Posttransplantation relapse of pediatric chronic myelomonocytic leukemia cured using donor lymphocyte infusion (original) (raw)

This report discusses the case of an 11-year-old boy with therapy-related chronic myelomonocytic leukemia (t-CMML) who relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) but achieved long-term remission following donor lymphocyte infusion (DLI). The patient's treatment included a detailed conditioning regimen and prophylaxis for graft-versus-host disease. Following the relapse, multiple DLIs were administered, which successfully eliminated the disease markers and led to complete remission after four years. This case highlights the potential efficacy of HSCT and DLI in treating pediatric t-CMML, suggesting favorable outcomes under specific conditions.