Association of Thyroid Function with Metabolic Parameter in IDD Clinic Patients, Magelang Research and Development Center (original) (raw)

2021, Medico-Legal Update

Metabolic parameters, such as lipid and glucose metabolism, blood pressure, and body weight, are influenced by thyroid hormones. Thyroid dysfunction may lead to the development of the metabolic syndrome. The study aimed to analyze the relationship between thyroid dysfunction and metabolic parameters in IDD clinic patients, Magelang Research and Development Center. A cross-sectional study of 83 patients who met the inclusion and exclusion criteria. Total cholesterol, LDL, HDL, TSH, and free T4 concentration had been measured in all subjects. BMI and blood pressure were measured. Concentrations of lipids, triglycerides, free T4, and TSH were analyzed. The mean age of the patient was 33.5 ± 8.6 of whom 6 (7.2 %) subclinical hypothyroidism, 17 (20.5 %) overt hyperthyroidism, and 17 (20.5 %) had subclinical hyperthyroidism. There was positive relationship between TSH and systolic; whereas, FT4 was associated with BMI, systole, and diastole after adjustment for age. Overt hyperthyroidism had significantly higher odds of hypertension after adjustment for age and BMI (OR 5.557 (1.310-23.578), p<0.05). Hyperthyroidism may induce hypertension.