Adenosine receptors. Part 1 : (2S,3S,4R,5R)-2-(4-(alkyl/arylamino)-5Hpyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol derivatives as possible adenosine receptor agonists (original) (raw)

Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists

Christa E. Müller

Bioorganic & Medicinal Chemistry, 2006

View PDFchevron_right

Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists

Pier Giovanni Baraldi

Bioorganic & Medicinal Chemistry, 2012

View PDFchevron_right

Pyrimidine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists

Maria Isabel Cadavid

Journal of Medicinal Chemistry, 2011

View PDFchevron_right

Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines

Colin T Dourish

Bioorganic & Medicinal Chemistry Letters, 2008

View PDFchevron_right

Synthesis of Novel Pyrido[3,2- e ][1,2,4]triazolo[1,5- c ]pyrimidine Derivatives: Potent and Selective Adenosine A 3 Receptor Antagonists

Meryem Köse

Archiv der Pharmazie, 2013

View PDFchevron_right

Structure−Activity Relationships of 2, N 6 ,5‘-Substituted Adenosine Derivatives with Potent Activity at the A 2B Adenosine Receptor

Kenneth A Jacobson

Journal of Medicinal Chemistry, 2007

View PDFchevron_right

New amino derivatives of 1,2,3-triazolo[4,5-d]pyrimidines and their affinity towards A1 and A2A adenosine receptors

Laura Betti

European Journal of Medicinal Chemistry, 1999

View PDFchevron_right

Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors

Kenneth A Jacobson

Journal of Medicinal Chemistry, 1995

View PDFchevron_right

A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists

Stephanie Federico

European journal of medicinal chemistry, 2015

View PDFchevron_right

N 6-Cycloalkyl-and N 6-Bicycloalkyl-C 5′(C 2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1 Adenosine Receptor with …

Antonio Lavecchia

Journal of medicinal …, 2009

View PDFchevron_right

Pyrazolo [4, 3-e]-1, 2, 4-triazolo [1, 5-c] pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A3 and …

Hema Latha

Journal of medicinal …, 2003

View PDFchevron_right

Novel 3-Aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5- d ]pyrimidines with High Affinity toward A 1 Adenosine Receptors

Laura Betti

Journal of Medicinal Chemistry, 1998

View PDFchevron_right

( N )-Methanocarba 2, N 6 -Disubstituted Adenine Nucleosides as Highly Potent and Selective A 3 Adenosine Receptor Agonists

Kenneth A Jacobson

Journal of Medicinal Chemistry, 2005

View PDFchevron_right

3-and 6-Substituted 2-amino-4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridines as A1 adenosine receptor allosteric modulators and antagonists

Joel Linden

Bioorganic & medicinal …, 2009

View PDFchevron_right

New Pyrrolo[2,1- f ]purine-2,4-dione and Imidazo[2,1- f ]purine-2,4-dione Derivatives as Potent and Selective Human A 3 Adenosine Receptor Antagonists

Pier Borea

Journal of Medicinal Chemistry, 2005

View PDFchevron_right

2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors

Kenneth A Jacobson

Biochemical Pharmacology, 2004

View PDFchevron_right

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes

Claudia Cusan

Purinergic Signalling, 2008

View PDFchevron_right

Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A 3 adenosine receptor antagonists

Priyankar Paira

Bioorganic & Medicinal Chemistry Letters, 2011

View PDFchevron_right

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists

Joan Alberti

Bioorganic & Medicinal Chemistry Letters, 2010

View PDFchevron_right

Adenosine Receptor Antagonists: Translating Medicinal Chemistry and Pharmacology into Clinical Utility

Mojgan Aghazadeh Tabrizi, Pier Borea

Chemical Reviews, 2008

View PDFchevron_right

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists

Gabriella Guerrini

European journal of medicinal chemistry, 2015

View PDFchevron_right

Discovery of simplified N2-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and molecular docking studies

Priyankar Paira

Bioorganic & Medicinal Chemistry, 2014

View PDFchevron_right

N 6 -Cycloalkyl- and N 6 -Bicycloalkyl- C 5′( C 2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A 1 Adenosine Receptor with Antinociceptive Effects in Mice

Riccardo Petrelli, Loredana Cappellacci, Mario Grifantini

Journal of Medicinal Chemistry, 2009

View PDFchevron_right

Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives

Laura Betti

European Journal of Medicinal Chemistry, 1998

View PDFchevron_right

Recent developments in the field of A3 adenosine receptor antagonists

Mojgan Aghazadeh Tabrizi, Pier Borea

Drug Development Research, 2003

View PDFchevron_right