes of Schiff Bases as an Antimicrobial Drug: A Review of Recent Works
International Journal of Current Pharmaceutical Research
Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scop...
Applied Sciences
Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.
A review on versatile applications of transition metal complexes incorporating Schiff bases
Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, anti-bacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Many Schiff base complexes show excellent catalytic activity in various reactions and in the presence of moisture. Over the past few years, there have been many reports on their applications in homogeneous and heterogeneous catalysis. The high thermal and moisture stabilities of many Schiff base complexes were useful attributes for their application as catalysts in reactions involving at high temperatures. The activity is usually increased by complexation therefore to understand the properties of both ligands and metal can lead to the synthesis of highly active compounds. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behaviour. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. This review compiles examples of the most promising applied Schiff bases and their complexes in different areas.
Biological Applications of Schiff base and its Metal Complexes-A Review
2014
Schiff Bases play an important role in Inorganic chemistry due to formation of very stable complexes with various transition and inner-Transition Metals. It has been extensively studied over past decades as Schiff bases provide potential sites for bio-chemically active compounds. This review is to summarize various Biological activities of Schiff Bases complexes as it has been recognized widely and Complexes may serve as biologically important species. Most of them show Biological activities such as antifungal, antibacterial, antimicrobial, and enzymatic activities.
The synthesis and characterization of a Schiff base derived from aniline and salicylaldehyde and its Co(II), Mn(II), and Zn(II) complexes is reported; several physical tools, in particular, elemental analysis, infrared and NMR techniques were used to investigate the chemical structure of the reported complexes. The ligand is found to be bound to the metal atom through the oxygen atom of the hydroxyl group, which is also supported by spectroscopic techniques. The results obtained by FT-IR and NMR showed that the Schiff base-transition metal complexes have octa hedral geometry. Biological screening of the complexes reveals that the Schiff basetransition metal complexes show significant activity against all microorganisms.